Integrating Network Pharmacology and In Silico Analysis to Explore the Bioactive Compounds Against Gastric Cancer Treatment.

Gastric cancer (GC) has become a major challenge in oncology research, primarily due to its detection at advanced stages. In this study, we identified and validated the pharmacological mechanisms involved in treating gastric cancer using an integrated approach combining network pharmacology, molecular docking, and a dynamic approach. Gastric cancer-related genes were obtained from DisGeNET, Genecard, and Malacard databases, while potential targets of bioactive compounds were predicted using SwissTargetPrediction.

Raman signatures of inversion symmetry breaking structural transition in quasi-1D compound, (TaSe4)3I.

The breaking of inversion symmetry combined with spin-orbit coupling, can give rise to intrigu- ing quantum phases and collective excitations. Here, we report systematic temperature dependent Raman scattering and theoretical calculations of phonon modes across the inversion symmetry- breaking structural transitions in a quasi-one-dimensional compound (TaSe4)3I. Our investigation revealed the emergence of three additional Raman-active modes in Raman spectra of the low- temperature (LT) non-centrosymmetric (NC) structure of the material.

MOF-Derived Hollow C, N-Doped CoO Dodecahedral Nanostructure Enwrapped with MgInS Nanosheets for Enhanced Photocatalytic N Reduction.

Design of hierarchical hollow nanoheterostructure materials through interfacial and defect engineering is an innovative approach for achieving optimal charge separation dynamics and photon harvesting efficiency. Herein, we have described a facile technique to fabricate hollow MOF-derived C, N-doped-CoO (C, N-CoO) dodecahedral particles enwrapped with MgInS nanosheets for enhanced N reduction performance. ZIF-67 was initially used as a sacrificial template to prepare hollow C, N-CoO using a carbonization route followed by low-temperature calcination treatment.

Seroprevalence of Measles Antibodies Among Migrant Populations: A Systematic Review and Meta-Analysis.

Incomplete or interrupted vaccination schedules put migrant communities at higher risk for measles, which remains a serious public health concern. The objective of this systematic review was to evaluate the pooled seroprevalence of measles antibodies among migrant groups globally and offer data to guide public health initiatives. Our literature search included PubMed, Scopus, and Embase databases, covering publications from 1990 to 2023, and was systematically refined using specific inclusion and exclusion criteria.

Field emission performance of graphene-incorporated aluminum-based metal matrix composite.

The 'close proximity' configuration was used for field emission analysis of graphene-incorporated aluminum (Al) composites. The turn-on field was found to be 2 V μm for the AlGr1 (1% graphene (by weight) inside the Al matrix) composite compared to 4.75 V μm for the pristine aluminum sample.

Comparative metabolomics-based screening of fruit extracts of less-known melon ( var accessions collected from dry terrain of North India by using HPLC-DAD.

(Naudin) is an important wild crop that belongs to the family Cucurbitaceae. Fruits possess digestive, stomachic, vermifuge and febrifuge properties and possess analgesic, antioxidant, antibacterial and anti-inflammatory activities. Current research is aimed at screening diverse phytoconstituents present in the fruit extract of wild melon ( var.

Traditional Chinese Medicine and Headache Disorders-A Review of Categorization and Selected Therapeutic Approaches.

Headaches have emerged as a prevailing global health concern, impacting millions of individuals and posing challenges to public health care systems. With an escalating number of patients seeking complementary therapies to attain a more holistic approach for headaches, Traditional Chinese Medicine has gained significant popularity. It plays a pivotal role in advancing the safeguarding of health and the alleviation of prevalent, recurrent, and complex medical conditions.

Comparative HPTLC analysis of shatavarin IV, sarsasapogenin, caffeic acid, β-sitosterol and lupeol in roots and cladodes of ten L. ssp. from North India.

In the present research, ten species of from North India have been analysed for secondary metabolites. The quantitative study of shatavarin IV, sarsasapogenin, caffeic acid, β-sitosterol, and lupeol in the cladodes and roots of Asparagus was conducted using a validated HPTLC method. The content of sarsasapogenin was found highest in the cladodes of (11.

AScirRNA: A novel computational approach to discover abiotic stress-responsive circular RNAs in plant genome.

In the realm of plant biology, understanding the intricate regulatory mechanisms governing stress responses stands as a pivotal pursuit. Circular RNAs (circRNAs), emerging as critical players in gene regulation, have garnered attention in recent days for their potential roles in abiotic stress adaptation. A comprehensive grasp of circRNAs' functions in stress response offers avenues for breeders to manipulating plants to develop abiotic stress resistant crop cultivars to thrive in challenging climates.

Prevalence and Predictors of Domestic Violence in India: Complex Sample Analysis of a Nationally Representative Study Conducted Between 2019 and 2021.

