The Impact of 1030 nm fs-Pulsed Laser on Enhanced Rayleigh Scattering in Optical Fibers.

This article presents a comprehensive study on the impact of irradiation optical fiber cores with a femtosecond-pulsed laser, operating at a wavelength of 1030 nm, on the signal amplitude in Rayleigh scattering-based optical frequency domain reflectometry (OFDR). The experimental study involves two fibers with significantly different levels of germanium doping: the standard single-mode fiber (SMF-28) and the ultra-high numerical aperture fiber (UHNA7). The research findings reveal distinct characteristics of reflected and scattered light amplitudes as a function of pulse energy.

Large T-cell extradural lymphoma with concurrent marked cerebrospinal fluid eosinophilia in a dog.

A 3-year-old male pit bull terrier was presented for a 4-day history of progressive tetraparesis and cervical pain. Magnetic resonance imaging confirmed an extradural mass within the left lateral vertebral canal extending from caudal C5 to mid-T2. Lumbar cerebrospinal fluid (CSF) demonstrated marked (90%) eosinophilic inflammation.

Efficacy and toxicity of carboplatin in the treatment of macroscopic mesenchymal neoplasia in dogs.

Palliative chemotherapy options for dogs with macroscopic non-osseous mesenchymal tumours are limited. The purpose of this study was to assess the response rate of these tumours to carboplatin chemotherapy. Medical records of 28 dogs treated with carboplatin for macroscopic mesenchymal neoplasia between 1990 and 2022 were retrospectively reviewed.

Clinical outcomes in cats with renal carcinoma undergoing nephrectomy: A retrospective study.

Renal carcinomas (RC) are uncommonly encountered in feline medicine. Limited information regarding clinical presentation and postoperative outcomes is available. The purpose of this multi-institutional, retrospective study was to describe the presenting features and clinical outcomes of cats with RC undergoing nephrectomy.

High-Grade, Stage 2 Mast Cell Tumors: Outcome in Dogs With Local and Systemic Therapy.

Canine mast cell tumors (MCTs) have highly variable clinical behavior, and predicting outcomes in individual dogs remains challenging. Many studies combine dogs with varying tumor grades, clinical stage, or treatments, confounding those results. The purpose of this retrospective study was to determine outcome and prognostic factors in a specific subset of dogs with high-grade, stage 2, cutaneous MCTs treated with adequate local control via surgery with or without radiation therapy and adjuvant cytotoxic chemotherapy.

A Wavelet Derivative Spectrum Length Method of TFBG Sensor Demodulation.

Fibre optic sensors using tilted fibre Bragg grating (TFBG) have high sensitivity for refractive index measurements. In order to achieve good metrological parameters of the measurement, an appropriate method of spectrum demodulation must be used. The method proposed in the article is an improvement of the spectral length algorithm.

Prospective comparison of prostatic aspirate culture and cystocentesis urine culture for detection of bacterial infection in dogs with prostatic neoplasia.

Objective: The purpose of this study was to determine whether prostatic aspirate culture is a superior method to detect infection compared to culture of urine collected by cystocentesis in dogs with prostatic neoplasia.

Materials And Methods: A prospective study was conducted and dogs with suspected or confirmed prostatic neoplasia were enrolled. Urinalysis was done and culture and antimicrobial susceptibility testing was performed on paired urine and prostatic aspirate samples collected at a single timepoint.

Population pharmacokinetics identifies rapid gastrointestinal absorption and plasma clearance of oral chlorambucil administered to cats with indolent lymphoproliferative malignancies.

Objective: To establish the pharmacokinetics of a single 2-mg oral dose of chlorambucil in cats with indolent lymphoproliferative malignancies.

Animals: 24 client-owned cats.

Procedures: Cats were assigned to 1 of 4 groups, with each group having a total of 3 sample collection time points over 12 hours after receiving a single 2-mg oral dose of chlorambucil.

Fractionated oral dosing and its effect on cyclophosphamide pharmacokinetics in dogs with high-grade multicentric lymphoma.

