Publications by authors named "Siyun Zhou"

Topological phases are robust against weak perturbations, but break down when disorder becomes sufficiently strong. However, moderate disorder can also induce topologically nontrivial phases. Thouless pumping, as a (1+1)D counterpart of the integer quantum Hall effect, is one of the simplest manifestations of topology.

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Silicosis is a fatal occupational pulmonary disease that is characterized by irreversible replacement of lung parenchyma by aberrant Exracellular matrix (ECM). Metabolic reprogramming is a crucial mechanism for fibrosis. However, how the metabolic rewiring shifts the ECM homeostasis toward overaccumulation remains unclear.

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Article Synopsis
  • High-order topological phases involve systems with unique multi-dimensional properties, showing localized states on lower-dimensional boundaries and can be used in topological pumping experiments.
  • The research demonstrates the creation of corner-localized states on a lattice of superconducting qubits using a process that modifies quantum interactions adiabatically.
  • The team also examines how these topological pumps handle different types of disorder, providing insights into their stability and encouraging further exploration of high-order topological phases in quantum systems.
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This study aims to identify colorectal cancer (CRC)-related proteomic profiles and develop a prediction model for CRC onset by integrating proteomic profiles with genetic and non-genetic factors (QCancer-15) to improve the risk stratification and estimate of personalized initial screening age. Here, using a two-stage strategy, we prioritize 15 protein biomarkers as predictors to construct a protein risk score (ProS). The risk prediction model integrating proteomic profiles with polygenic risk score (PRS) and QCancer-15 risk score (QCancer-S) shows improved performance (C-statistic: 0.

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Background: Allostatic load (AL) reflects the cumulative burden of chronic stress throughout life, potentially influencing the onset and prognosis of cancer. However, the associations between AL, colorectal cancer (CRC) risk, and all-cause mortality in patients with CRC remain unclear.

Methods: We analyzed the associations between AL and CRC risk in 304 959 adults and all-cause mortality in 1794 patients with CRC from the UK Biobank, using Cox proportional hazards regression models.

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Background: Elevated allostatic load (AL) has been associated with the risk and poor prognosis of many chronic diseases. The association between AL and inflammatory bowel disease (IBD) is unknown.

Aims: The aim of this study is to investigate the associations between AL and the risk and prognosis of IBD.

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  • Metabolic dysfunction-associated fatty liver disease (MAFLD) is a major health concern, and dietary interventions can significantly impact patients' outcomes.
  • A study involving 175,300 patients demonstrated that specific diets, like the alternate Mediterranean diet and plant-based diets, are linked to a lower risk of chronic liver disease and related complications.
  • In contrast, unhealthy plant-based diets were associated with increased risks of liver disease, emphasizing the importance of dietary choices for those with MAFLD.
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  • Large studies are needed to understand how physical activity, sedentary behaviors, and sleep affect cancer risk, considering genetic factors.
  • A study with 360,271 participants found that higher levels of physical activity and better sleep reduced cancer risk, while more sedentary behavior increased it.
  • Those with low physical activity and poor sleep had the highest risk for various cancers, indicating that improving sleep and exercise could help lower cancer risk, regardless of genetics.
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Recovering valuable active substances from the by-products of agricultural processing is a crucial concern for scientific researchers. This paper focuses on the enrichment of soybean trypsin inhibitor (STI) from soybean whey wastewater using either ammonium sulfate salting or ethanol precipitation, and discusses their physicochemical properties. The results show that at a 60% ethanol content, the yield of STI was 3.

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  • - The study focused on identifying plasma and urinary metabolites linked to colorectal cancer (CRC) risk and understanding how these metabolites mediate the effects of modifiable risk factors on CRC.
  • - Researchers analyzed data from large-scale studies, identifying 30 plasma and 4 urinary metabolites associated with CRC and noting that certain metabolites could be targeted by drugs for intervention.
  • - Findings highlighted 13 modifiable risk factors influencing CRC through 9 identified metabolites, shedding light on potential therapeutic targets and the relationships between lifestyle factors and colorectal cancer development.
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  • * Results from a 12.97-year follow-up of 428,632 participants showed that higher APES scores correlated with increased CRC incidence and worse survival rates, especially among inactive individuals and smokers.
  • * The meta-analysis confirmed that exposure to particulate matter (PM) is linked to a higher CRC risk, and specific genetically predicted DNA methylations related to air pollution were also associated with increased cancer risk, indicating significant gene-environment interactions.
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Epithelial-mesenchymal transition (EMT) is a vital pathological feature of silica-induced pulmonary fibrosis. However, whether circRNA is involved in the process remains unclear. The present study aimed to investigate the role of in the silica-induced EMT and the underlying mechanisms.

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Purpose: Patients are typically diagnosed with both hypertension and fibrosarcoma. Medical oncologists must prescribe suitable anti-hypertensive medications while considering anti-tumor drugs. Recently, immunotherapy has become prominent in cancer treatment.

