Publications by authors named "Sizhen Lai"
Article Synopsis
- NAFLD is a common liver disease that can cause serious health problems, so it's important to find ways to diagnose it early.
- Researchers used special computer methods to find out which genes can help in diagnosing NAFLD, focusing on four specific genes: FOSB, GPAT3, RGCC, and RNF43.
- The study showed that these four genes are very good at identifying NAFLD in both human blood samples and liver samples from mice.
: Garlic has antioxidant, anti-inflammatory, cardiovascular improvement and other beneficial effects on human health. However, few studies have evaluated the association of garlic intake with the risk of depressive symptoms. The aim of this prospective cohort was to examine the association between the frequency of raw garlic consumption and depressive symptoms in the general adult population.
View Article and Find Full Text PDFMetabolic reprogramming is a hallmark of cancer, including lung cancer. However, the exact underlying mechanism and therapeutic potential are largely unknown. Here we report that protein arginine methyltransferase 6 (PRMT6) is highly expressed in lung cancer and is required for cell metabolism, tumorigenicity, and cisplatin response of lung cancer.
View Article and Find Full Text PDFYoung Patients With Colorectal Cancer Have Higher Early Mortality but Better Long-Term Survival.
Clin Transl Gastroenterol
December 2022
Introduction: To define the prognosis of colorectal cancer (CRC) in young patients and to compare their postoperative treatment with that of older patients.
Methods: This multicenter study enrolled 5,457 patients with primary CRC who underwent surgical resection. The overall survival (OS), clinicopathologic characteristics, and postoperative treatment of 253 young patients aged 18-44 years and 5,204 older patients aged 44-80 years were analyzed.
Background: Previous studies have reported the prognostic value of p53 upregulated modulator of apoptosis (PUMA) in numerous human tumors, but the conclusions have not been consistent. Therefore, this meta-analysis and the Cancer Genome Atlas (TCGA) data analysis were performed to estimate the prognostic significance of PUMA in solid tumors.
Research Design And Methods: A search was conducted in PubMed, Embase, Web of Science, Cochrane Library and CNKI up to 21 July 2022.
Connexin 43 contributes to the sensitization of colorectal cancer cells to photodynamic therapy through Akt inhibition.
Photodiagnosis Photodyn Ther
September 2022
Background: Photodynamic therapy could be one approach to treat colorectal cancer though resistance leads to failure of therapy. Akt activation is a cellular survival response to photodynamic therapy and is also a reason for resistance. Thus, inhibition of Akt is a strategy to decrease resistance.
View Article and Find Full Text PDFArticle Synopsis
- SIRT6 is a member of the sirtuin family and plays various roles, including influencing immune response and cancer progression, which this study aimed to explore by linking SIRT6 expression to patient outcomes in solid tumors.
- A meta-analysis was performed using data from PubMed and ISI Web of Science, focusing on the relationship between SIRT6 levels and clinicopathological features, ultimately leading to findings published in Cancer Research.
- The study revealed that lower SIRT6 expression correlated with better overall and disease-free survival in patients with solid tumors, although its impact varied between cancer types, showing benefits in breast cancer but worse outcomes in gastrointestinal cancers.