Publications by authors named "Skoglund Kristofer"
Purpose: We examined whether end-to-end deep-learning models could detect moderate (≥50%) or severe (≥70%) stenosis in the left anterior descending artery (LAD), right coronary artery (RCA) or left circumflex artery (LCX) in iodine contrast-enhanced ECG-gated coronary CT angiography (CCTA) scans.
Methods: From a database of 6293 CCTA scans, we used pre-existing curved multiplanar reformations (CMR) images of the LAD, RCA and LCX arteries to create end-to-end deep-learning models for the detection of moderate or severe stenoses. We preprocessed the images by exploiting domain knowledge and employed a transfer learning approach using EfficientNet, ResNet, DenseNet and Inception-ResNet, with a class-weighted strategy optimised through cross-validation.
Background And Aims: The long-term outcomes of percutaneous coronary intervention (PCI) vs. coronary artery bypass grafting (CABG) in patients with non-ST-segment elevation myocardial infarction (NSTEMI) and multivessel disease remain debated.
Methods: The Swedish Web-system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies registry was used to analyse 57 097 revascularized patients with NSTEMI with multivessel disease in Sweden from January 2005 to June 2022.
Article Synopsis
- * A study analyzed 15,856 ECGs from emergency patients in Sweden and trained a convolutional neural network (ResNet) to predict troponin elevation, achieving an accuracy of 71.43% and a high negative predictive value of 0.8660.
- * The model's promising performance suggests that similar neural networks could be used in emergency settings for rapid triage of patients suspected of having heart issues.
Aims: There is scarce knowledge about the association between social factors and mid-term outcome in older patients undergoing transaortic valve implantation (TAVI). Our aim in this study is to explore associations between marital status, educational level, and mortality risk in patients after TAVI.
Methods And Results: Patients aged ≥65 who underwent TAVI in Sweden during 2014-2020 were identified from the SWEDEHEART registry.
Article Synopsis
- Takotsubo syndrome (TTS) is a serious condition mimicking heart attacks, often triggered by stress, and has high rates of morbidity and mortality.
- This study utilized data from the Swedish Coronary Angiography and Angioplasty Registry between 2015-2022, employing machine learning (specifically gradient boosting) to identify factors predicting 30-day mortality in TTS patients.
- Results revealed that the treating hospital was the strongest predictor of mortality, followed by factors like the clinical reason for angiography, creatinine levels, Killip class, and patient age, highlighting the need for tailored treatments based on these predictors.
Aims: Individuals with congenital heart disease (CHD) are at an increased risk for cancer. As cancer survival rates improve, the prevalence of late side effects, such as heart failure (HF), is becoming more evident. This study aims to evaluate the risk of developing HF following a cancer diagnosis in patients with CHD, compared with those without CHD and with CHD patients who do not have cancer.
View Article and Find Full Text PDFBackground: No previous study has evaluated patients attitudes towards inclusion in an ongoing cardiac arrest clinical trial. The aim of this study was to assess patientś willingness and motives to participate in the ongoing randomized controlled drug trial "Vasopressin and Steroids in addition to Adrenaline in cardiac arrest" (VAST-A trial) in case of an in-hospital cardiac arrest (IHCA).
Objectives: Hospitalized patients, men ≥ 18 and women ≥ 50 years, were asked for informed consent for inclusion in the VAST-A trial in case of an IHCA, the reason for approving or declining inclusion in the trial and baseline characteristics.
Corrigendum to "Risk of cancer in young and older patients with congenital heart disease and the excess risk of cancer by syndromes, organ transplantation and cardiac surgery: Swedish health registry study (1930-2017)" [The Lancet Regional Health-Europe 18 (2022) 100407].
Lancet Reg Health Eur
May 2024
Article Synopsis
- The text indicates that there is a correction made to a previously published article.
- The article can be identified using its DOI (Digital Object Identifier) number: 10.1016/j.lanepe.2022.100407.
- The correction is likely to address an error or oversight from the original publication.
Article Synopsis
- Patients with congenital heart disease (CHD) have a higher cancer risk and were found to have a lower median age of cancer diagnosis (13 years) compared to non-CHD controls (24.6 years).
- Despite the increased cancer incidence, the overall mortality risk for CHD patients with cancer is not significantly different from that of non-CHD patients when excluding those with genetic syndromes and transplant recipients.
- The most common fatal cancers among CHD patients included unspecified cancers, eye and central nervous system tumors, and blood-related malignancies, with 18.3% of CHD patients diagnosed with cancer ultimately dying from it.
Socioeconomic factors and long-term mortality risk after surgical aortic valve replacement.
Int J Cardiol Cardiovasc Risk Prev
December 2023
Background: There is scarce knowledge about the association between socioeconomic status and mortality in patients undergoing surgical aortic valve replacement. This study explores the associations between income, education and marital status, and long-term mortality risk.
Methods: In this national registry-based observational cohort study we included all 14,537 patients aged >18 years who underwent isolated surgical aortic valve replacement for aortic stenosis in Sweden 1997-2020.
