Publications by authors named "Siying Wu"

The threat posed by light pollution to human health is increasing remarkably. As demand for high-efficiency and bright lighting increases, so does the blue light content from artificial sources. Although animal studies suggested blue light induced depression-like behaviors, human evidence remained limited, and the mechanisms by which blue light affects depression remained elusive.

View Article and Find Full Text PDF

Background: Studies on the associations between nutrient supplement, physical exercise, and depression among persons 65 years and older in China are still lacking. We aimed to investigate the association between nutrient supplement and depression and to explore the role of physical exercise in this association.

Methods: A total of 8,427 older Chinese adults from the Chinese Longitudinal Healthy Longevity Survey were included in this study.

View Article and Find Full Text PDF
Article Synopsis
  • Polystyrene nanoplastics (PS-NPs) are harmful substances that accumulate in organisms and cause neurotoxicity, although the specific mechanisms behind this toxicity are not well understood.
  • In a study using nematodes, researchers found that PS-NPs lead to behavioral damage and harm to specific types of neurons, with significant reductions in neurotransmitter levels observed.
  • The study identified that PS-NPs increase reactive oxygen species (ROS) production and decrease the Sod-2 protein, and showed that using the mitochondrial ROS scavenger Mitoquinone can help reduce these toxic effects.
View Article and Find Full Text PDF

Objective: Ceftazidime-avibactam (CZA) is a novel -lactam/-lactamase inhibitor with activity against carbapenem-resistant  (CRKP) that produce  carbapenemase (KPC). In this study, we report the first cases of CZA resistance to develop during treatment of CRKP infections and identify the resistance mechanism.

Methods: APB/EDTA and NG-Test CARBA5 were used to detect the production of carbapenemase, whole-genome sequencing (WGS) and conjugation experiment were used to identify potential resistance mechanisms of CZA-susceptible (HX1032) and -resistant (HX1192)  isolates.

View Article and Find Full Text PDF

Intervertebral disc degeneration (IVDD) is a prevalent chronic spinal condition characterized by the deterioration of the intervertebral discs (IVD), leading to structural damage and associated pain. This degenerative process is closely linked to oxidative stress injury, which plays a pivotal role in its onset and progression. Oxidative stress in IVDD results from the excessive production of reactive oxygen species (ROS) and impaired ROS clearance mechanisms, disrupting the redox balance within the intervertebral disc.

View Article and Find Full Text PDF

There is growing concern about the concept that exposure to environmental chemicals may be contributing to the obesity epidemic. However, there is no consensus on the obesogenic effects of emerging contaminants from a toxicological and environmental perspective. The potential human exposure and experimental evidence for obesogenic effects of emerging contaminants need to be systematically discussed.

View Article and Find Full Text PDF
Article Synopsis
  • * The method demonstrated high sensitivity (97.9%) and specificity (100%) for identifying various carbapenemases, making it reliable within just 4 hours of testing.
  • * Blood-rsCDM is particularly valuable for resource-limited environments as it can effectively distinguish between different types of carbapenem-producing bacteria, though it has limitations with certain strains like OXA-181.
View Article and Find Full Text PDF

Paraquat (PQ), a commonly used herbicide, is a potent environmental neurotoxin associated with Parkinson's disease (PD) and major depressive disorder (MDD). While the involvement of various brain cell types in the etiology of each disorder is well recognized, the specific cell subtypes implicated in the comorbidity of PD and MDD, especially under PQ neurotoxicity, remain poorly understood. In this study, we used single-cell RNA sequencing (scRNA-seq) to analyze brain tissues from mice with PQ-induced PD with MDD.

View Article and Find Full Text PDF

The emerging presence of environmental obesogens, chemicals that disrupt energy balance and contribute to adipogenesis and obesity, has become a major public health challenge. Molecular initiating events (MIEs) describe biological outcomes resulting from chemical interactions with biomolecules. Machine learning models based on MIEs can predict complex toxic end points due to chemical exposure and improve the interpretability of models.

