Transdermal Drug Delivery: Determining Permeation Parameters Using Tape Stripping and Numerical Modeling.

The function of transdermal drug delivery (TDD) systems is complex due to the multiple layers necessary for controlling the rate of drug release and the interaction with the patient's skin. In this work, we study a particular aspect of a TDD system, that is, the parameters that describe the drug permeation through the skin layers. Studies of the diffusion of two compounds were carried out and supported by tape stripping and numerical modeling.