Apple Polyphenol Extracts Attenuated Depressive-Like Behaviors of High-Sucrose Diet Feeding Mice by Farnesoid X Receptor-Mediated Modulation of Bile Acid Circulation within the Liver-Gut-Brain Axis.

Although the association between high-sugar diets and depression has been verified, few studies have explored the antidepressant mechanisms of apple polyphenol extracts (APE). Therefore, fifty-four C57BL/6 male mice aged 5 weeks were randomly assigned into five groups: the control group with the standard diet (CON), the constant high-sucrose diet group (HSD), the "2 + 5" alternate diet group (A-HSD), and the 500 mg/(kg·bw) APE treatment for the HSD group (APE) and the A-HSD group (A-APE), respectively. The data of hypothalamic-pituitary-adrenal (HPA) axis function and behavioral experiments confirmed the success in the establishment of depression-like mouse models in both HSD and A-HSD groups, which were significantly alleviated after APE treatment.

Biomimetic Mineralized 3D-Printed Polycaprolactone Scaffold Induced by Self-Adaptive Nanotopology to Accelerate Bone Regeneration.

Three-dimensional (3D)-printed biodegradable polymer scaffolds are at the forefront of personalized constructs for bone tissue engineering. However, it remains challenging to create a biological microenvironment for bone growth. Herein, we developed a novel yet feasible approach to facilitate biomimetic mineralization via self-adaptive nanotopography, which overcomes difficulties in the surface biofunctionalization of 3D-printed polycaprolactone (PCL) scaffolds.

Apple polyphenol extract ameliorates sugary-diet-induced depression-like behaviors in male C57BL/6 mice by inhibiting the inflammation of the gut-brain axis.

To explore whether apple polyphenol extract (APE) ameliorates sugary-diet-induced depression-like behaviors, thirty male C57BL/6 mice (3-4 weeks old) were assigned to three groups randomly to receive different treatments for 8 consecutive weeks: (1) control group (CON), (2) S-HSD group (60% high sucrose diet feeding with 0.1 mg mL sucralose solution as drinking water), and (3) S-APE group (S-HSD feeding with 500 mg per (kg bw day) APE solution gavage). The S-HSD group showed significant depression-like behaviors compared with the CON group, which was manifested by an increased number of buried marbles in the marble burying test, prolonged immobility time in both the tail suspension test and forced swimming test, and cognitive impairment based on the Morris water maze test.

Other-Benefiting Lying Behavior in Preschool Children and Its Relation to Theory of Mind and Empathy.

The present study examined children's lies to help others obtain benefits (other-benefiting lying) and its relation to theory of mind (ToM) and empathy among 3-5-year-old preschool children. One hundred nine children were recruited from preschools in China. A modified hide-and-seek paradigm was used to measure children's other-benefiting lying behavior, a ToM scale was used to measure children's ToM abilities, and an empathy scale was used to measure children's empathy abilities.

Does deception involve more cognitive control than truth-telling? Meta-analyses of N2 and MFN ERP studies.

A number of psychological theories propose that deception involves more cognitive control than truth-telling. Over the last decades, event-related potentials (ERPs) have been used to unravel this question, but the findings are mixed. To address this controversy, two meta-analyses were conducted to quantify the results of existing studies reporting N2 or medial frontal negativity (MFN) associated with deception.

An experimental investigation of association between children's lying and behavior problems.

Children's lying is a major concern for parents and teachers alike, not only because lying is an antisocial behavior but also because children's lying correlates with other behavior problems, such as aggression and delinquency. Despite considerable correlational evidence demonstrating the relation between children's lying and behavior problems, experimental evidence is scarce. This study uses a novel task to experimentally examine the relation between lying for personal reward and behavior problem symptoms among 9- to 11-year-old typically developed children ( = 275, 139 boys).

The relation between aggression and theory of mind in children: A meta-analysis.

Previous findings on the association between theory of mind (ToM) and aggression in children are mixed. The social skills deficit view regarded ToM as a single-edged sword and proposed that a lack of ToM can lead to aggression, while the double-edged sword view proposed that children with advanced ToM can still show much aggression because children can also leverage ToM to harm others. To resolve the dispute between the two views, we conducted a meta-analysis combining cross-sectional and longitudinal findings from 53 studies including a total of 11,579 children aged between 2 and 15 years.

