Publications by authors named "Skare T"
Background: Although there is clear evidence supporting the beneficial effects of regularly assessing patient-reported outcomes (PROs), the comprehensive integration of patient-reported outcome measures (PROMs) into routine cancer care remains limited. This study aimed to explore the facilitators and barriers encountered by principal investigators (PIs) (oncologists) and study nurses during the implementation of the Eir ePROM within a cluster randomized trial (c-RCT) in cancer outpatient clinics. Additionally, we sought to examine the influence of Eir on the working routines of the participants.
View Article and Find Full Text PDFBackground: Low vitamin D levels are commonly observed in autoimmune diseases, suggesting a potential role in disease pathogenesis. The presence of anti-vitamin D antibodies may contribute to these deficiencies and influence autoimmune processes.
Objective: To review and analyze studies investigating the occurrence of anti-vitamin D antibodies in autoimmune diseases.
Background: Inflammatory bowel diseases such as Crohn's disease and ulcerative colitis are influenced by environmental and immunological factors and may differ according to the patient's sex.
Objective: The objective was to study the differences in the clinical profile of a Brazilian sample of inflammatory bowel disease patients according to sex.
Methods: Retrospective study with chart review of 158 inflammatory bowel disease patients (43 with Crohn's disease and 115 with ulcerative colitis) from a single university hospital in southern Brazil.
Background: Dyslipidemia is described in several autoimmune conditions. Lipoprotein lipase (LPL) is responsible for triglyceride breakdown. Anti-LPL antibodies have been described.
View Article and Find Full Text PDFArticle Synopsis
- * A total of 29 studies involving 404 patients were analyzed, most focusing on diseases like systemic lupus erythematosus and multiple sclerosis, using a specific dosage and supportive treatments during therapy.
- * The treatment showed improvement in many patients, but some experienced side effects and relapses, indicating that while the approach can be effective, careful monitoring and support are crucial.
Article Synopsis
- Gastrointestinal intolerance is prevalent among rheumatoid arthritis patients using methotrexate, with 55.7% experiencing symptoms, primarily nausea and pain after taking the drug.
- The study identified factors associated with intolerance including afro-descendant background, existing fibromyalgia, and the use of glucocorticoids and Jak inhibitors.
- Logistic regression revealed that using glucocorticoids significantly increased the likelihood of methotrexate intolerance, while adherence to methotrexate was generally moderate.
Background: Routine screening for viral infections at blood donation is important to avoid transfusion-transmitted infections. It also offers an opportunity to detect an asymptomatic infection.
Objective: To study changes in serology positivity for viral infections (B and C hepatitis, HTLV-1/2, and HIV) at blood donation in a blood bank from Southern Brazil, comparing two periods of 5 years: the period from 2013 to 2017 with the period from 2018 to 2022.
Article Synopsis
- Chronic Fatigue Syndrome (CFS), Fibromyalgia (FM), and related conditions, including Long-COVID and others, share symptoms like fatigue, pain, and cognitive issues, often influenced by autonomic dysfunction and immune responses.
- The study reviews literature from January 1990 to January 2024, analyzing 172 articles focused on hearing issues, such as tinnitus and vertigo, associated with these conditions.
- Symptoms related to hearing disturbances are highly variable, with cochlear problems being the most common, while mechanisms like autoimmune reactions and virus effects on the nervous system are proposed as potential causes.
Cannabis has been used in rheumatic diseases as therapy for chronic pain or inflammatory conditions. Herein, the authors systematically review the rheumatological diseases in which cannabis has been studied: systemic sclerosis, fibromyalgia, osteoarthritis, rheumatoid arthritis, osteoporosis, polymyalgia rheumatica, gout, dermatomyositis, and psoriatic arthritis. We systematically searched PubMed for articles on cannabis and rheumatic diseases between 1966 and March 2023.
View Article and Find Full Text PDFIntroduction: Patients with fibromyalgia (FM) have innumerable complaints due to the central amplification of somatic stimuli. The aim of this paper was to review the ear complaints in patients with FM.
Methods: A review of articles published in PubMed/MEDLINE, Embase, Web of Science, and Scopus from 1966 to June 2023 was performed.
Background: Low bone mass density (BMD) is an extraintestinal finding in celiac disease (CD). This may result in bone fractures leading to loss in quality of life.
Objective: To assess BMD in male CD patients at diagnosis according to the patient's age.
Objective: The aim of the study was to compare the epidemiology and clinical profiles of hospital admissions in a single Brazilian Hepatology Unit from the period 2014-2017 to 2019-2022.
