[The impact of BMI on the course of the acute SARS-COV-2 infection and the risks that emerge during the first year after the hospital discharge. Subanalysis evidence of the AKTIV and AKTIV 2 registries].

Background: There is enough evidence of the negative impact of excess weight on the formation and progression of res piratory pathology. Given the continuing SARS-CoV-2 pandemic, it is relevant to determine the relationship between body mass index (BMI) and the clinical features of the novel coronavirus infection (NCI).

Aim: To study the effect of BMI on the course of the acute SARS-COV-2 infection and the post-covid period.

[Polymorphism of genes of the renin-angiotensin system ACE, AT1R, and AT2R in patients with pulmonary tuberculosis].

The goal of this work was to verify the hypothesis about the possible role of some genes of the renin-angiotensin system in the innate immunity to tuberculosis. The insertion/deletion polymorphism (I/D) of the gene of the angiotensin-converting enzyme (ACE) is known to have an effect on the concentration of the angiotensin II in human body and also an indirect effect on various branches of metabolism. On the one hand, people with homozygote deletion of the ACE gene (DD genotype) are vulnerable to adiposity, arterial hypertension, hypercholesterolemia, and a number of other pathological conditions.

[MIRU-VNTR genotyping of Mycobacterium tuberculosis strains from East Siberian: Beijing family versus Kilimanjaro family].

Seventy-two M. tuberculosis strains isolated from patients in different regions of East Siberia were studied by MIRU-VNTR repeats. Phylogenetic trees of relationship between the studied strains and of those from other world regions were investigated by phylogenetic analysis, i.

[Prevention of reduced plasma fibronectin level in acute and chronic phenol and aniline poisoning in rats on vitamin-rich diet].

Plasma fibronectin, a glycoprotein having a great molecular weight and a quaternary structure is a specific animal protein that maintains the body's homeostasis on exposure to various adverse factors, such as mechanical, thermal or chemical injuries, infection, hemorrhage, intoxication or immune disease. In acute phenol intoxication, fibronectin levels were increased in rats up to 680 mg/l during 48 hours after the onset of priming and decreased up to 240 mg/l during the following 48 hours and then became stable. In acute aniline intoxication, fibronectin concentrations were decreased up to 120-130 mg/l during 4 days, later on its level became higher.

[The electrophoretic mobility of peripheral blood lymphocytes in patients with tuberculosis of the lungs].

The monitoring of the immune system in pulmonary tuberculosis patients and their peripheric blood lymphocyte reaction to its T-system modulators was undertaken by cellular electrophoresis. It was shown that when the lymphocyte subpopulation ratio tends to be normalized in vitro by inoculation with thymalin and T-activin, the given situation can be viewed as an indication to prescribe immunocorrection drugs to these patients. The lymphocyte subpopulation ratio check in the pulmonary tuberculosis subjects by means of the proposed method before and after the thymalin and T-activin treatment made it possible to reveal a significant normalization of the immunologic indices and to achieve better clinical condition of the patients.

[Morphofunctional evaluation of the immunogenicity of a live brucellosis vaccine].

The possibility of evaluating the immunogenic potency of brucellosis vaccine BA-19 by immunological methods has been shown. Morphometry and the quantitative evaluation of globulin-producing cells in lymphoid organs by direct and indirect immunofluorescent techniques serve as informative evaluation tests. The marker method with the evaluation of lymphocyte classes by acid and alkaline phosphatases and the electrophoretic motility characteristics of T- and B-lymphocytes, used in combination with the above-mentioned methods, present information on immunogenesis.

[Role of the vitamin factor in preventing phenol poisoning].

Experiments on rats were made to examine the effect of vitamin B1, pantothenic and ascorbic acids on the acetylation system and some characteristics of protein metabolism under chronic exposure to phenol. Inhibition of phenol vapours led to inhibition of the acetylation on the 105th day of the experiment, to accumulation of pyruvic acid by the blood and diurnal urine, to elevation of cholesterol content in the blood serum. The total content of protein and protein fractions in the blood serum remained unchanged.

[Effect of a therapeutic and prophylactic diet enriched with thiamine and calcium pantothenate on the acetylating capacity of the body of workers engaged in the manufacture of phenol-formaldehyde resins].

The present investigation uncovered certain changes in the intensity of the acetylating processes, in the blood and urine levels of the pyruvic acid and in the urinary excretion of thiamine in a number of persons engaged in the production of phenol-formaldehyde resins. An enrichment of medico-prophylactic ration No 4 with thiamine and calcium pantothenate led to normalization of the study characteristics. The results thus made available bear proof to the prophylactic effectiveness of a supplementary vitaminization of the special diet accorded to workers handling phenol-formaldehyde resins.