Cyclophosphamide (CP) is an alkylating agent commonly included in multi-drug treatment protocols for canine cancer. As a prodrug, CP requires hepatic metabolism for activation to the intermediate compound 4-hydroxycyclophosphamide (4-OHCP) which then spontaneously forms alkylating phosphoramide mustard. CP is frequently administered in a fractionated manner, with the total dose given over multiple days.

Inhaled recombinant human IL-15 in dogs with naturally occurring pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity and correlates of response.

Purpose: Although recombinant human interleukin-15 (rhIL-15) has generated much excitement as an immunotherapeutic agent for cancer, activity in human clinical trials has been modest to date, in part due to the risks of toxicity with significant dose escalation. Since pulmonary metastases are a major site of distant failure in human and dog cancers, we sought to investigate inhaled rhIL-15 in dogs with naturally occurring lung metastases from osteosarcoma (OSA) or melanoma. We hypothesized a favorable benefit/risk profile given the concentrated delivery to the lungs with decreased systemic exposure.

Single- and Double-Comb Tilted Fibre Bragg Grating Refractive Index Demodulation Methods with Fourier Transform Pre-Processing.

The development of fibre optic sensors for measuring the refractive index is related to the creation of new periodic structures and demodulation algorithms for the measured spectrum. Recently, we proposed a double-comb Tilted fibre Bragg grating (DCTFBG) structure. In this article, we analyse such a structure for measuring the refractive index in comparison to a single classical structure.

Retrospective immunohistochemical investigation of suspected non-visceral leiomyosarcoma in dogs.

Visceral leiomyosarcoma is well described in dogs, but information about non-visceral locations and prevalence is lacking. The diagnosis of leiomyosarcoma is challenging without a gold standard, and often includes the use of immunohistochemical (IHC) stains. We used defined histopathologic patterns, histochemical staining, and IHC staining for smooth muscle actin (SMA), desmin, and laminin to characterize suspected non-visceral leiomyosarcoma in dogs at a single academic institution.

Information Conversion in Measuring Channels with Optoelectronic Sensors.

The purpose of this work is the authors' attempt to identify the main phases of information transformation in measurement channels on the example of an optical measurement channel with microprocessor control. The authors include such phases: hardware implementation and analytical representation of an optical sensor's converting functions and a current-to-voltage converter; based on the methods of experimental computer science, the converting functions and sensitivity are deduced, analytical dependences for estimation of a range of measurement are obtained. It is shown that the choice of information transmission type in the microprocessor measuring channel significantly affects the speed of the measuring channel.

Outcome in dogs with curative-intent treatment of localized primary pulmonary histiocytic sarcoma.

Primary pulmonary histiocytic sarcoma (PHS) is a rare form of dendritic cell or macrophage neoplasia originating within the pulmonary parenchyma. There is limited literature describing prognosis in dogs with PHS receiving curative-intent treatment consisting of surgical excision and adjuvant chemotherapy. The primary objective of this study was to report outcomes in dogs with localized PHS treated with standardized local and systemic therapy.

Methods of Projecting Mode Amplitude Changes on the Wavelength Axis in Order to Determine the Bending Radius on the Basis of TFBG Grating Spectra.

Tilted fibre Bragg grating (TFBG) are used as sensors to determine many quantities such as refractive index, temperature, stress, rotation and bending. The TFBG spectrum contains a lot of information and various algorithms are used for its analysis. However, most of these algorithms are dedicated to the analysis of spectral changes under the influence of the refractive index.

Procedural description and prospective evaluation of short-term outcome for the use of prostatic artery embolization in dogs with carcinoma of the prostate.

Objective: To describe the procedure of prostatic artery embolization (PAE) in dogs with prostatic carcinoma and to evaluate the short-term outcome for treated dogs.

Animals: 20 client-owned dogs with prostatic carcinomas between May 2014 and July 2017.

Procedures: In this prospective cohort study, dogs with carcinoma of the prostate underwent PAE with fluoroscopic guidance.

Retrospective Evaluation of Acute Kidney Injury After Zoledronic Acid Administration to Dogs With Malignant Osteolysis.

Zoledronic acid (ZOL) is an intravenous bisphosphonate indicated for the use of hypercalcemia of malignancy and management of bony metastases. Its therapeutic effect lies in the targeting of malignant osteoclasts; however, administration can be associated with renal toxicity. The objective of this retrospective study was to evaluate the frequency and severity of acute kidney injury (AKI) following ZOL administration in a cohort of cancer-bearing dogs.

