Publications by authors named "Skye Balyasny"
Importance: Participants in clinical trials may experience benefits associated with new therapeutic strategies as well as tight adherence to best supportive care practices.
Objectives: To investigate whether participation in a clinical trial is associated with improved survival among children with neuroblastoma and investigate potential recruitment bias of patients in clinical trials.
Design, Setting, And Participants: This cohort study included pediatric patients with intermediate- or high-risk neuroblastoma in North American studies who were included in the International Neuroblastoma Risk Group Data Commons and who received a diagnosis between January 1, 1991, and March 1, 2020.
Article Synopsis
- - Neuroblastoma is a diverse childhood cancer that develops from neural crest cells in the sympathetic nervous system, with outcomes ranging from spontaneous regression to aggressive forms resistant to treatments.
- - Patient characteristics and tumor biology play a crucial role in prognosis, especially as low- and intermediate-risk patients often have better outcomes, while only about 50% of those with high-risk neuroblastoma achieve long-term survival.
- - Recent research has identified various genetic and chromosomal factors that contribute to neuroblastoma's development, leading to new therapies aimed at improving survival rates for affected children.