Synthesis and chromatographic evaluating of the core-shell SiO with tunable shell thickness and application for separation of Traditional Chinese Medicine oligosaccharides.

The development of core-shell materials for achieving more efficient and rapid chromatographic separations has remained a key objective in separation science. In this study, monodisperse SiO particles (2-4 µm in diameter) were utilized to fabricate core-shell spheres through a combined approach involving a modified sol-gel process and a biphasic system. The synthesis employed 1,6-bis(triethoxysilyl) hexane (BTMSH), 1,2-bis(triethoxysilyl) ethane (BTEE) as a bridging agent with cetyltrimethylammonium bromide (CTAB) acting as a co-template.

Gracillin suppresses cancer progression through inducing Merlin/LATS protein-protein interaction and activating Hippo signaling pathway.

Gene therapy, epigenetic therapies, natural compounds targeted therapy, photodynamic therapy, nanoparticles, and precision medicines are becoming available to diagnose and treat cancer. Gracillin, a natural steroidal saponin extracted from herbs, has shown potent efficacy against a range of malignancies. In this study, we investigated the molecular anticancer mechanisms of gracillin.

Tacrolimus population pharmacokinetic model-informed precision dosing in adult liver transplant patients.

We aimed to explore tacrolimus population pharmacokinetic (PPK) characteristics in adult liver transplantation patients and develop individualized dosing software for precision dosing. Data were retrospectively extracted from adult liver transplantation patients receiving tacrolimus at Chinese PLA General Hospital and Beijing Friendship Hospital. The PPK model was established using Phoenix, with the final model developed through forward inclusion-backward elimination.

Unravelling the Oxygen Evolution Mechanism of Lithium-Rich Antifluorite Prelithiation Agent Based on Anionic Oxidation.

Developing sacrificial cathode prelithiation technology to compensate for irreversible lithium loss is crucial for enhancing the energy density of lithium-ion batteries. Antifluorite Li-rich LiFeO (LFO) is a promising prelithiation agent due to its high theoretical capacity (867 mAh g) and superior decomposition dynamic (<4.0 V vs.

The Feasibility of Nurse Employee Assistance Programs in China Among Nurse Administrators: A Qualitative Research.

This study aims to explore the feasibility of Nurse Employee Assistance Programs (NEAPs) in China and identify associated factors influencing NEAPs implementation from nurse administrators' perceptions. A qualitative approach was undertaken with 21 participants recruited from 7 tertiary hospitals in China that were conducting trials with NEAPs. Semi-structured interviews were carried out, recorded, and transcribed.

Prediction of cognitive conversion within the Alzheimer's disease continuum using deep learning.

Background: Early diagnosis and accurate prognosis of cognitive decline in Alzheimer's disease (AD) is important to timely assignment to optimal treatment modes. We aimed to develop a deep learning model to predict cognitive conversion to guide re-assignment decisions to more intensive therapies where needed.

Methods: Longitudinal data including five variable sets, i.

QSAR modeling on aromatase inhibitory activity of 23 triazole fungicides by tritium-water release assay.

The 1,2,4-triazole fungicides are extensively used in agriculture, and their impacts on aquatic organisms by continuous release are increasingly concerned. Aromatase, a rate-limiting enzyme for androgens converting to estrogens, is considered as a potential target for triazole fungicides. To reveal and predict the aromatase inhibition capacity of the existing and future developed triazole fungicides, 23 commonly used 1,2,4-triazole fungicides were used for the evaluation of their inhibitory effects (expressed as the 50% inhibitory concentration (IC)) on human aromatase by H-HO release assay in the present study.

IL-33/ST2 axis in diverse diseases: regulatory mechanisms and therapeutic potential.

Interleukin-33 (IL-33) is a nuclear factor and member of the IL-1 cytokine family. IL-33 is mainly expressed by epithelial and endothelial cells and exerts its function through interaction with various immune cells, and binding to its receptor can form the IL-33/Suppression of tumorigenicity 2 (ST2) signaling pathway. While most cytokines are actively synthesized within cells, IL-33 is produced passively in response to tissue damage or cell necrosis, indicating its role as a signaling molecule following cellular infection, stress, or trauma.

