Investigation of Strain-Promoted Azide-Alkyne Cycloadditions in Aqueous Solutions by Capillary Electrophoresis.

The Cu-free 1,3-dipolar cycloaddition of cyclooctynes and azides is an up-and-coming method in bioorganic chemistry and other disciplines. However, broad application is still hampered by major drawbacks such as poor solubility of the reactants in aqueous media and low reaction rates. It is thus of high demand to devise a fast and user-friendly strategy for the optimization of reaction conditions and reagent design.

From stereodynamics to high-throughput screening of catalysed reactions.

Characterising chemical reactions by kinetic analysis is of fundamental importance to experimentally obtain insights into reaction mechanisms. Based on such investigations reactions can be optimised and improved catalysts designed. Enhanced reaction conditions may drastically increase the performance of the reaction in terms of yield and (enantio-) selectivity.

Comparison of a molecular and an immobilized gadolinium(III)-tris[(1R,4S)-3-heptafluorobutanoyl-camphor] as catalyst in the asymmetric Danishefsky-hetero-Diels-Alder-reaction.

On-column reaction gas chromatography combines the power of separation and rapid analysis of reactants and reaction products with screening of reactions in a single step. Not only conversions but the reaction rates at various temperatures can be obtained from single measurements, making this approach superior to the time-consuming measurements typically performed in reaction progress analysis. However, this approach has only been used in the investigation of interconversion processes, rearrangement reactions, and only a few examples of higher-order reactions are known.

Integrating reaction and analysis: investigation of higher-order reactions by cryogenic trapping.

A new approach for the investigation of a higher-order reaction by on-column reaction gas chromatography is presented. The reaction and the analytical separation are combined in a single experiment to investigate the Diels-Alder reaction of benzenediazonium-2-carboxylate as a benzyne precursor with various anthracene derivatives, i.e.

Investigation of novel immobilized 3-(perfluoroalkanoyl)-(1R)-camphorate nickel complexes in enantioselective complexation gas chromatography.

Novel 3-(perfluoroalkanoyl)-(1R)-camphorate nickel complexes immobilized to poly(dimethylsiloxane) phases are presented. Immobilized 3-(perfluoroalkanoyl)-(1R)-camphorate nickel complexes with a trifluoromethyl (CF(3); nickel(II)-bis[(1R,4S)-3-trifluoromethanoyl-10-propylenoxycamphor]-polysiloxane Ni(tfpc)(2)@PS) and a heptafluoropropyl-substituent (C(3)F(7); nickel(II)-bis[(1R,4S)-3-heptafluorobutanoyl-10-propylenoxycamphor]-polysiloxane Ni(hfpc)(2)@PS) were synthesized, characterized and immobilized to polysiloxane. Ni(hfpc)(2)@PS was immobilized with a selector content of 38% and their enantioseparation ability was compared to selector concentrations of 4% and 20%.