Methods: A retrospective analysis of hospital database from the abovementioned periods was done. The study included patients over the age of 18 years who were hospitalized due to complications of diseases such as viral hepatitis, alcoholic disease, nonalcoholic fatty liver disease, and autoimmune liver and drug-induced hepatitis.
To be or not to B27 positive: implications for the phenotypes of axial spondyloarthritis outcomes. Data from a large multiracial cohort from the Brazilian Registry of Spondyloarthritis.
Adv Rheumatol
April 2024
Background: There is a remarkable variability in the frequency of HLA-B27 positivity in patients with spondyloarthritis (SpA), which may be associated with different clinical presentations worldwide. However, there is a lack of data considering ethnicity and sex on the evaluation of the main clinical and prognostic outcomes in mixed-race populations. The aim of this study was to evaluate the frequency of HLA-B27 and its correlation with disease parameters in a large population of patients from the Brazilian Registry of Spondyloarthritis (RBE).
View Article and Find Full Text PDFBackground: Nail involvement is frequent in patients with psoriasis (Pso) and psoriatic arthritis (PsA) and there is a relationship between nail involvement and inflammation of the enthesis. The main objective of the present study is to describe the ultrasound findings and clinical characteristics of nails from patients with psoriasis and psoriatic arthritis with and without nail dystrophy.
Methods: A cross-sectional study including consecutive patients with PsO and PsA was carried out.
Background: Antineutrophil cytoplasmatic antibodies (ANCA) have been detected in patients with systemic lupus erythematosus (SLE). In this study, we investigated the presence of ANCA in a sample of Brazilian SLE patients and its possible associations with clinical and serological outcomes. Additionally, we reviewed the literature of on ANCA in SLE.
View Article and Find Full Text PDFObjective: Patients with rheumatic diseases have an increased risk of infections, especially tuberculosis. In this study, we aimed to recognize the positivity rate of tuberculosis skin test in patients with rheumatoid arthritis and spondyloarthritis and the characteristics of the patients with positive results.
Methods: Retrospective study of tuberculosis skin test results in patients followed from 2004 to 2021 in a single rheumatology unit.
Coenzyme Q10 supplementation in rheumatic diseases: A systematic review.
Clin Nutr ESPEN
February 2024
Coenzyme Q10 (CoQ10) is a potent antioxidant and anti-inflammatory substance used to treat some rheumatic diseases. Our objective was to review the use of CoQ10 in rheumatic diseases. PubMed/Medline, Embase, Scopus, and Web of Science databases were searched for articles on CoQ10 and rheumatic diseases between 1966 and April 2023.
View Article and Find Full Text PDFObjectives: This study aimed to evaluate the clinical and serological profile in systemic sclerosis (SSc) by comparing females and males.
Patients And Methods: This retrospective study was conducted with 215 SSc patients (193 females, 22 males; mean age: 50.1±14.
Dehydroepiandrosterone (DHEA) Supplementation in Rheumatic Diseases: A Systematic Review.
Mediterr J Rheumatol
September 2023
Background: Dehydroepiandrosterone (DHEA) is an adrenal hormone used to treat rheumatic conditions such as systemic lupus erythematosus (SLE), Sjogren's syndrome (SS), rheumatoid arthritis (RA) with controversial results.
Aim: To review the results of DHEA use in rheumatic diseases.
Methods: PubMed, Scielo, Scopus, and Embase databases were systematically searched for articles on the treatment of rheumatic diseases with DHEA between 1966 and April 2023.
Objective: To compare clinical and laboratory data obtained from patients with primary Antiphospholipid Syndrome (PAPS) with and without limb ischemia (LI).
Methods: A transverse study with 66 (83.3% female) PAPS patients was performed.
Objective: Inflammatory bowel diseases may have extra intestinal manifestations such as those affecting the skin. This study aimed to study skin manifestations in a cohort of Brazilian patients with inflammatory bowel diseases.
Methods: Epidemiological and clinical data were obtained through a cross-sectional study of 70 inflammatory bowel diseases patients and a control group comprising 50 healthy individuals.
Background: Obesity has been linked to the development and progression of autoimmune diseases.
Aim: To investigate the presence of autoantibodies in the sera of bariatric-surgery patients.
Methods: During the pre- and postoperative period, sera from 79 patients undergoing bariatric surgery were tested for the presence of antinuclear antibodies (ANA), Rheumatoid Factor (RF), IgG and IgM anticardiolipin antibodies, and anti-endomysial antibodies.