Numerical and Experimental Analysis of Matched Filter Interrogation of FBG Sensors with Large Side Lobes.

This article presents the effect of fiber Bragg gratings side lobes on interrogation systems consisting of sensor and matched filters. The conducted research shows that high-value side lobe structures applied as sensors and/or filters are characterized by some interesting properties. The paper presents both numerical analysis and experimental verification of the fiber Bragg gratings (FBG) interrogation systems with matched filters for gratings containing high side lobes.

Evaluation of accuracy for F-FDG positron emission tomography and computed tomography for detection of lymph node metastasis in canine oral malignant melanoma.

Tumour stage has been demonstrated to have prognostic significance in canine oral malignant melanoma (OMM). Various evaluation techniques of positron emission tomography/computed tomography (PET/CT) have been reported for staging of head-and-neck tumours in people, but canine-specific data are limited, and reports for CT accuracy have been variable. In this prospective study, the head/neck of client-owned dogs with cytologically or histologically diagnosed OMM were imaged with Fluorine-fluorodeoxyglucose ( F-FDG) PET/ CT.

Risk factors associated with progressive increases in serum creatinine concentrations in cats with cancer receiving doxorubicin.

Background: Azotemia occurs in cats administered doxorubicin, but risk factors have not been explored.

Objective: To determine incidence of progressive increases in serum creatinine concentration in cats with cancer receiving doxorubicin in single or multiagent chemotherapy protocols and associated risk factors.

Animals: Seventy cats with cancer receiving doxorubicin.

Intramuscular Diphenhydramine Does Not Affect Acute Doxorubicin Infusion-Related Arrhythmia Number or Severity in a Prospective Crossover Study in Canine Lymphoma: A Pilot Study.

Doxorubicin (DOX) is one of the most effective chemotherapeutics for canine high-grade lymphoma. In addition to dose-dependent chronic cardiotoxicity, DOX can trigger acute cardiac arrhythmias during drug infusion. Diphenhydramine premedication is commonly used, as histamine release is a proposed mechanism for DOX-associated arrhythmogenesis.

Overhead Transmission Line Sag Estimation Using the Simple Opto-Mechanical System with Fiber Bragg Gratings-Part 2: Interrogation System.

This article presents the use of a sensor with fiber Bragg grating along with an interrogation system used for monitoring the overhead lines' wire elongation. The possible interrogation methods based on adjusted filters were considered. In the experimental part, three types of fiber Bragg grating pairs, characterized by a small shift in spectra in pairs and gratings with exact matching, were examined.

Structural basis for virulence regulation in by unsaturated fatty acid components of bile.

The AraC/XylS-family transcriptional regulator ToxT is the master virulence activator of , the gram-negative bacterial pathogen that causes the diarrheal disease cholera. Unsaturated fatty acids (UFAs) found in bile inhibit the activity of ToxT. Crystal structures of inhibited ToxT bound to UFA or synthetic inhibitors have been reported, but no structure of ToxT in an active conformation had been determined.

Clinical features and outcome of dermal squamous cell carcinoma in 193 dogs (1987-2017).

Squamous cell carcinoma (SCC) is a frequently recognized dermal tumour in dogs and has been described as a common pathology induced by solar ultraviolet radiation exposure. Little has been published about this neoplasm with regard to clinical features and outcome in dogs. This retrospective study included 193 dogs from a single institution histopathologically diagnosed with SCC of the dermis.

Retrospective analysis of doxorubicin and prednisone as first-line therapy for canine B-cell lymphoma.

Background: A doxorubicin (DOX)-based chemotherapy protocol, CHOP, is the most effective treatment for canine high-grade B-cell lymphoma; however, the cost and time requirements associated with this protocol are not feasible for many pet owners. An alternative treatment option is the use of DOX, the most effective drug, in combination with prednisone. Prior studies with single-agent DOX included dogs with T-cell lymphoma, a known negative prognostic factor, which may have resulted in shorter reported survival times than if dogs with B-cell lymphoma were analyzed separately.