[Effect of Agrobacterium tumefaciens (Smith and Town). Conn. on the functional properties of human blood lymphocytes].

Agrobacterium tumefaciens has been shown to affect the proliferation of intact lymphocytes as well as lymphocytes stimulated by PHA action. Inoculation of bacteria into the cultures of intact lymphocytes and incubation during 72 h resulted in increased incorporation of [3H]-thymidine into the DNA of cultivated cells. The bacteria are capable of inhibition of lymphocytes proliferation stimulated by PHA.

[Effect of the inhibitor-antioxidant belonging to the 3-hydroxypyridine series on immunocompetent and stem cells].

The effect of the synthetic inhibitor-antioxidant belonging to the 3-hydroxypyridine series (compound OP-6) on the functions of immunocompetent and stem cells of mice was studied. Use was made of the models of synthesis of antibodies to sheep red blood cells (local hemolysis and hemagglutination), of endogeneic and exogeneic colony-formation in (CBA X C57BL)F1 mice as well as skin homotransplantation to CBA mice from C57BL/6 donors. Compound OP-6 was shown to exert an immunodepressant effect on both the humoral and cell immunity, not to decrease the colony-forming capacity of the stem cells and to protect them from irradiation.

[Effect of antioxidants with different antiradical activity on cornea preservation].

Changes of chemoluminescence intensity, collagen mucopolysaccaride content in the rabbit eye cornea were studied on 32 cornea of shinshilla eye conservated by dehydration under hipotenia (2 divided by 4 degrees C) for 60 days with the application of antioxidants (tocoferol, chlorhydrate 2-ethyl, 6-methyl-3-oxipyridine) having different antiradical activity. It is concluded that the application of natural antioxidant alpha-tocoferol having high antiradical activity is expedient for the conservation of cornea.

[Change in the antioxidizing activity of the lipids during aging].

Antioxidative activity (AOA) of lipids in mice liver was decreased in the old animals. The rate of the AOA decrease varied in different strains of mice. Alteration in the AOA is a phenomenon typical, but unspecific, for the senescence process.