Article Synopsis
- The study examined the survival rates of patients with left-sided valvular heart disease (VHD) after experiencing out-of-hospital cardiac arrest (OHCA) through data from the Swedish Registry for Cardiopulmonary Resuscitation.* -
- Among the cases analyzed (55,615 patients), those with aortic stenosis (AS) showed significantly lower survival rates (5.2%) compared to aortic regurgitation (AR, 10.4%), mitral regurgitation (MR, 9.2%), and those without VHD (11.4%).* -
- While survival after 30 days was worse for AS patients, neurological outcomes for AS survivors were similar to those without VHD
Objective: This study aimed to examine the association between exercise workload, resting heart rate (RHR), maximum heart rate and the risk of developing ST-segment elevation myocardial infarction (STEMI).
Methods: The study included all participants from the UK Biobank who had undergone submaximal exercise stress testing. Patients with a history of STEMI were excluded.
Article Synopsis
- Despite advances in short-term survival rates for Out-of-Hospital Cardiac Arrest (OHCA), long-term survival remains under-researched, particularly concerning factors influencing it.
- A study analyzed 1-year outcomes of patients who survived OHCA and were released from hospitals, using a machine learning model that considered 886 factors to predict re-arrest or death.
- Results showed that around 18% of the 5098 patients experienced either a re-arrest or death within a year, and a simplified model with 15 key variables provided predictive capabilities nearly equivalent to the comprehensive model.
Background: Aortic stenosis is the most common valvular disease, and its prevalence is increasing due to the ageing population. Transcatheter aortic valve replacement (TAVR) is the recommended method when treating frail, older patients. Knowledge of what motivates older patients to undergo TAVR is important, in order to meet patients' expectations.
View Article and Find Full Text PDFBackground: Identifying signs of medical distress prior to in-hospital cardiac arrest (IHCA) is important to prevent IHCA and improve survival. The primary objective of this study was to investigate the association between signs of medical distress present within 60 minutes prior to cardiac arrest and survival after cardiac arrest.
Methods: The register-based cohort study included adult patients (≥18 years) with IHCA in the Swedish Registry of Cardiopulmonary Resuscitation (SRCR) from 2017-01-01 to 2020-07-15.
Background: Increasing survival of patients with congenital heart disease (CHD) will result in an increased risk of age-dependent acquired diseases later in life. We aimed to investigate the risk of cancer in young and older patients with CHD and to evaluate the excess risk of cancer by syndromes, organ transplantation and cardiac surgery.
Methods: Patients with CHD born between 1930 and 2017 were identified using Swedish Health Registers.
Associations between medical therapy after surgical aortic valve replacement for aortic stenosis and long-term mortality: a report from the SWEDEHEART registry.
Eur Heart J Cardiovasc Pharmacother
December 2022
Aims: The association between the use of statins, renin-angiotensin system (RAS) inhibitors, and/or β-blockers and long-term mortality in patients with aortic stenosis (AS) who underwent surgical aortic valve replacement (SAVR) is unknown.
Methods And Results: All patients with AS who underwent isolated first-time SAVR in Sweden from 2006 to 2017 and survived 6 months after discharge were included. Individual patient data from four mandatory nationwide registries were merged.
Background And Objectives: During the last decades, the survival rates in patients with congenital heart disease have increased dramatically, particularly in patients with complex heart malformations. However, the survival in patients with simple defects is still unknown. We aimed to determine the characteristics and the risk of mortality in patients with isolated pulmonary valve stenosis (PS).
View Article and Find Full Text PDFCongenitally corrected and surgical atrial redirected transposition of the great arteries (TGA) represents states where the morphological right ventricle serves as a systemic ventricle (S-RV). The S-RV is prone to failure, but data on medical treatment on this problem is limited. The purpose of this study was to evaluate the survival in adults with S-RV, with or without heart failure treatment.
View Article and Find Full Text PDFImportance: Adult patients with congenital heart disease (CHD) have an increased incidence of cancer, presumably owing to repeated radiation exposure, genetic predisposition, or repeated stress factors during heart interventions. However, there are limited data on the risk of cancer in children and young adults with CHD compared with the general population.
Objective: To determine the risk of developing cancer from birth to age 41 years among patients with CHD compared with healthy matched controls.
Objective: Heart failure (HF) is a common cause of hospitalisation and death in adults with congenital heart disease (CHD). However, the risk of HF in young patients with CHD has not been determined.
Methods: By linkage of national patient registers in Sweden, we identified 21 982 patients with CHD born between 1970 and 1993, and compared these with 10 controls per case.
Background: Among patients with congenital heart disease, implantation of a valved conduit is common practice for surgical reconstruction of malformations involving the right ventricular outflow tract (RVOT). The conduit has limited durability, and treatments with surgical replacement and transcatheter pulmonary valve replacement (TPVR) are common. Previous studies indicate that TPVR, despite being a less invasive alternative, is not used for the majority of these patients.
View Article and Find Full Text PDFBackground: Patients with congenital heart disease (CHD) are assumed to be vulnerable to atrial fibrillation (AF) as a result of residual shunts, anomalous vessel anatomy, progressive valvulopathy, hypertension, and atrial scars from previous heart surgery. However, the risk of developing AF and the complications associated with AF in children and young adults with CHD have not been compared with those in control subjects.
Methods: Data from the Swedish Patient and Cause of Death registers were used to identify all patients with a diagnosis of CHD who were born from 1970 to 1993.