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As a fatal occupational disease with limited therapeutic options, molecular mechanisms underpinning silicosis are still undefined. Herein, single-cell RNA sequencing of the lung tissue of silicosis mice identified two monocyte subsets, which were characterized by Cxcl10 and Mmp14 and enriched in fibrotic mouse lungs. Both Cxcl10 and Mmp14 monocyte subsets exhibited activation of inflammatory marker genes and positive regulation of cytokine production.

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Background: Pulmonary fibrosis is a growing clinical problem that develops as a result of abnormal wound healing, leading to breathlessness, pulmonary dysfunction and ultimately death. However, therapeutic options for pulmonary fibrosis are limited because the underlying pathogenesis remains incompletely understood. Circular RNAs, as key regulators in various diseases, remain poorly understood in pulmonary fibrosis induced by silica.

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Background: The proteome is an important reservoir of potential therapeutic targets for cancer. This study aimed to examine the causal associations between plasma proteins and cancer risk and to identify proteins with cross-cancer effects.

Methods: Genetic instruments for 3991 plasma proteins were extracted from a large-scale proteomic study.

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Silicosis is a global occupational pulmonary disease due to the accumulation of silica dust in the lung. Lacking effective clinical drugs makes the treatment of this disease quite challenging in clinics largely because the pathogenic mechanisms remain obscure. Interleukin 33 (IL33), a pleiotropic cytokine, could promote wound healing and tissue repair via the receptor ST2.

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Pulmonary fibrosis (PF), as an end-stage clinical phenotype of interstitial lung diseases (ILDs), is frequently initiated after alveolar injury, in which ferroptosis has been identified as a critical event aggravating the pathophysiological progression of this disease. Here in, a comprehensive analysis of two mouse models of pulmonary fibrosis developed in our lab demonstrated that lung damage-induced ferroptosis of alveolar epithelial Type2 cells (AEC2) significantly accumulates during the development of pulmonary fibrosis while ferroptosis suppressor genes GPX4 and FSP1 are dramatically inactivated. Mechanistically, upregulation of de novo methylation regulator Uhrf1 sensitively elevates CpG site methylation levels in promoters of both GPX4 and FSP1 genes and induces the epigenetic repression of both genes, subsequently leading to ferroptosis in chemically interfered AEC2 cells.

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Long-term inhalation of welding fume at high exposure can cause welder's pneumoconiosis, and metals in welding dust are associated with respiratory dysfunction. This cross-sectional study, which contains 384 Chinese male workers who were or had been working in a container factory, aimed to assess the potential risk of haemal and urinary metal content in welder's pneumoconiosis. Further, we investigated their effects on lung function parameters.

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Objective: The objective of this study was to compare the efficacy differences between Chinese patent medicines combined with hormone replacement therapy (HRT) in the treatment of premature ovarian failure (POF) by the Bayesian network meta-analysis (NMA) method.

Methods: Randomized controlled trials (RCTs) reporting Chinese patent medicine combined with HRT for POF included Medline ( PubMed), Embase, Cochrane Library, China National Knowledge Infrastructure Database (CNKI), Wanfang Database (Wanfang), VIP Database (VIP), and China Biology Medicine Database (CBM) from the inception of the databases to July 2022. Two researchers independently screened the articles, extracted data, and evaluated the quality.

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Background: Pulmonary fibrosis is a chronic progressive fibrotic interstitial lung disease characterized by excessive extracellular matrix (ECM) deposition caused by activated fibroblasts. Increasing evidence shows that matrix stiffness is essential in promoting fibroblast activation and profibrotic changes. Here, we investigated the expression and function of matrix stiffness-regulated ZNF416 in pulmonary fibrotic lung fibroblasts.

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Pulmonary fibrosis is a chronic and progressive interstitial lung disease associated with the decay of pulmonary function, which leads to a fatal outcome. As an essential epigenetic regulator of DNA methylation, the involvement of ubiquitin-like containing PHD and RING finger domains 1 (UHRF1) in fibroblast activation remains largely undefined in pulmonary fibrosis. In the present study, we found that TGF-β1-mediated upregulation of UHRF1 repressed beclin 1 via methylated induction of its promoter, which finally resulted in fibroblast activation and lung fibrosis both in vitro and in vivo.

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Objective: To understand the related risk factors of occurrence and recurrence of hypertension and provide scientific basis for relevant departments to better guide prevention and control work.

Methods: From September 2017 to September 2018, a prospective follow-up study was performed on patients with hypertension who visited the Second People's Hospital of Wuhu City, Anhui Province. Multivariate Cox regression was used to analyze influencing factors of stroke occurrence and recurrence in follow-up of hypertensive patients.

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Exposure to silica is a cause of pulmonary fibrosis disease termed silicosis, which leads to respiratory failure and ultimately death. However, what drives fibrosis is not fully elucidated and therapeutic options remain limited. Our previous RNA-sequencing analysis showed that the expression of caveolin-1 (CAV1) was downregulated in silica-inhaled mouse lung tissues.

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