Publications by authors named "Slim Ghrir"
Article Synopsis
- Chlorpyrifos (CPF) poisoning presents a significant public health issue, and this study explores the potential protective effect of grape seed extract (GSE) against liver damage caused by CPF.
- Treatment with CPF caused major disruptions in liver metabolism, mitochondrial functions, and induced oxidative stress and cholinergic excitotoxicity in rats.
- GSE administration effectively mitigated the harmful effects of CPF by regulating certain gene expressions related to liver detoxification, suggesting that GSE could be a viable protective strategy against CPF-induced liver toxicity.
Objective: The aim of the present study was to investigate the effects of Grape seed extract (GSE) and exercise training on Doxorubicin (Doxo)-induced cardio, hepato and myo toxicities in healthy rats.
Methods: Thirty male Wistar rats were randomly divided into five groups and daily treated by intraperitoneal route during two months either with ethanol 10% (Control); Doxo (1.5 mg/kg); Doxo + exercise (1.
Myocardial infarction (MI) followed by left ventricular (LV) remodeling is the most frequent cause of heart failure. Lebetin 2 (L2), a snake venom-derived natriuretic peptide, exerts cardioprotection during acute myocardial ischemia-reperfusion (IR) ex vivo. However, its effects on delayed consequences of IR injury, including post-MI inflammation and fibrosis have not been defined.
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