Publications by authors named "Siyun L Wang"
Cancers (Basel)
August 2024
Article Synopsis
- ARID1A, a key part of the BAF chromatin remodeling complex and mutated in about 8% of cancers, shows highest mutation rates in clear cell ovarian carcinoma (CCOC), reaching over 50%.
- Current treatments for ARID1A-deficient cancers are limited, prompting research into genetic dependencies using CRISPR screening.
- The study identifies KEAP1 as a critical factor in ARID1A-deficient cells, where targeting KEAP1 leads to selective growth inhibition and worsens genome instability, highlighting a potential new therapeutic approach.
