[Hypothalamo-hypophyseo-gonad system function in boys with an abnormal puberty syndrome].

The blood basal testosterone-, LH-, FSH levels, 17-CS and 17-HOCS excretion with the urine, circadian rhythms of testosterone-, LH- and FSH secretion were studied in 21 boys, aged 11 to 13 years, with abnormal puberty, manifesting in pronounced sexual hirsutism in the presence of infantile testicles. Functional tests, using chorionic gonadotropin, clomiphene citrate and spironolactone, were performed, as well. The blood level of testosterone and the change in its circadian secretion were markedly reduced in all the subjects under examination.

[Androgenic function of the testes and gonadotropic activity of the pituitary gland in various forms of cryptorchism in children and adolescents].

Biochemical and radioimmunoassay of testosterone content in the blood and urine, epitestosterone and 17-CS level in the urine of 80 boys has shown, that the ovarian androgenic function is reduced in all the forms of cryptorchidism. The potential testis reserves are progressively lowered with the age in patients with bilateral and false retention and remain unchanged in unilateral cryptorchidism. In the absolute majority of patients the change in gonadotropic hormone production is noted, manifesting in the decreased and/or increased LH and FSH content in the blood of different patients, that is seemed to reflect heterogeneity of cryptorchidism pathogenetic forms.

[Blood serum immunoglobulins in small boys and adolescents with hypogonadism].

The immunoglobulin (Ig) concentration was studied in the blood serum of 31 boys with secondary hypogonadism. There was revealed a marked fall in the content of Ig of the A, M, and G classes, particularly of the M class, in all the patients before the treatment. After disappearance of the clinical hypogonadism signs and normalization of the blood testosterone level under the effect of chorionic gonadotropin therapy the plasma Ig concentration was found to be restored to the normal; the greatest relative elevation was revealed in case of IgM.