Publications by authors named "Slieman Milaneh"
Article Synopsis
- Endometrial cancer (EC) is a prevalent cancer in women and is often linked to a high rate of recurrence and cancer-related deaths, making effective treatment crucial.
- Conventional therapies like surgery, chemotherapy, and radiation face challenges, particularly due to drug resistance, emphasizing the need for new therapeutic options.
- The review highlights recent advancements in small molecule targeted therapies, discussing their biological targets and potential for integrated diagnosis and treatment, along with the development of new agents that have fluorescence properties for improved clinical applications.
Eur J Med Chem
February 2024
Article Synopsis
- - SHP1 is a key player in cancer-related signaling pathways, making it a promising target for new cancer drugs.
- - Researchers created imidazo[1,2,4] triazole derivatives for SHP1 inhibition, focusing on their fluorescence properties and biological activity.
- - The compound 5p showed strong fluorescence and a significant inhibitory rate against SHP1, along with good selectivity and biocompatibility, indicating its potential for biological imaging applications.
