An Emission-Based Probe for the Detection and Quantification of DNA and RNA.

Sequence-independent detection of low concentrations of nucleic acids is important for applications in forensics and diagnostics. An emission-based probe for detecting and quantifying DNA and RNA utilizing a water-soluble dicationic tetraphenylethene (TPE) derivativewas developed. The recognition is based on the electrostatic and other non-covalent interactions between the phosphate backbone of nucleic acids and the cationic probe, which cause the restriction of rotation of the aryl units of the probe, ensuing in the enhancement of the fluorescence signal.

Light-Gated Modulation of Electronic Mobility of a Dihydropyrene-Based Photochromic Coordination Polymer.

Photo-induced modulation of electronic conductance has been achieved by employing an Ag-based two-dimensional coordination polymer (CP) having pyridine-functionalized photochromic dimethyldihydropyrene-cyclophanediene (DHP-CPD) π-switch. Both the coordination polymer and the organic photochromic core were characterized by single-crystal X-ray diffraction studies. The coordination polymer displayed an excellent conductance in the ON state of the switch in the closed form of DHP.

Switching the recognition ability of a photoswitchable receptor towards phosphorylated anions.

An azobenzene based photoswitchable macrocyclic receptor displays different binding affinities in its E and Z forms towards various phosphorylated coenzymes under physiological conditions with remarkable selectivity for ATP in the E-form and selectivity towards GTP in the photoisomerized Z-form. Linear discriminant analysis clearly separated the analytes using the E-form. An application of this method enabled monitoring the progress of enzymatic phosphorylation using a tyrosine kinase enzyme.

Light triggered encapsulation and release of C with a photoswitchable TPE-based supramolecular tweezers.

Stimuli responsive hosts for C can control its binding and release on demand. A photoswitchable TPE based supramolecular host can encapsulate C in the Z-form with a markedly different visual change in the colour. In addition, the Z-1 bound C has been characterized by various spectroscopic methods and mass spectrometry.

A phototunable anion receptor for C-HX interactions with benzoate anions.

A supramolecular receptor consisting of two anthracene moieties with binding motifs for binding of benzoate anions is reported here. NMR studies indicate that the binding involves π-π interactions and CHX interactions. Upon exposure to >350 nm light, the receptor undergoes a [4 + 4] photoelectrocyclization restricting the access to the binding site for benzoate.

Formation of disulphide linkages restricts intramolecular motions of a fluorophore: detection of molecular oxygen in food packaging.

Reliable and easy detection of oxygen in food packaging without the aid of sophisticated instruments is highly coveted. A tetraphenylethene probe based on oxygen-mediated polymerization via the formation of disulfides causes restricted intramolecular rotation of the TPE phenyls resulting in a >100 fold enhancement of emission and thus detects O2 in food packages.

A Minimalist Approach for Distinguishing Individual Lanthanide Ions Using Multivariate Pattern Analysis.

To discriminate among the 14 trivalent lanthanide ions, curcumin, a naturally occurring, nontoxic, off-the-shelf, commercially available compound containing a single fluorophore, was chosen as a probe in the water media at pH 6.8 and pH 8.2.

A Kamikaze Approach for Capturing Hg(2+) Ions through the Formation of a One-Dimensional Metal-Organometallic Polymer.

Efficient uptake of Hg(2+) ions in mercury-resistant bacteria is attributed to the presence of cysteine thiolates in the Mer proteins. In this work, a pyridine-appended pyridine-fused imidazolyl-2-thione scaffold was used as a mimic for the cysteinyl residues for efficient binding of the Hg(2+) ions. In the presence of Hg(2+) ions, an aryl C-H bond of the ligand is activated.