Publications by authors named "Sizheng Guo"
Article Synopsis
- The B7-H1/PD-1 immune pathway is bi-directional, meaning it can inhibit or promote immune responses depending on the context.
- Previous research found that B7-H1 can act as an anti-apoptotic receptor, helping cells survive when engaged by PD-1.
- In mouse models of graft-versus-host disease (GVHD), manipulating this pathway either accelerated disease progression with wild-type T-cells or improved symptoms and tolerance with PD-1 deficient T-cells, highlighting its complex role in immune responses.
The role of B7-DC in T-cell responses remains controversial because both coinhibitory and costimulatory functions have been reported in various experimental systems in vitro and in vivo. In addition to interacting with the coinhibitory receptor PD-1, B7-DC has also been shown to bind repulsive guidance molecule b (RGMb). The functional consequences of the B7-DC/RGMb interaction, however, remain unclear.
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