Assessment of the disease severity in patients hospitalized for COVID-19 based on the National Early Warning Score (NEWS) using statistical and machine learning methods: An electronic health records database analysis.

Background: The coronavirus disease 2019 (COVID-19) was a cause of concern in the healthcare system and increased the need for disease severity indicators. However, they still vary in use to evaluate in-hospital outcomes and severity. The National Early Warning Score (NEWS) is routinely used to evaluate patient health status at the hospital.

Exploring myocardial fibrosis in severe aortic stenosis: echo, CMR and histology data from FIB-AS study.

Myocardial fibrosis in aortic stenosis is associated with worse survival following aortic valve replacement. We assessed myocardial fibrosis in severe AS patients, integrating echocardiographic, cardiovascular magnetic resonance (CMR) and histological data. A total of 83 severe AS patients (age 66.

Prognostic value of myocardial fibrosis in severe aortic stenosis: study protocol for a prospective observational multi-center study (FIB-AS).

Background: Adverse cardiac remodeling with a myocardial fibrosis as a key pathophysiologic component may be associated to worse survival in aortic stenosis (AS) patients. Therefore, with the application of advanced cardiac imaging we aim to investigate left ventricular myocardial fibrosis in severe AS patients undergoing aortic valve replacement (AVR) and determine its impact with post-intervention clinical outcomes.

Methods: In a prospective, observational, cohort study patients with severe AS scheduled either for surgical or transcatheter AVR will be recruited from two tertiary heart centers in Denmark and Lithuania.

Correction to: Prevalence and prognostic value of late gadolinium enhancement on CMR in aortic stenosis: meta-analysis.

The original version of this article, published on 12 August 2019, unfortunately contained a mistake. The funding note was incorrect; the correct funding note is given below.

Prevalence and prognostic value of late gadolinium enhancement on CMR in aortic stenosis: meta-analysis.

Objectives: The aim of this study was to investigate the prevalence and prognostic value of late gadolinium enhancement (LGE), as assessed by cardiovascular magnetic resonance (CMR) imaging, in patients with aortic stenosis.

Methods And Results: A systematic search of PubMed and EMBASE was performed, and observational cohort studies that analysed the prevalence of LGE and its relation to clinical outcomes in patients with aortic stenosis were included. Odds ratios were used to measure an effect of the presence of LGE on both all-cause and cardiovascular mortality.

High-risk profile in a region with extremely elevated cardiovascular mortality.

Introduction: Although mortality rates from cardiovascular diseases have shown a remarkable decline in many western countries, cardiovascular mortality in Lithuania has remained high. It is widely accepted that half of the decline in cardiovascular mortality can be attributed to favourable changes in modifiable risk factors.

Methods: In 2006, the Lithuanian High Cardiovascular Risk Programme was started.

Quantitative approach using multiple single parameters versus visual assessment in dobutamine stress echocardiography.

Background: A number of myocardial Doppler-derived velocity, strain myocardial imaging parameters (DMI) and speckle tracking imaging (STI) have been proposed for the quantification of myocardial ischemia during stress echocardiography. The purpose of the study was to identify the best single ultrasound quantitative parameter for prediction of significant coronary stenosis and compare it with visual assessment during dobutamine stress echocardiography (DSE).

Methods: Prospective analysis included data of 151 patients (age 61.

Value of scar imaging and inotropic reserve combination for the prediction of segmental and global left ventricular functional recovery after revascularisation.

Background: This study sought to prospectively and directly compare three cardiovascular magnetic resonance (CMR) viability parameters: inotropic reserve (IR) during low-dose dobutamine (LDD) administration, late gadolinium enhancement transmurality (LGE) and thickness of the non-contrast-enhanced myocardial rim surrounding the scar (RIM). These parameters were examined to evaluate their value as predictors of segmental left ventricular (LV) functional recovery in patients with LV systolic dysfunction undergoing surgical or percutaneous revascularisation. The second goal of the study was to determine the optimal LDD-CMR- and LGE-CMR-based predictor of significant (≥ 5%) LVEF improvement 6 months after revascularisation.