View Article and Find Full Text PDF
Article Synopsis
  • - The study focuses on improving the identification of Nocardia spp., a rare but serious pathogen, using MALDI-TOF mass spectrometry compared to standard molecular methods for accurate diagnosis and timely treatment.
  • - 76 clinical Nocardia isolates were classified into 12 species, with MALDI Biotyper 3.1 achieving 100% genus-level accuracy and an 84.2% species accuracy, while the MBT Compass 4.1 increased species accuracy to 98.7% thanks to an updated database.
  • - The Bruker mass spectrometer effectively identifies Nocardia species with some limitations for Nocardia brasiliensis, but improvements were noted with different database versions, enhancing species identification
View Article and Find Full Text PDF
Article Synopsis
  • Cobalt nanoparticles (CoNPs) from industries and medical devices are linked to neurotoxicity, but a full assessment of their effects on the central nervous system is missing.
  • Research shows CoNPs cause neurodegenerative damage, cognitive issues, and toxic protein buildup by disrupting autophagy processes in brain cells.
  • Long noncoding RNA NR_030777 helps counteract CoNPs-induced neurodegeneration by stabilizing a key transcription factor (TFEB), suggesting a potential therapeutic target for preventing CNS toxicity from CoNPs.
View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to explore the link between the virulence and carbapenem resistance in strains isolated from blood infections, focusing on identifying carbapenem-resistant and hypervirulent strains (CR-HVKP).
  • Researchers analyzed 192 strains from patient blood cultures between 2016 and 2019, with 96 being carbapenem-resistant (CRKP) and 96 carbapenem-sensitive (CSKP), employing various tests to assess drug susceptibility and virulence.
  • Findings showed significant differences in antibiotic resistance, with CRKP strains having fewer virulence genes and only one CR-HVKP strain detected, which exhibited strong biofilm formation and increased resistance to serum compared to CSKP strains.
View Article and Find Full Text PDF

Objective: To study the distribution and drug resistance characteristics of pathogenic bacteria in the elderly population of China by collecting and analyzing the standardized case data on the pathogens of infections in elderly patients, and to facilitate the establishment of a standardized layered surveillance system for pathogenic bacteria in China.

Methods: We collected the case data of elderly patients (≥65 years old) from 62 sentinel hospitals across the country in 2021. Then, we statistically analyzed the data by patient age, their geographical region, the distribution of pathogenic bacteria, and the drug resistance characteristics of main pathogens.

View Article and Find Full Text PDF

Objective: This study aimed to investigate the influence of exposure to ambient fine particulate matter (PM) and its components during pregnancy on the prevalence of preterm birth (PTB). Additionally, we sought to identify the susceptible exposure window. Furthermore, we explored the potential mediating role of blood analysis and a comprehensive metabolic panel in the association between pollutant exposure and PTB incidence.

View Article and Find Full Text PDF
Article Synopsis
  • Unfavorable lipid and glucose levels may contribute significantly to the development of gestational diabetes mellitus (GDM), yet there is a scarcity of prospective studies on this relationship during pregnancy.
  • The study aimed to examine how lipid profiles and ratios change from early to mid-pregnancy and their correlation with GDM risk among pregnant women in Fujian Province, China.
  • Findings revealed that high levels of certain lipids (like triglycerides and LDL-c) and specific lipid ratios in early and mid-pregnancy are positively linked to increased GDM risk, whereas higher HDL-c levels are associated with a lower risk.
View Article and Find Full Text PDF

The utilization of Cobalt (Co) has surged due to it is critical role in renewable energy technologies and other high-tech applications. Concurrently, the potential health risks associated with Co exposure have raised concerns. Previous studies, including our own, have shown that Co can impair learn and memory functions as an epigenetic hazard, even at low concentrations.

