Publications by authors named "Skipper N"

The ordering of ions and solvent molecules around nanostructures is of profound fundamental importance, from understanding biological processes to the manipulation of nanomaterials to optimizing electrochemical devices. Classical models commonly used to describe these systems treat the solvent simplistically, an approach that endures, in part, due to the extreme difficulty of attaining experimental measurements that challenge this approximation. Here we perform total neutron scattering experiments on model systems-concentrated amide solutions of negatively charged carbon nanotubes and sodium counterions-and measure remarkably complex intermediate-range molecular solvent ordering.

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Background: Brain disorders (neurological and mental disorders) are common and burdensome diseases. We examined occurrence, mortality, and economic burden of brain disorders in Denmark from 2015 to 2021.

Methods: We conducted a nationwide population-based cohort study using individual-level registry data.

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Background: Although acne is associated with scarring, mental health comorbidities and bullying, little is known about its impact on socio-economic outcomes.

Objectives: To examine the association between acne and educational, labour market and relationship outcomes.

Methods: We conducted a nationwide registry-based cohort study in Denmark.

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The complexity of variation in healthcare, particularly in mental health, remains poorly understood. However, addressing this issue presents an opportunity to opti-mise the allocation of scarce healthcare resources. To explore this, we investigated the variation in psychiatric care measured as the number of psychiatric hospitalisations.

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Childhood epilepsy has been linked to poor academic performance, but large-scale studies are lacking. In this nation-wide study of school-aged children, we examined the association between childhood epilepsy and school performance in standardized tests according to phenotypic and treatment-related characteristics. We performed a matched register-based cohort study of children born in Denmark (1997-2009) who participated in the Danish National School Test Programme between 2010 and 2019.

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Weak hydrogen bonds, such as O-H···π and C-H···O, are thought to direct biochemical assembly, molecular recognition, and chemical selectivity but are seldom observed in solution. We have used neutron diffraction combined with H/D isotopic substitution to obtain a detailed spatial and orientational picture of the structure of benzene-methanol mixtures. Our analysis reveals that methanol fully solvates and surrounds each benzene molecule.

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Background: Mental illness is common among refugees displaced by conflict and war. While evidence points to the relatively good health in terms of longevity of migrants resettled in the destination country, less is known about the mortality of the most vulnerable migrants with a trauma-related diagnosis alone and those with an additional comorbid psychotic disorder. This study aimed to provide an overview of the number and mortality of foreign-born individuals diagnosed with Post-Traumatic Stress Disorder or Enduring Personality Change after a Catastrophic Event (PTSD/EPCACE), a psychotic disorder or both.

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The structures of equimolar mixtures of the commonly used polar aprotic solvents dimethylformamide (DMF) and dimethylacetamide (DMAc) in dimethyl sulfoxide (DMSO) have been investigated via neutron diffraction augmented by extensive hydrogen/deuterium isotopic substitution. Detailed 3-dimensional structural models of these solutions have been derived from the neutron data via Empirical Potential Structure Refinement (EPSR). The intermolecular center-of-mass (CoM) distributions show that the first coordination shell of the amides comprises ∼13-14 neighbors, of which approximately half are DMSO.

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The Optic Neuritis Treatment Trial previously reported that corticosteroids accelerated visual recovery in optic neuritis (ON) without improving outcome. This finding related largely to multiple sclerosis (MS), and subsequently neurologists tended to await spontaneous recovery in ON. Since then, non-MS cases of ON have been identified with antibodies to aquaporin-4 (AQP4) or myelin oligodendrocyte glycoprotein (MOG).

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Background: Conflicting results have been reported concerning possible adverse effects on the cognitive function of offspring of mothers with type 1 diabetes (O-mT1D). Previous studies have included offspring of parents from the background population (O-BP), but not offspring of fathers with type 1 diabetes (O-fT1D) as the unexposed reference group.

Methods And Findings: This is a population-based retrospective cohort study from 2010 to 2016.

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Background: Preoperative anaemia is a risk factor for adverse postoperative outcomes after cardiac surgery. Iron deficiency is a frequent cause of low preoperative haemoglobin. An effective treatment for preoperative anaemia associated with iron deficiency has not been determined.

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We evaluate the consequences for patients of being matched to a new primary care provider due to practice closures. Using an event study and population-level data of patients and providers in Denmark, we find that the transition between providers is smooth; among re-matched patients, there is little change in primary care utilization at the extensive margin. Second, we document a 17% increase in fee-for-service per visit and a large increase in the probability that the patient initiates drug therapy targeting chronic and underdiagnosed diseases (hypertension, hyperlipidemia, and diabetes).

