Nitric oxide and tumour necrosis factor alpha in the process of pseudoexfoliation glaucoma.

Aim: To establish the role of nitric oxide (NO), ascorbic acid and tumour necrosis factor-α (TNF-α) in the pathogenesis of pseudoexfoliation glaucoma (XFG).

Methods: Our study included 120 patients who were referred for cataract surgery. All patients were divided into four groups according to clinical findings: XFG, early and late pseudoexfoliation syndrome (XFS), and cataract (without pseudoexfoliation).

Proinflammatory Cytokines Induce XFG Development.

Purpose: To reveal the roles of proinflammatory cytokines within the process of pseudoexfoliation (PEX) production.

Methods: Our study included 120 patients referred to cataract surgery (early and late stage of pseudoexfoliation syndrome (XFS), pseudoexfoliation glaucoma (XFG), and control group). Serum and humor levels of cytokines were measured in a sample with high sensitivity enzyme-linked immunosorbent assay (ELISA) kit.