Nanoparticle-Reinforced Hydrogel with a Well-Defined Pore Structure for Sustainable Drug Release and Effective Wound Healing.

Impaired chronic wounds are a common complication of diabetes. Inhibited angiogenesis and dysfunctional inflammation render diabetic wound healing a critical challenge. Herein, a sustainable therapeutic composite hydrogel is presented for diabetic wound healing, consisting of a cocktail formulation of anti-inflammatory and local anesthetic nanoparticles incorporated into a composite hydrogel.

Peripheral Electrical Stimulation on Motor Function and Activities of Daily Living After Stroke: A Systematic Review and Network Meta-analysis.

Objective: To compare the effects of different peripheral electrical stimulation protocols and current frequencies for poststroke motor function and activities of daily living.

Data Sources: Seven databases (PubMed, Embase, Cochrane Library, Chinese National Knowledge Infrastructure, VIP Database, Wan-Fang Database, and Chinese Biomedical Database) were searched from inception to August 2024.

Study Selection: Two reviewers independently performed the literature selection.

Chromosome-level genome assembly of Cyperus iria, an aggressive weed of rice.

Cyperus iria is an aggressive weed of rice throughout the world. Until now, the reference genome of C. iria has not been published.

First-principles study of anisotropic planar 2D BCN for sub-5 nm high-performance p-type transistors.

Two-dimensional (2D) materials are considered the potential channel for next-generation transistors. Unfortunately, the development of p-type 2D material transistors lags significantly behind that of n-type, thereby impeding the advancement of complementary logical circuits. In this study, we investigated the electronic properties of 2D BCN and analyzed the transport performance of p-type 2D BCN-6 FETs through first-principles calculations.

Polysomnographic endotypes of successful multilevel upper airway surgery for obstructive sleep apnea.

Study Objectives: Multilevel upper airway surgery is effective for some patients with obstructive sleep apnea (OSA), but prediction the response to surgery remains a challenge. The underlying endotypes of OSA include upper airway collapsibility, muscle compensation, loop gain, and the arousal threshold. This study aimed to explore the effect of surgery on polysomnography (PSG)-derived OSA endotypes and establish a surgical response prediction model.

Extensively drug-resistant Acinetobacter baumannii lung abscess and empyema in a patient with fulminant mycoplasma pneumoniae pneumonia.

Acinetobacter baumannii is a pathogen that typically causes nosocomial infections. Its resistance to multiple antibiotics poses significant challenges for treatment. Fulminant Mycoplasma pneumoniae pneumonia (FMPP) is relatively rare despite Mycoplasma pneumoniae pneumonia is common among children and young adults.

Analysis of WD40 genes in kiwifruit reveals the key role of the light-induced AcTTG1-AcMYB75-AcbHLH2 complex in anthocyanin accumulation.

WD40 superfamily genes are integral to various aspects of plant growth and development. Despite the economic importance and agricultural significance of the kiwifruit (Actinidia chinensis), a comprehensive characterization of the WD40 superfamily in this species remains elusive. In this study, we identified 280 WD40-encoding genes within the kiwifruit genome and systematically analyzed their phylogenetic relationships, gene structures, functional domains, and synteny.

Sophaline B inhibits non-small cell lung cancer by activating NLRP3/caspase-1/GSDMD-dependent pyroptosis and PI3K/AKT/mTOR-mediated autophagy.

Sophaline B (SPB), extracted from the seeds of L., is a natural bioactive compound that effectively exerts antiviral activities against the hepatitis B virus. This is the first study to demonstrate that SPB exerts anti-tumor effects on NSCLC by inducing pyroptosis and autophagy.

Transcriptomic Insights into Higher Anthocyanin Accumulation in 'Summer Black' Table Grapes in Winter Crop Under Double-Cropping Viticulture System.

