Multimodal discovery of bavachinin A: A natural FLT3 agonist for treating thrombocytopenia.

Background: Radiation-induced thrombocytopenia (RIT) poses a serious risk to patients with cancer undergoing radiotherapy and leads to hemorrhage and mortality. Unfortunately, effective treatment options for RIT are currently limited.

Purpose: This study aimed to discover active compound from Fructus Psoraleae, a traditional Chinese medicine recognized for its hemostatic properties, and to elucidate its mechanism of action in the treatment of RIT.

Social isolation and risk of mortality in middle-aged and older adults with arthritis: a prospective cohort study of four cohorts.

Social isolation is common and associated with many adverse outcomes. The evidence regarding social isolation and mortality among middle-aged and older adults with arthritis was lacking. The study aimed to examine the association between social isolation and mortality in this population.

Vibration Analysis of Al-AlO Micro-Cantilever Sandwich Beams with Porosity in Fluids.

The vibration of porous Al-AlO micro-cantilever sandwich beams in fluids was studied utilizing the modified couple stress theory and the scale distribution theory (MCST and SDT). Four types of porosity distributions were defined; the uniform distribution of pores was defined as U-type, while O-type, V-type and X-type represented non-uniform distributions of pores. The material properties of different porous sandwich beams were calculated.

Research Progress on Small Molecule Inhibitors of MDM2-p53 Protein-protein Interaction.

The p53 protein, renowned as the "anti-cancer protein," plays a critical role in regulating the cell cycle, inducing apoptosis, and repairing DNA. Its dysregulation often leads to genomic instability and tumorigenesis. MDM2, a key negative feedback regulator of p53, inhibits both the transcriptional activity and stability of p53, thereby suppressing the anti-cancer effect of p53.

Improvement of physicochemical characteristics, bioactivity, flavor and metabolic profiles of mango juice fermented by Limosilactobacillus reuteri.

The aim of this study was to explore the alterations in physicochemical characteristics, bioactivity, flavor and metabolic profiles of mango juice fermented by Limosilactobacillus reuteri FJG2526 (L. reuteri FJG2526). The results exhibited that L.

Comprehensive analysis of scRNA-seq and bulk RNA-seq reveals the non-cardiomyocytes heterogeneity and novel cell populations in dilated cardiomyopathy.

Background: Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure. Infiltration and alterations in non-cardiomyocytes of the human heart involve crucially in the occurrence of DCM and associated immunotherapeutic approaches.

Methods: We constructed a single-cell transcriptional atlas of DCM and normal patients.

Vascular Organoid Generation from Human-Induced Pluripotent Stem Cells.

Vascular organoids derived from human induced pluripotent stem cells (hiPSCs) recapitulate the cell type diversity and complex architecture of human vascular networks. This three-dimensional (3D) model holds substantial potential for vascular pathology modeling and in vitro drug screening. Despite recent advances, a key technical challenge remains in reproducibly generating organoids with consistent quality, which is crucial for downstream assays and applications.

A novel therapeutic strategy for leukopenia: Miltefosine activates the Ras/MEK/ERK pathway to promote neutrophil differentiation.

Leukopenia, marked by diminished white blood cell (WBC) counts, presents significant challenges in the management of hematological malignancies and immunocompromised patients. This study evaluated the therapeutic potential of miltefosine (MFS), a phospholipid analogue, for treating leukopenia. In vitro studies using HL60 and NB4 cells revealed that MFS effectively promoted neutrophil differentiation and function, evidenced by the upregulation of surface markers CD11b, CD11c, CD14, and CD15, as well as enhanced bactericidal activity assessed through the NBT reduction assay.

Analgesic effect of Dahuang Fuzi Decoction in neuropathic pain through inhibiting TNF-α and PI3K-AKT signaling.

Background: Neuropathic pain (NeP) presents considerable challenges in terms of effective management and significantly impacts the quality of life for affected patients. The current treatment options for NeP are limited, highlighting the need for alternative therapeutic approaches. Dahuang Fuzi Decoction (DF), a formula from traditional Chinese medicine, has shown potential in relieving pain symptoms associated with various types of NeP.

Bright and Efficient CsSnBr Light-Emitting Diodes Enabled by Interfacial Reaction-Assisted Crystallization.

Tin-based perovskites are more environmentally friendly than their lead-based alternatives. Perovskite light-emitting diodes (PeLEDs) using iodide-based tin perovskites have achieved considerable advancements in efficiency. However, PeLEDs using bromide-based tin perovskites have not progressed as rapidly, primarily due to challenges in controlling their crystallization processes.

A Novel G-CN Modified Biogenic Mackinawite Mediated by SRB for Boosting Highly Efficient Adsorption and Catalytic Degradation of Antibiotics in Photo-Fenton Process.

FeS-based nanomaterials are widely used in Fenton-like reaction of antibiotics degradation. However, the problems of poor stability and low reusability limit the catalytic efficiency. Herein, the study ingeniously introduced the g-CN into FeS to synthesize g-CN@biogenic FeS (CN-BF-1) nanocomposite with strong interaction of iron ions and "N-pots" by the mediation of sulfate reducing bacteria (SRB).

