Methylseleninic Acid Elevating the Nrf2-GPX4 Axis Relieves Endothelial Dysfunction and Ferroptosis Induced by Arsenic Exposure.

Chronic exposure to arsenic (As), a ubiquitous contaminant, poses deleterious health risks to humans, including cardiovascular disease. Recent studies have implicated ferroptosis, in which the essential micronutrient selenium (Se) plays a crucial role, in several As-induced pathological processes. However, whether Se can counteract As-induced endothelial dysfunction through ferroptosis remains unclear.

The impact of core training combined with breathing exercises on individuals with chronic non-specific low back pain.

Background: Chronic non-specific low back pain (CNLBP) is a common condition, defined as pain lasting more than 3 months between the lower thoracic margin and gluteal folds, without identifiable tissue damage. Despite its low disability rate, the complex etiology and high recurrence impose significant health and socioeconomic burdens. According to European LBP guidelines, exercise therapy is the preferred treatment for CNLBP.

Dynamics of Cell Fate Decisions during Chemically Induced Multi-Lineage Trans-Differentiation at Single-Cell Level.

Cell trans-differentiation offers a powerful means to manipulate cell identities. By exposing cells to a combination of small molecules (SMs), cell trans-differentiation can be induced in a simple and cost-effective manner. However, a comprehensive atlas detailing chemical-induced cell trans-differentiation across multiple cell fates has yet to be established.

A randomised controlled trial to evaluate the efficacy of a multi-step oral hygiene product intervention to improve oral health in partial denture wearers.

Objectives: This study was designed to evaluate the effectiveness of a multi-step oral hygiene intervention among removal partial denture (RPD) wearers.

Methods: A 12-week, single-blind, randomised, 2-armed, parallel-group, controlled trial was conducted with 49 RPD-wearing participants with mild-moderate gingivitis. The intervention group received stannous fluoride toothpaste, sodium fluoride mouth rinse, and an antibacterial denture cleanser foam.

Efficacy of non-pharmacological interventions for the prevention of antenatal depression: A systematic review and network meta-analysis.

Background: Preventing the occurrence of prenatal depression is one of the most important possibilities for reducing the disease burden of maternal depression. The preventive effects of various non-pharmacological interventions on prenatal depression remain insufficiently understood.

Aims: To assess the efficacy of different non-pharmacological measures in preventing prenatal depression via a network analysis.

Immunomechanobiology: Engineering the Activation and Function of Immune Cells with the Mechanical Signal of Fluid Shear Stress.

Immunomechanobiology, the study of how physical forces influence the behavior and function of immune cells, is a rapidly growing area of research. It is becoming increasingly recognized that mechanical stimuli, such as fluid shear forces, are a critical determinant of immune cell regulation. In this review, we discuss the principles and significance of various mechanical forces present within the human body, with a focus on fluid shear flow and its impact on immune cell activation and function.

Intradialytic Hypotension Frequency Prediction Using Generalizable Neighborhood Reasoning on Temporal Patient Knowledge Graph.

Intradialytic hypotension (IDH) is a common complication among hemodialysis patients, adversely affecting quality of life and elevating mortality risk. IDH prediction enables physicians to take proactive measures, effectively reducing its occurrence. However, most prediction works rely on machine learning models, with a focus on real-time or session-level IDH.

Prediction of primary Hypertension in Primary Health Care Settings in Coastal Karnataka Using Artificial Neural Network.

Background: Hypertension, characterized by chronically elevated blood pressure, poses a significant global health burden. Its prevalence, a critical public health concern, necessitates ac-curate prediction models for timely intervention and management.

Aim: The proposed approach leverages the capability of an Artificial Neural Network to capture complex patterns and non-linear relationships within the time series data, allowing for the devel-opment of a robust forecasting model to predict Hypertension.

Ultrasound-activated nano-oxygen sensitizer for sonodynamic-radiotherapy of esophageal cancer.

: owing to the intricate nature, variability, and persistent oxygen-deficient environment associated with esophageal cancer (EC) tissues, radiotherapy (RT) sometimes doesn't work as well because some cancer cells can resist the radiation to a certain extent. This can lead to the cancer coming back in the same spot or even making the treatment ineffective. The integration of RT with oxygenation strategies is a common approach in cancer treatment.

