Publications by authors named "Siying Cui"
Article Synopsis
- - The study investigates the role of the zinc-finger protein ZFP488 in the development and repair of oligodendrocytes, which are cells responsible for myelination in the central nervous system.
- - Researchers created a genetically modified mouse to understand ZFP488's role, finding that its absence led to delayed myelination during development and impaired recovery post-injury.
- - Analysis showed that ZFP488 promotes the expression of genes necessary for myelination, indicating its critical role in regulating the differentiation of oligodendrocytes at various developmental stages.
Oligodendrocyte differentiation and myelination in the central nervous system are controlled and coordinated by a complex gene regulatory network that contains several transcription factors, including Zfp488 and Nkx2.2. Despite the proven role in oligodendrocyte differentiation little is known about the exact mode of Zfp488 and Nkx2.
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- * Researchers performed single-cell profiling of human fetal cerebella to map the different cellular states in MBs, discovering a unique transitional progenitor that connects stem cells to neurons and is common in aggressive MB forms.
- * By analyzing gene regulatory networks, they found that specific factors (HNRNPH1 and SOX11) linked to poor prognosis in group 3 MBs can be targeted to inhibit tumor growth, revealing new potential pathways for treatments.
The novel concept of local climate zones (LCZs) provides a consistent classification framework for studies of the urban thermal environment. However, the development of urban climate science is severely hampered by the lack of high-resolution data to map LCZs. Using Gaofen-6 and Sentinel-1/2 as data sources, this study designed four schemes using convolutional neural network (CNN) and random forest (RF) classifiers, respectively, to demonstrate the potential of high-resolution images in LCZ mapping and evaluate the optimal combination of different data sources and classifiers.
View Article and Find Full Text PDFThe simultaneous quantitative investigation of aerosol ground observation data and particle concentration data is important for a better understanding of the vertical distribution characteristics of air pollution and formulating reasonable air pollution control measures in Chang'an, Xi'an. CE-318 measurements from October 2018 to April 2021 were systematically analyzed to reveal the seasonal and yearly variations in atmospheric aerosols in Chang'an. Then, the relationship between AOD and particle concentration in different seasons and different pollution degrees was explored.
View Article and Find Full Text PDFObjective: DMD/BMD prenatal diagnosis for 931 foetuses.
Background: DMD is the most common fatal X-linked recessive muscular disease. There is no effective clinical treatment method at present.
Background: Duchenne Muscular Dystrophy (DMD) is the most common muscle disease in children, and there are no effective therapies for DMD or Becker Muscular Dystrophy (BMD). Currently, targeted gene therapy treatments have emerged. As a result, genetic diagnosis is the basis of treatment.
View Article and Find Full Text PDF[Genetic testing of chorionic villi from abortuses during early pregnancy].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
June 2019
Objective: To explore the prevalence and characteristics of chromosomal abnormalities in abortuses during early pregnancy with single nucleotide polymorphism microarray (SNP-array).
Methods: For 520 abortuses, copy number variations (CNVs) in chorionic villi were analyzed with SNP-array.
Results: In 510 (98.
Duchenne muscular dystrophy (DMD) is a common X-linked recessive disorder for which there is no present cure. In this paper, we reported the generation of ZZUi008-A, an induced pluripotent stem cell(iPSC) line derived from chorionic villus(CV) cells of a fetus with a deletion mutation in exon 33 of the dystrophin gene (DMD). The cell line was generated using feeder-free and virus-free conditions, and the established cell line retains the original DMD mutation, a normal karyotype, expresses pluripotency markers, able to differentiate into three lineages.
View Article and Find Full Text PDFExploring the cause of early miscarriage with SNP-array analysis and karyotyping.
J Matern Fetal Neonatal Med
January 2019
Objective: The aim of this study is to explore the cause of miscarriage, providing risk assessment to guide the next pregnancy.
Methods: Four hundred eighty-four products-of-conception (POC) samples were analyzed by single nucleotide polymorphism (SNP) array, and peripheral blood samples of couples were collected for karyotyping or fluorescence in situ hybridization (FISH) analysis.
Results: Four hundred sixty-eight of the 484 (96.