Background:  Violence against women has been one of the dreaded social evils that humanity is facing. There have been concerted efforts to eliminate this evil, and sustainable development goals goal 5.2.

Histone variant macroH2A1 regulates synchronous firing of replication origins in the inactive X chromosome.

MacroH2A has been linked to transcriptional silencing, cell identity, and is a hallmark of the inactive X chromosome (Xi). However, it remains unclear whether macroH2A plays a role in DNA replication. Using knockdown/knockout cells for each macroH2A isoform, we show that macroH2A-containing nucleosomes slow down replication progression rate in the Xi reflecting the higher nucleosome stability.

Long-Lasting Insecticidal Net Coverage and Utilization in Burla Town of Sambalpur District: A Cross-Sectional Study.

Background Vector-borne diseases continue to significantly contribute to mortality and morbidity, especially in developing nations. Vector management is a key pillar in combating these diseases, and long-lasting insecticidal nets (LLINs) are cost-effective tools. The Government of India, under the National Vector Borne Disease Control Programme (NVBDCP), has distributed LLINs for free to increase coverage and utilization.

Structural and electronic transport properties of Zn- and Ga-doped BiSbTeSetopological insulator single crystals.

A comprehensive study of structural and magnetotransport properties of pristine BiSbTeSe(BSTS) single crystals and doped with Zn (BSTS:Zn) and Ga (BSTS:Ga) are presented here. Magnetic field dependent Hall resistivities of the single crystals indicate that the holes are the majority carriers. The field dependent resistivity curves at different temperatures of the crystals display cusp-like characteristics at low magnetic fields, attributed to two-dimensional (2D) weak antilocalization (WAL) effect.

Daith piercing: Revisited from the perspective of auricular acupuncture systems. A narrative review.

Background: Daith piercing is a special ear-piercing method that punctures the crus of the helix. The penetrated site at the ear's innermost point is assumed to stimulate a pressure point associated with the vagus nerve. It has been reported that the pierced spot relieves migraine and tension-type headaches by activating vagal afferents, leading to the inhibition of neurons in the caudal trigeminal nucleus via the nucleus tractus solitarii.

SpeedFlower: a comprehensive speed breeding protocol for indica and japonica rice.

To increase rice yields and feed billions of people, it is essential to enhance genetic gains. However, the development of new varieties is hindered by longer generation times and seasonal constraints. To address these limitations, a speed breeding facility has been established and a robust speed breeding protocol, SpeedFlower is developed that allows growing 4-5 generations of indica and/or japonica rice in a year.

Immunogenicity of ChAdOx1 (Covishield) Booster Dose in Healthcare Providers: A Pre-Post Study.

Background Worldwide, healthcare workers who face a higher risk of contracting coronavirus disease 2019 (COVID-19) were among the first to receive COVID-19 vaccinations. Following the initial two vaccine doses, health experts recommended a third booster shot to enhance protection against the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) virus. However, limited information about how this booster dose affects antibody levels is available.

CRISPR/Cas9 mediated editing of () gene disrupts mating in the Fall armyworm, (J. E. Smith) (Lepidoptera: Noctuidae).

Unlabelled: The Fall armyworm, , is a globally important invasive pest, primarily on corn, causing severe yield loss. Overuse of synthetic chemicals has caused significant ecological harm, and in many instances control has failed. Therefore, developing efficient, environmentally friendly substitutes for sustainable management of this pest is of high priority.

Assessment of Medication Adherence and Associated Factors Among Patients With Diabetes Attending a Non-communicable Disease Clinic in a Community Health Centre in Eastern India.

Background Non-adherence to medication represents a modifiable risk factor for patients with type 2 diabetes mellitus (T2DM). Identification of patients with poor adherence can have a significant impact on clinical and socio-economic outcomes in the management of diabetes. This study aimed to assess medication adherence and its associated factors among patients with T2DM attending a non-communicable disease (NCD) clinic in a rural community health centre (CHC) in eastern India.

Risk Factors of Pre-eclampsia: A Hospital-Based Case-Control Study.

Introduction Pre-eclampsia is a pregnancy-specific hypertensive disorder and is one of the leading causes of maternal and infant morbidity and mortality in India and worldwide. Evidence of the association between various risk factors and pre-eclampsia is scarce in developing countries. As pre-eclampsia remains a leading cause of maternal mortality and morbidity, focusing on the causes and risk factors of pre-eclampsia during antenatal surveillance would prevent maternal deaths and reduce the maternal mortality rate.

Risk factors and outcome of acute kidney injury in children with snake envenomation.

Our study evaluates the risk factors of acute kidney injury (AKI) in children with snake envenomation. Out of 145 cases, 54 (37%) developed AKI. Unsurprisingly, the mortality increased with oliguria and higher levels of creatinine.