PECULIARITIES OF THE SECOND MESIOBUCCAL CANAL IN MAXILLARY FIRST MOLAR: A RETROSPECTIVE ANALYSIS.

Unlabelled: The first maxillary molar is one of the most difficult teeth for endodontical treatment; it presents the highest failure rates due to the impossibility of locating and treating the second mesiobuccal canal (MB2). The aim of our work was study of second mesiobuccal canal in maxillary first molar and compare obtained data with literature sources for increasing the efficiency of treatment.

Materials And Methods: The study involved 59 patients with exacerbation of chronic pulpitis or chronic periodontitis who were distributed according to age: 14-20 years, 21-30 years and 31-40 years.

Glioblastoma Multiforme: Sensitivity to Antimicrobial Peptides LL-37 and PG-1, and Their Combination with Chemotherapy for Predicting the Overall Survival of Patients.

Glioblastomas (GBMs) are the most malignant and intractable of all cancers, with an unfavorable clinical prognosis for affected patients. The objective was to analyze the sensitivity of GBM cells to the antimicrobial peptides (AMPs) cathelicidin (LL-37) and protegrin-1 (PG-1), both alone and in combination with chemotherapy, to predict overall survival (OS) in the patients. The study was conducted on 27 GBM patients treated in the neurosurgical department of the Almazov Medical Research Centre (Saint Petersburg, Russia) from 2021 to 2024.

ETIOLOGY, DIAGNOSIS AND TREATMENT OF MUSCLE-ARTICULAR DYSFUNCTION OF THE TEMPOROMANDIBULAR JOINT IN ADOLESCENCE.

Unlabelled: Etiologic and pathogenetic aspects cause the most contentious issue in the study of temporomandibular joint (TMJ) syndrome in childhood and adolescence. Some researchers have linked the emergence of this group of diseases with abnormal occlusion, others have more emphasis on the age characteristics of a growing organism, or rather on a number of morphological and psychomotor processes arising and ending at puberty and cause physiological abnormalities in the growing organism. The aim of the study was to improve the method of complex treatment of TMJ dysfunction in adolescence by exploring its development factors with early diagnosis methods.

Expression of molecular markers and synergistic anticancer effects of chemotherapy with antimicrobial peptides on glioblastoma cells.

Objective: Glioblastoma multiforme (GBM) is the most aggressive and fatal malignant primary brain tumor. The enhancement of the survival rate for glioma patients remains limited, even with the utilization of a combined treatment approach involving surgery, radiotherapy, and chemotherapy. This study was designed to assess the expression of IDH1, TP53, EGFR, Ki-67, GFAP, H3K27M, MGMT, VEGF, NOS, CD99, and ATRX in glioblastoma tissue from 11 patients.

Anticancer Effect of Cathelicidin LL-37, Protegrin PG-1, Nerve Growth Factor NGF, and Temozolomide: Impact on the Mitochondrial Metabolism, Clonogenic Potential, and Migration of Human U251 Glioma Cells.

Glioblastoma (GBM) is one of the most aggressive and lethal malignancy of the central nervous system. Temozolomide is the standard of care for gliomas, frequently results in resistance to drug and tumor recurrence. Therefore, further research is required for the development of effective drugs in order to guarantee specific treatments to succeed.

[Gemistocytic astrocytomas].

Gemistocytic astrocytomas (GA) are a variant of diffuse astrocytomas GII (WHO, 2016). Like all diffuse astrocytomas, GA recur with time, which is often accompanied by malignant degeneretion into the anaplastic astrocytoma GIII or to the secondary glioblastoma GIV. However, the progression-free survival and overall survival in patients with GA is less than in patients with diffuse astrocytomas.

[A combined lesion of the digestive organs and chronic inflammatory diseases of the large intestine].

An analysis was carried out of 222 medical records and autopsies from patients with inflammatory diseases of the large intestine, the immediate causes of death of whom were different disorders. The incidence of hepatitis running an active course correlated with age of patients and came up to 58.8% in the group of subjects 20 to 40 years old.

[Methods of treatment of the mammary gland cancer in its initial stage].

The results of treatment of 1231 women patients with the mammarial gland cancer of initial stages was analysed, in 151 of them the organ-preserving operation was performed. The results of treatment with five-year follow-up, using the organ-preserving operations do not cede to such in application of classical mastectomy.

[An epidemiological analysis of peptic ulcer morbidity among the servicemen in the enlisted service of the Armed Forces of Ukraine].

Data are submitted from a time-related analysis of peptic ulcer incidence among enlisted men of the Armed Forces of Ukraine. Peptic ulcer in the Armed Forces of Ukraine has been shown to be a major illness associated with substantial labour resource losses that total in certain years 28.3 percent of the digestive diseases-related unfitness for work, with the specific weight of ulcer of the stomach not exceeding 0.

[The treatment of edematous-infiltrative forms of breast cancer by using thermochemo- and thermoradiotherapy].

The study included 157 patients with edematous-infiltrative breast cancer. Thermochemo- and thermoradiotherapy were shown to modify (increase) cancer cell sensitivity to antitumor treatment and thus improve tumor response.

[Surgery of pathologic fractures of the metacarpal bones in children].

The experience with the use of a method of bone plasty developed by the authors in the treatment of 13 children with a pathologic fracture of metacarpal bones is summarized. In follow up of from 1 to 6 years, the complete reconstruction of a transplant with replacing the defects by bone tissue which do not differ in structure from the own one was noted. A hand function restored to the full volume.

[Osteoplastic operations in the treatment of tumors of finger phalanx bones in children].

In the article is proposed the method of treatment of finger phalanx tumors in children, localized in the area of growth zones. By application of the proposed method the authors operated on 12 children aged 3-15 years in connection with the benign tumors of finger phalanx bones. Long-term results were followed up with all patients during 1-5 years.

[Radioimmunologic analysis of ferritin, carcinoembryonic antigen and prolactin for evaluating the prognosis and effectiveness of treating breast cancer].

The levels of tumor markers--CEA, ferritin and prolactin (the hormone of the anterior pituitary gland) were studied in the blood serum of 178 breast cancer patients in the menopause during combined therapy using a radioimmunoassay. This combination was shown to be informative for assessment of prognosis of disease and efficacy of antitumor therapy which was confirmed by clinical and x-ray findings and observation of a tumor process in breast cancer patients over a 5-year period.

[Possibility of using tumor markers, pituitary gonadotropic hormones and prolactin in the diagnosis of breast cancer].

The levels of gonadotropic hormones, prolactin, carcinoembryonic antigen (CEA) and ferritin were measured in 111 females (52--cancer, 32--benign tumors and 27--healthy controls in menopause). Radioimmunologic study showed a significant increase in prolactin, CEA and ferritin levels in patients with T1-2N0M0 breast tumors.