Safety and Efficacy of Wireless pH Monitoring in Patients Suspected of Gastroesophageal Reflux Disease: A Systematic Review.

Introduction: The primary aim of this systematic review was to determine the safety, technical efficacy, and effectiveness of 48-hour wireless pH monitoring (WM) for gastroesophageal reflux disease (GERD), compared with no pH monitoring in patients who failed to tolerate a catheter. In the absence of eligible studies, the secondary aim was to determine these performance characteristics for WM relative to catheter-based pH monitoring (CBM) in patients suspected of GERD, who are able to tolerate a catheter.

Methods: A protocol was registered on the PROSPERO database (CRD42013005852) before conducting the systematic review, which included the study selection criteria, and critical appraisal methods.

Effectiveness of general practice-based health checks: a systematic review and meta-analysis.

Background: A recent review concluded that general health checks fail to reduce mortality in adults.

Aim: This review focuses on general practice-based health checks and their effects on both surrogate and final outcomes.

Design And Setting: Systematic search of PubMed, Embase, and the Cochrane Central Register of Controlled Trials.