Publications by authors named "Sky Wang"
The administration of cortisone to a bedridden patient with rheumatoid arthritis (RA) 70 years ago was a transformative event in modern medicine. We have since struggled to balance the near-miraculous anti-rheumatic with the yet all-too-frequent devastating side effects of glucocorticoids (GC). With the current availability of newer disease-modifying and biologic anti-rheumatic agents, we were rather surprised to note that 94% of sick hospitalized patients with systemic rheumatic diseases at our medical center were on corticosteroids during a 3-month observation period.
View Article and Find Full Text PDFDisturbed Flow Induces Autophagy, but Impairs Autophagic Flux to Perturb Mitochondrial Homeostasis.
Antioxid Redox Signal
November 2015
Aim: Temporal and spatial variations in shear stress are intimately linked with vascular metabolic effects. Autophagy is tightly regulated in intracellular bulk degradation/recycling system for maintaining cellular homeostasis. We postulated that disturbed flow modulates autophagy with an implication in mitochondrial superoxide (mtO2(•-)) production.
View Article and Find Full Text PDFArticle Synopsis
- * In experiments with bovine aortic endothelial cells, OSS led to significant activation of JNK within an hour and increased levels of mitochondrial superoxide, but this was reduced when cells were treated with NADPH oxidase inhibitors or antioxidants.
- * Additionally, JNK inhibition methods, like siRNA transfection and specific inhibitors, also decreased the production of mitochondrial superoxide from OSS, suggesting JNK's crucial role in this oxidative process, confirmed by human artery tissue staining.