Genome-Wide Association Integrating a Transcriptomic Meta-Analysis Suggests That Genes Related to Fat Deposition and Muscle Development Are Closely Associated with Growth in Huaxi Cattle.

Growth traits are among the most important economic phenotypes targeted in the genetic improvement of beef cattle. To understand the genetic basis of growth traits in Huaxi cattle, we performed a genome-wide association study (GWAS) on body weight, eye muscle area, and back fat thickness across five developmental stages in a population of 202 Huaxi cattle. Additionally, publicly available RNA-seq data from the longissimus dorsi muscle of both young and adult cattle were analyzed to identify key genes and genetic markers associated with growth in Huaxi cattle.

Improvement Effects of Different Afforestation Measures on the Surface Soil of Alpine Sandy Land.

Desertification severely impacts soil environments, necessitating effective control measures to improve sandy soil. On the alpine sandy land of Gonghe Basin, taking bare land containing mobile sand dunes (LD) as a reference, surface soil undergoing four afforestation measures, namely a + (WLYY), + (SLWL), + (SHNT), and (NT80), was studied, with soil physicochemical properties and enzyme activity measured and the bacterial community structure analyzed using Illumina high-throughput sequencing. Compared to LD, all four afforestation measures significantly reduced the sand content, while increasing soil total carbon, total nitrogen, organic matter, alkali-hydrolyzable nitrogen, and available potassium.

Effective enhancement of copper selective removal from sodium alginate-based gel adsorbent by dual construction of slit-shaped structure and internal channel.

The Cu(II) treatment in water environment by adsorption has become a major strategy for water pollution control and water resource protection. In view of the planar configuration characteristics of Cu(II) complex, the construction and optimization of adsorbent's internal structure to achieve improved adsorption performance is still a problem worth exploring. Herein, polyvinyl alcohol (PVA) is introduced into graphene oxide/sodium alginate (GO/SA) gel system to obtain PVA/GO/SA gel material, which not only achieves the construction of slit-shaped structure by self-interlayer stacking for GO nanosheets and its cross-linking with SA, but effectively promotes formation of high cross-linking density internal channels by the introduction of PVA, thus achieving the efficacious and selective Cu(II) removal.

Corrigendum to "POS-074 SERUM NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN, EARLY BIOMARKER OF ACUTE KIDNEY INJURY IN ASPHYXIATED TERM NEONATES AT LAGOS STATE UNIVERSITY TEACHING HOSPITAL" [ Volume 7, Issue 2, Supplement, February 2022, Page S31].

[This corrects the article DOI: 10.1016/j.ekir.

Text mining of outpatient narrative notes to predict the risk of psychiatric hospitalization.

The primary purpose of this paper is to investigate whether text mining of the outpatient narrative notes for patients with severe and persistent mental illness (SPMI) can strengthen the predictions concerning the probability of an upcoming hospital readmission. A five-year study of all clinical notes for SPMI patients at the outpatient clinic of a tertiary hospital was conducted. The clinical notes were studied using ensemble classification i.

Discrepancy in efficiency scores due to sampling error in data envelopment analysis methodology: evidence from the banking sector.

Background: Data Envelopment Analysis (DEA) methodology is considered the most suitable approach for relative performance efficiency calculation for banks as it is believed to be superior to traditional ratio-based analysis and other conventional performance evaluations. This study provides statistical evidence on the sampling error that can creep into performance evaluation studies using the DEA methodology. Inferences are drawn based on samples, and various preventive measures must be taken to eliminate or avoid sampling errors and misleading results.

Clinical features and outcomes of unresectable locally advanced lung adenocarcinoma with uncommon mutations: a retrospective multi-center Chinese study.

Background: Uncommon epidermal growth factor receptor () gene mutant locally advanced non-small cell lung cancer (NSCLC) has been poorly documented in the literature. Our study aimed to investigate the clinical features and outcomes associated with these mutations.

Methods: A multi-center retrospective study was conducted to review 511 patients with mutant unresectable stage III lung adenocarcinoma, treated between 2012 and 2018 across 12 Chinese institutions.

/BRG1-deficient non-small cell lung cancer: clinical, imaging, pathological features, and follow-up results of 23 patients.

