[Frequency of allele polymorphism of immune proteasome catalytic subunits in patients with ischemic stroke].

Frequency of allelic variants of proteasome subunits genes LMP2 (Arg60 --> His) and PSMA6 were determined in patients with ischemic stroke using real-time PCR. Allelic variants of PSMA6 were disposed in the next manner: C/C - 80.2%, C/G - 19.

[Expression of proteasome subunits PSMB5 and PSMB9 mRNA in hippocampal neurons in experimental diabetes mellitus: link with apoptosis and necrosis].

There is a huge body of evidence showing that long-termed diabetes mellitus is followed with hippocampal dysfunction. The goal of this work was to investigate the expression of proteasome subunits PSMB5 and PSMB9 mRNA in CA1, CA2 and CA3 areas of hippocampus in parallel with processes of cell death (apoptosis and necrosis) in development dynamics of streptozotocine-induced diabetes. We have studied hippocampal neurons using chromatine dye Hoechst-33342 and immunohistochemical detection of apoptotic cell death marker caspase-3.

[Migration and differentiation of transplanted fetal neurogenic cells in animals with brain ischemia].

The migration, integration and differentiation of fetal neural progenitor cells (NPCs) in the ischemic brain have been studied. In our study the ischemic insult in FVB line mice was produced by occlusion of both carotid arteries during 20 min. A day after occlusion NPCs from GFP-transgenic 12.

[Role of cell adhesion molecules in the modulation of synaptic activity].

Cell adhesion molecules (CAMs) can influence various developmental events, including cell migration, proliferation, and differentiation. Recent advances have provided evidence that in addition to their adhesive properties, CAMs can affect intracellular signalling and synaptic function. This review focuses on the role of CAMs in the modulation of synaptic activity.

[Neuroprotective effect of quercetin during experimental brain ischemia].

The neuroprotective action by water-soluble form of quercetin was examined in gerbils after transient forebrain ischemia. The animals were exposed to 7 min of bilateral common carotid artery occlusion. Hippocampal CA 1 area was examined 7 days after ischemia-reperfusion.