Efficient Near-Infrared to Blue Photon Upconversion by Ultrafast Spin Flip and Triplet Energy Transfer at Organic/2D Semiconductor Interface.

Solid state photon upconversion by triplet-triplet annihilation (TTA), particularly near-infrared (NIR)-to-blue upconversion, holds instant promise for enhancing optoelectronic and photochemical applications. Despite extensive studies, NIR-to-blue upconversion has remained particularly challenging and elusive due to inherent multiple energy-downhill processes in TTA upconversion. In this study, using atomically thin two dimensional (2D) monolayer semiconductor as a triplet sensitizer, we demonstrate an efficient and robust solid-state NIR-to-blue photon upconversion system.

Herpes Simplex Virus Type 2 Blocks IFN-β Production through the Viral UL24 N-Terminal Domain-Mediated Inhibition of IRF-3 Phosphorylation.

Herpes simplex virus type 2 (HSV-2) is a sexually transmitted virus, the cause of genital herpes, and its infection can increase the risk of HIV-1 infection. After initial infection, HSV-2 can establish lifelong latency within the nervous system, which is likely associated with the virus-mediated immune evasion. In this study, we found that HSV-2 UL24 significantly inhibited the activation of the IFN-β promoter and the production of IFN-β at both mRNA and protein levels.

CircSSR1 regulates pyroptosis of pulmonary artery smooth muscle cells through parental protein SSR1 mediating endoplasmic reticulum stress.

Introduction: Pyroptosis, inflammatory necrosis of cells, is a programmed cell death involved in the pathological process of diseases. Endoplasmic reticulum stress (ERS), as a protective stress response of cell, decreases the unfold protein concentration to inhibit the unfold protein agglutination. Whereas the relationship between endoplasmic reticulum stress and pyroptosis in pulmonary hypertension (PH) remain unknown.

Design, Synthesis, Anti-TMV Activity, and Structure-Activity Relationships of -pregnane C Steroids and Their Derivatives.

-pregnane C steroids exhibit high antiviral activity against the tobacco mosaic virus (TMV). However, the structural modification of -pregnane C steroids and the structure-activity relationship (SAR) of the modified compounds remain unevaluated. Hence, the present study investigated how variations in the original skeletons of natural -pregnane C steroids affect their antiviral activity.

Mahuang Fuzi Xixin decoction: A potent analgesic for neuropathic pain targeting the NMDAR2B/CaMKIIα/ERK/CREB pathway.

Neuropathic pain (NeP) is a condition charactesized by nervous system injury or dysfunction that affects a significant portion of the population. Current treatments are ineffective, highlighting the need for novel therapeutic approaches. Mahuang Fuzi Xixin decoction (MFXD) has shown promise for treating pain conditions in clinical practice; however, its potential against NeP and the underlying mechanisms remain unclear.

Redox-Neutral Coupling of Allyl Alcohols with Trifluoromethyl Ketones via Synergistic Ni-Ti Bimetallic Catalysis.

A redox-neutral coupling of allyl alcohols with trifluoromethyl ketones has been developed via Ni-Ti bimetallic catalysis. This innovative method allows for the efficient synthesis of various β-tertiary trifluoromethyl alcohol-substituted ketones with yields of up to 98%. The reaction is scalable and compatible with a wide range of substrates, including complex bioactive molecules.

Intratumoral microbiota associates with systemic immune inflammation state in nasopharyngeal carcinoma.

Background: The nasopharynx serves as a crucial niche for the microbiome of the upper respiratory tract. However, the association between the intratumoral microbiota and host systemic inflammation and immune status in nasopharyngeal carcinoma (NPC) remain uncertain.

Methods: We performed 5R 16S rDNA sequencing on NPC tissue samples, followed by diversity analysis, LEfSe differential analysis, and KEGG functional prediction.

Risk factors for in-hospital mortality in recipients of allogeneic hematopoietic stem cell transplantation with acute respiratory distress syndrome: a retrospective study based on the 2023 new definition of acute respiratory distress syndrome.

Introduction: ARDS (acute respiratory distress syndrome) is the most severe form of acute hypoxic respiratory failure. Most studies related to ARDS have excluded patients with hematologic diseases, let alone allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. Numerous patients experiencing severe hypoxic respiratory failure do not meet the Berlin definition due to the limitations of diagnosis and treatment.

CircNAP1L4 regulates pulmonary artery smooth muscle cell proliferation via the NAP1L4-mediated super-enhancer-driven glycolysis gene hexokinase II (HK II) in pulmonary hypertension.

Glycolysis is a major determinant of pulmonary artery smooth muscle cell (PASMC) proliferation in pulmonary hypertension (PH). Circular RNAs (circRNAs) are powerful regulators of glycolysis in multiple diseases; however, the role of circRNAs in glycolysis in PH has been poorly characterized. The aim of this study was to uncover the regulatory mechanism of a new circRNA, circNAP1L4, in human pulmonary artery smooth muscle cell (HPASMC) proliferation through the host protein NAP1L4 to regulate the super-enhancer-driven glycolysis gene hexokinase II (HK II).