Background: /BRG1-deficient non-small cell lung cancer (S/B-d NSCLC) is a rare subtype of non-small cell lung cancer (NSCLC). The aim of this study was to investigate the clinical, imaging, serum tumor marker, and pathological features of S/B-d NSCLC, particularly computed tomography (CT) and F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) scan features.

Methods: Our analysis included 23 patients with pathologically confirmed S/B-d NSCLC from January 2021 to December 2023.

Perioperative or postoperative adjuvant oxaliplatin with S-1 versus adjuvant oxaliplatin with capecitabine in patients with locally advanced gastric or gastro-oesophageal junction adenocarcinoma undergoing D2 gastrectomy (RESOLVE): final report of a randomised, open-label, phase 3 trial.

Background: The multicentre RESOLVE trial examined the efficacy of perioperative and postoperative S-1 and oxaliplatin (SOX) compared with postoperative capecitabine and oxaliplatin (CapOx) in gastric or gastro-oesophageal junction cancer. Initial analyses did not encompass overall survival owing to the immature data. This paper provides an updated analysis of the survival data from the RESOLVE trial.

A pilot randomised study to compare sub-lingual and vaginal routes of low-dose misoprostol following two sequential doses of mifepristone for second-trimester medical abortion.

Primary Objective: A randomized study to compare the induction abortion interval (IAI) using two different routes of Low-dose misoprostol administration Sublingual (S/L) and vaginal, after priming with two sequential doses of mifepristone for second-trimester medical abortion.

Study Design: After randomization in two groups, participants received two doses of mifepristone (200 mg) 24 h apart. On day 3, 200mcg of misoprostol was given by S/L route to group 1 and by vaginal route to group 2, (400mcg among women with gestation ≤16 weeks) and every 6 hours for a maximum of 3 doses.

The dual selective adsorption mechanism on low-concentration Cu(II): Structural confinement and bridging effect.

In this study, sulfur was introduced into the graphene oxide-based aerogel system based on the theory of bridging effect, and an oxygen-sulfur synergistic system was established to realize the dual-mechanism selective adsorption to low-concentration Cu(II) with slit structure and targeted binding sites. Based on the difference of chemical properties between organic acids and surfactants, the surface of graphene oxide (GO) was functionalized to realize the regulation of the order of its lamellar structure and the construction of carbon defects. On this basis, sulfur source modified GO-based aerogel was created to accomplish selective adsorption to low-concentration Cu(II) by combining the self-accumulation of montmorillonite and GO with the cross-linking mechanism of Ca(II) and sodium alginate.

Gastric cancer metastasizing to the male reproductive system.

A 71-year-old male patient underwent a radical gastrectomy for gastric cancer two years prior and subsequently received regular postoperative chemotherapy with capecitabine and oxaliplatin. Six months before admission, he experienced the onset of swelling in the right inguinal region, accompanied by pain in the right lower abdomen during ambulation. He was admitted to the hospital due to the progressive enlargement of the swelling and the onset of severe abdominal pain.

Evaluation of gestational nonpersistent pesticide exposure with newborn size and gestational length in rural Ghana using a novel time-varying extension of multiple informant models.

Background: Gestational pesticide exposure may negatively affect newborn outcomes. Prior results evaluating nonpersistent pesticides are inconsistent.

Objective: To examine associations between gestational exposure to nonpersistent pesticides and newborn outcomes and identify critical windows of susceptibility.

Nest site selection during the second breeding attempt in Japanese tits (Parus minor): effects of nest site characteristics.

Numerous investigations focusing on nest site selection among multiple-brooded bird species have revealed a common trend: breeders frequently return to their first nest sites for another brood during the same breeding season. This behavior suggests a strong preference for familiar locations, which may offer advantages such as increased safety, resource availability, and the efficiency of parental care. However, there were also instances where breeders moved to a new nest site.

Hydrogel inspired by "adobe" with antibacterial and antioxidant properties for diabetic wound healing.

With the aging population, the incidence of diabetes is increasing. Diabetes often leads to restricted neovascularization, antibiotic-resistant bacterial infections, reduced wound perfusion, and elevated reactive oxygen species, resulting in impaired microenvironments and prolonged wound healing. Hydrogels are important tissue engineering materials for wound healing, known for their high water content and good biocompatibility.