View Article and Find Full Text PDF

Lowing blood lipid levels with probiotics has good application prospects. This study aimed to isolate probiotics with hypolipidemic efficacy from homemade na dish and investigate their mechanism of action. experiments were conducted to determine the cholesterol-lowering ability of five isolates, with results showing that N4 exhibited a high cholesterol-lowering rate of 50.

View Article and Find Full Text PDF

The combined cadmium (Cd) and acid rain pollution poses a significant threat to the global ecological environment. Previous studies on the combined adverse effects have predominantly focused on the aboveground plant physiological responses, with limited reports on the microbial response in the rhizosphere soil. This study employed Populus beijingensis seedlings and potting experiments to simulate the impacts of combined mild acid rain (pH=4.

View Article and Find Full Text PDF

Craniectomy is a lifesaving procedure to alleviate dangerously high intracranial pressure by removing a bone flap from the calvarium. However, the osteointegration of reimplanted bone flap with the existing bone tissue is still a clinical challenge. Hyperbaric oxygen (HBO) therapy has shown efficacy in promoting bone repair and could be a promising treatment for accelerating postoperative recovery.

View Article and Find Full Text PDF

Objective: This study aims to investigate the prevalence of familial cerebral cavernous malformations (FCCMs) in first-degree relatives (FDRs) using familial screening, to describe the distribution of initial symptoms, lesion count on cranial MRI and pathogenic gene in patients.

Methods: Patients with multiple CCMs who enrolled from the Treatments and Outcomes of Untreated Cerebral Cavernous Malformations in China database were considered as probands and FDRs were recruited. Cranial MRI was performed to screen the CCMs lesions, and whole-exome sequencing was performed to identify CCM mutations.

View Article and Find Full Text PDF

A reversible two-channel fluorescent nanocomposite with fluorescence resonance energy transfer (FRET) effect was designed for the development, analysis, and characterization of latent fingerprints (LFPs). For the construction of the FRET probe, a core of mesoporous silicas (MSNs) were used to encapsulate the organic dye rhodamine 6G (RhD-6) as an acceptor, while green-emitting monodisperse phenolic resin nanoparticles (PFR NPs) were selected as a donor. The up-conversion material (UC) of NaYF:Yb,Er was synthesized using a simple hydrothermal method, and the MSNs-RhD-6/PFR (PRM) was electrostatically adsorbed onto the UC nanoparticles using a layer-by-layer method to obtain MSNs-RhD-6/PFR-UC (PMU).

View Article and Find Full Text PDF

Parkinson's disease (PD) is a prevalent neurodegenerative disease and approximately one third of patients with PD are estimated to experience depression. Paraquat (PQ) is the most widely used herbicide worldwide and PQ exposure is reported to induce PD with depression. However, the specific brain region and neural networks underlying the etiology of depression in PD, especially in the PQ-induced model, have not yet been elucidated.

View Article and Find Full Text PDF

Bilirubin-induced brain damage is a serious clinical consequence of hyperbilirubinemia, yet the underlying molecular mechanisms remain largely unknown. Ferroptosis, an iron-dependent cell death, is characterized by iron overload and lipid peroxidation. Here, we report a novel regulatory mechanism of demethylase AlkB homolog 5 (ALKBH5) in acyl-coenzyme A synthetase long-chain family member 4 (ACSL4)-mediated ferroptosis in hyperbilirubinemia.

View Article and Find Full Text PDF

This research examines the association between blood pressure variability (BPV) and renal damage in a cohort of 129 primary aldosteronism (PA) patients, employing ambulatory blood pressure monitoring (ABPM) for comparative analysis with individuals diagnosed with essential hypertension (EH). The study reveals that PA patients exhibited significantly elevated levels of cystatin C and urine microalbumin/creatinine ratio (UACR). Additionally, a higher prevalence of non-dipping blood pressure patterns in PA patients suggests an increased risk of circadian blood pressure regulation disturbances.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionqm69vmtd2oue53tj23jhgekns5a4ore7): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once