Anthocyanins are responsible for grape ( L.) skin color. To obtain a more detailed understanding of the anthocyanin regulatory networks across' the summer and winter seasons in grapes under a double-cropping viticulture system, the transcriptomes of 'Summer Black' grapes were analyzed using RNA sequencing.

Hsa_circ_0109623 regulates the progression of autoimmune liver disease through Hsa_miR_146b-3p/Sortilin 1-mediated activation of CD4+ T cells.

Background: Autoimmune hepatitis (AIH) is a chronic liver disease characterized by immune-mediated liver inflammation. Despite its global prevalence, the pathogenesis of AIH remains poorly understood, and there is a lack of specific biomarkers and targeted treatments. This study aimed to investigate the role of hsa_circ_0109623, hsa-miR-146b-3p, and Sortilin 1 (SORT1) in AIH and their potential as therapeutic targets.

Evaluation of the Impact of HIFU on Peptide Bond Formation: A Study Using SPE-LC-MS/MS Methodology.

High-intensity focused ultrasound (HIFU) is a noninvasive soft tissue ablation technique, which utilizes ultrasound energy to induce thermal coagulation necrosis in targeted tissues. Whether this high energy causes side effects in vivo, such as the formation of peptide bonds, has not been fully investigated. Glycylglycine is the simplest dipeptide and hence is often used as a model compound for peptide studies.

Filicinic Acid-Based Meroterpenoids with Antiproliferative Activity against Prostate Cancer PC-3 Cells from .

Nine new structurally diverse filicinic acid-based meroterpenoids (-) with four kinds of carbon skeletons were isolated from the rhizomes of . Their structures, including the absolute configurations, were elucidated by comprehensive analysis of spectroscopic data, quantum chemical calculations, and single-crystal X-ray diffraction. Structurally, compounds - feature an unprecedented 6/6/5/6/6/6 hexacyclic system with a rare oxaspiro[4.

[Widely targeted metabolomics reveals differences of secondary metabolites in rhizomes of different Coptis species].

To deeply understand the chemical components and functional differences of the rhizomes from different Coptis species, this study employed widely targeted metabolomics for the metabolic profiling of C. chinensis, C. deltoidea, and C.

β-MnO nanozyme/Ni mediated formation of TriOPD-Ni polymers for specific and background-free detection of carbaryl.

A novel photothermal sensing platform for direct, specific, and background-free detection of carbaryl has been fabricated. Firstly, β-MnO with excellent oxidase-like property has been screened out from MnO with different crystalline structures. Interestingly, Ni as a chelator with nitrogen atom can modulate the MnO catalytic oxidation and assembly of o-phenylenediamine (OPD) to photothermal probe, OPD trimer (triOPD)-Ni polymers, with an excellent photothermal conversion efficiency of 42.

LRRK2 mutation contributes to decreased free water in the nucleus basalis of Meynert in manifest and premanifest Parkinson's disease.

Background: Free-water imaging can predict and monitor dopamine system degeneration in patients with Parkinson's disease (PD). However, brain cholinergic function has not been investigated to date in LRRK2 mutation carriers with or without PD using free-water imaging.

Objectives: To investigate the effect of LRRK2 mutations on the cholinergic system in manifest and premanifest stages of PD using free-water imaging.

Engineered Mesenchymal Stem Cell-Derived Extracellular Vesicles Scavenge Self-Antigens for Psoriasis Therapy via Modulating Metabolic and Immunological Disorders.

Psoriasis is a chronic inflammatory dermatosis driven by excessive activation of the immune system. Recent studies have demonstrated the therapeutic potential of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) to psoriasis because of their immunomodulation functions. Yet, the outcome of MSC-EVs alone is still unsatisfactory and the underlying mechanisms are also unclear.

Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment.

Osteosarcoma (OS) is the most prevalent malignant bone tumor in children and adolescents worldwide. Identification of novel therapeutic targets and development of targeted drugs are one of the most feasible strategies for OS treatment. Ferroptosis, a recently discovered mode of programmed cell death, has been implicated as a potential strategy for cancer therapy.