[Pleurectomy and decortication in chronic tuberculous pleuritis and pleural empyema].

The study covered 105 patients with chronic tuberculous pleurisy and empyema who had undergone surgery. Reparative pleurectomies with lung decortication were made in all the patients. Four groups of patients operated on in different periods were analyzed.

[Means for volumetric fire extinguishing in inhabited facilities].

The authors discuss the problem concerning the substitution of ozone-destroying fire extinguishing halogen hydrocarbons 13B1, 12B1 and 114B2 with alternative means of volumetric fire extinguishing. The toxicological-and-hygienic characteristics of chladon 13B1 and of the new ozone-harmless extinguishers (chladons 124B1 and 125, sulphur hexafluoride and aerosol-forming means of volumetric fire extinguishing) are shown.

[Indications for surgical treatment of chronic and encysted pleurisy].

If exudative pleurisy developed unfavourably with the formation of encystment, the development of massive pleural impositions, the deterioration of cardiorespiratory functional parameters, reparative operations, such as pleurectomy with decortication, were performed at month 3-4 of the onset of the disease with the minimum number of intra- and postoperative complications, with the more rapid and proper anatomic and functional recovery. Postoperative complications occurred in 75% of patients at months 1-2 of the disease, in 25-30% at months 5-12.

[Clinical use of artificial heart valve PLANIKS].

The first clinical results of a new repeated-disc artificial heart valve PLANIKS application were summarized. In prosthesis the useful hydrodynamic parameters, durability, reliability, convenience and easiness while implantation conduction are combined harmoniously, the sterility is guaranteed. PLANIKS permits to correct adequately the hemodynamics disorders in the early postoperative period and may be recommended for the clinical practice use.

[The laboratory diagnosis of atherogenic disorders in servicemen].

In order to calculate the atherogenic coefficient the authors have made a comparative estimation of methods for determining alfa-cholesterin in serum applying various temperature regimes during sedimentation of beta and pre-beta-lipoproteids. It was found out that the complete sedimentation of beta and pre-beta-lipoproteids could be obtained after incubation of specimen into the ice bath for 30 min. (t 0-4 degrees C) with further centrifugation at room temperature.

[Xanthine oxidase of the cerebrospinal fluid in patients with craniocerebral trauma].

The authors studied the activity of xanthine oxidase (XO) and xanthine dehydrogenase (XDG) in the cerebrospinal fluid (CSF) of patients with craniocerebral trauma (CCT). XO and XDG activity in CSF appeared in moderate and severe CCT. XO in CSF was predominantly of cerebral origin.

[Creatine phosphokinase in the cerebrospinal fluid of patients with acute meningitis].

A study is presented of the general activity and isoenzymatic spectrum of creatine phosphokinase (CPK) in the cerebrospinal fluid (CSF) in patients with acute meningitis of different etiology. The enzymatic activity proved to be increased due to the cerebral (CPK-BB) isoform. Liberation of CPK-BB from the brain tissue and its penetration into the intercellular fluid and then into the CSF was related to the functional-structural changes in the cellular membranes of the brain in meningitis.

[Cyclic adenosine monophosphate in the cerebrospinal fluid of patients with brain trauma and diseases].

The authors studied adenosine 3,5-cyclic monophosphate (cAMP) in the cerebrospinal fluid (csf) of patients with craniocerebral trauma (CCT), ischemic stroke, and brain tumors. A statistically significant increase of cAMP in csf of patients with moderate and severe CCT was revealed. In unfavourable outcomes of severe CCT the increase of cAMP continued to the time of death.

[Creatine phosphokinase in the cerebrospinal fluid of patients with stroke in the acute period].

Creatine phosphokinase (CP) activity was increased in the cerebrospinal fluid (CSF) in stroke patients as compared to a group of control patients. CP activity tended to be higher in hemorrhagic stroke as compared to ischemic one. The brain isoenzyme CP has a major impact on its total activity (above 75%).

[Creatine kinase isoenzymes in the diagnosis of acute cranio-cerebral trauma].

The cerebrospinal fluid (CSF) creatine kinase (CK) activity and isozymic spectrum (EC 2.7.3.