The developmental origins of a default moral response: A shift from honesty to dishonesty.

People are sometimes tempted to lie for their own benefit if it would not harm others. For adults, dishonesty is the default response in these circumstances. The developmental origins of this phenomenon were investigated between 2019 and 2021 among 6- to 11-year-old Han Chinese children from China (N = 548, 49% female).

A Longitudinal Study of the Relations Between Theory of Mind, Executive Function, and Lying in Children.

This study used longitudinal cross-lagged modeling to examine the contribution of theory of mind (ToM), executive function (EF) to children's lying development and of children's lying to ToM and EF development. Ninety-seven Chinese children (initial  = 46 months, 47 boys) were tested three times approximately 4 months apart. Results showed that the diverse desire understanding and knowledge access understanding components of ToM, as well as the inhibitory control component of EF predicted the development of children's lying, while the diverse belief understanding and false belief understanding components of ToM, and the working memory component of EF did not predict development of children's lying.

Theory of mind, executive function, and lying in children: a meta-analysis.

Scientific research on how children learn to tell lies has existed for more than a century. Earlier studies mainly focused on moral, social, and situational factors contributing to the development of lying. Researchers have only begun to explore the cognitive correlations of children's lying in the last two decades.

Influence of Two Single-Nucleotide Polymorphisms of the Oxytocin Receptor Gene (OXTR) on Empathy: the Mediation Role of a Primary Emotion, CARE.

To feel other's pain would elicit empathy. Some theorists hypothesized that observing other's pain may activate the primary emotion of maternal care instinct, which may function as a precursor of empathy. The maternal care instinct and empathy share the same genetic background and neuroendocrine underpinnings.

How Oxytocin Receptor (OXTR) Single Nucleotide Polymorphisms Act on Prosociality: The Mediation Role of Moral Evaluation.

Prosociality is related to numerous positive outcomes, and mechanisms underlying individual differences in prosociality have been widely discussed. Recently, research has found converging evidence on the influence of the oxytocin receptor () gene on prosociality. Meanwhile, moral reasoning, a key precursor for social behavior, has also been associated with variability in gene, thus the relationship between and prosociality is assumed to be mediated by moral evaluation.

Genetic influences on insight problem solving: the role of catechol-O-methyltransferase (COMT) gene polymorphisms.

People may experience an "aha" moment, when suddenly realizing a solution of a puzzling problem. This experience is called insight problem solving. Several findings suggest that catecholamine-related genes may contribute to insight problem solving, among which the catechol-O-methyltransferase (COMT) gene is the most promising candidate.

The arginine vasopressin V1b receptor gene and prosociality: Mediation role of emotional empathy.

The vasopressin V1b receptor (AVPR1B) gene has been shown to be closely associated with bipolar disorder and depression. However, whether it relates to positive social outcomes, such as empathy and prosocial behavior, remains unknown. This study explored the possible role of the AVPR1B gene rs28373064 in empathy and prosociality.

[Epidemic characteristics and viral antibody level among healthy people of Japanese B encephalitis in Henan province in 2010].

Objective: To understand the epidemic characteristics and viral antibody level among healthy people of Japanese B encephalitis (JE) in Henan province in 2010.

Methods: A total of 433 selected JE cases in Henan province in 2010 were analyzed by descriptive epidemiological method. Xinyang and Luoyang were selected as survey sites in 2010.

[Surveillance of healthy people's Japanese encephalitis neutralizing antibody in some areas of Henan Province].

Objective: To analyze the prevalence characteristics and influence factors of Japanese encephalitis (JE) neutralizing antibody in healthy people.

Methods: Xinyang and Luoyang is the two cities in Henan Province. In 2010, healthy people of these two cities were selected by random sampling method to eight age groups: less than one year old, 1 -2 years old, 3 -4, 5 -6, 7 -14, 15 -19, 20 -59,and above 60 years old, their blood specimens were collected in May before JE infection and in November after JE infection, then followed with epidemiological investigation for JE neutralizing antibody by MCPENT.