Metabolism and Excretion of Intravenous, Radio-Labeled Amisulpride in Healthy, Adult Volunteers.

Purpose: Intravenous amisulpride, a dopamine D/D antagonist, has recently been shown in trials to be an effective antiemetic at low doses. This study was conducted to investigate the metabolism and elimination of a single dose of intravenous C-labeled amisulpride in healthy, adult volunteers.

Patients And Methods: Six healthy male volunteers aged 18-65 years were given a single 10 mg dose of C-labeled amisulpride containing not more than 1.

Pharmacokinetics of [14C]ciclesonide after oral and intravenous administration to healthy subjects.

Background: Ciclesonide is a novel inhaled corticosteroid developed for the treatment of asthma.

Objective: To investigate the extent of oral absorption and bioavailability of ciclesonide referenced to an intravenous infusion. This information provides an estimate for the contribution of the swallowed fraction to systemic exposure to ciclesonide after oral inhalation.