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Objective: Mean differences in HbA across centers are well established, but less well understood. The aim was to assess whether differences in patient case-mix can explain the variation in mean HbA between pediatric diabetes centers in Denmark. The association between HbA , frequency of blood glucose monitoring (BGM), treatment modality, and center visits was investigated.

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Background: Young refugees and descendants of refugees have different preconditions for learning than their peers without refugee background. Children growing up in families where parents have suffered torture and war trauma may represent a particularly vulnerable group. This study investigates whether children of torture survivors living in Denmark achieved different test scores throughout primary and secondary school compared to children of non-traumatized parents.

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Aims: The objective of the study was to compare grade point averages (GPAs) on compulsory school exit exams (exam GPA) and educational attainment at age 16 and 20 for individuals with and without type 1 diabetes.

Methods: This study was a population-based retrospective cohort study, which included the 1991 to 1998 birth cohorts in Denmark. Follow-up was conducted at age 16 and 20 (follow-up period; 1 January, 2007 to 31 December, 2018).

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The local and intermediate range ordering in Ca-NH solutions in their metallic phase is determined through H/D isotopically differenced neutron diffraction in combination with empirical potential structure refinements. For both low and high relative Ca concentrations, the Ca ions are found to be octahedrally coordinated by the NH solvent, and these hexammine units are spatially correlated out to lengthscales of ∼7.4-10.

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We leverage the onset of type 1 diabetes (T1D) in childhood to estimate the impact of a childhood health shock on parental labor supply. T1D is the second most common childhood chronic physical health condition, inheritability is low, the exact cause is unknown, the onset is unpredictable, and receiving treatment is crucial to survival. Using Danish administrative registry data with both an event study and difference-in-differences analysis shows that mothers shift to part-time work, marginally shift from the private to public sector, and experience a long-term 4-5% decrease in wage income.

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Objectives: To investigate whether negative media coverage of the human papillomavirus (HPV) vaccine led to a decrease in the uptake of the first dose of the HPV vaccine (HPV1) in Denmark and, importantly, whether some groups of individuals were more susceptible to negative media coverage.

Methods: We measured HPV vaccine uptake of 12-year-old girls born in 2001 to 2004 using Danish administrative data. A quasi-experimental design was employed to assess whether a documentary that was critical of the HPV vaccine and aired in March 2015 affected HPV uptake.

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Objectives: To examine the occurrence of brain disorders (ie, neurological and mental disorders) in Denmark and mortality and cost of illness among affected persons.

Design: Matched cohort study.

Setting: We obtained routinely collected registry data on all Danish residents during 1995-2015.

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Objective: To investigate school absenteeism before the clinical diagnosis of type 1 diabetes in children who develop the disease.

Research Design And Methods: This population-based, retrospective case-control study involved all Danish children who developed type 1 diabetes and attended public schools ( = 1,338) from 2010 to 2017. Those children were matched at a 1-to-5 ratio, on the basis of sex and date of birth, to children without diabetes ( = 6,690).

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Metal-organic framework (MOF)-related derivatives have generated significant interest in numerous energy conversion and storage applications, such as adsorption, catalysis, and batteries. However, such materials' real-world applicability is hindered because of scalability and reproducibility issues as they are produced by multistep postsynthesis modification of MOFs, often with high-temperature carbonization and/or calcination. In this process, MOFs act as self-sacrificial templates to develop functional materials at the expense of severe mass loss, and the resultant materials exhibit complex process-performance relationships.

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Aims/hypothesis: We aimed to examine the association of type 1 diabetes with school wellbeing among Danish children.

Methods: This is a population-based cohort study involving 436,439 Danish children, of which 1499 had a confirmed diagnosis of type 1 diabetes. The children were enrolled in grade levels 4 to 9 (middle school) in Danish public schools in the years 2014-2017.

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Objective: Evidence point to intergenerational effects of trauma in refugee populations. This study estimates the risk of psychiatric diagnoses in children of severely traumatized refugees. The unique clinical sample consisted of refugee parents treated for torture trauma and war trauma, and outcomes were investigated using population-level data.

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Metal-organic framework-derived carbon nanostructures have generated significant interest in electrochemical capacitors and oxygen/hydrogen catalysis reactions. However, they appear to show considerably varied structural properties, and thus exhibit complex electrochemical-activity relationships. Herein, a series of carbon polyhedrons of different sizes, between 50 nm and µm, are synthesized from zeolitic imidazolate frameworks, ZIF-8 (ZIF-derived carbon polyhedrons, ZDCPs) and their activity is studied for capacitance and the oxygen reduction reaction (ORR).

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