Pop-Up Paper-Based Biosensor for a Dual-Mode Lung Cancer ctDNA Assay Based on Novel CoB Nanosheets with Dual-Enzyme Activities and a Portable Smartphone/Barometer for Readout.

Timely monitoring of circulating tumor DNA (ctDNA) in serum is meaningful for personalized diagnosis and treatment for lung cancer. Cheap and efficient point-of-care testing (POCT) has emerged as a promising method, especially in a low-resource setting. Herein, (i) a 3D pop-up paper-based POCT device was designed and manufactured via a cheap method; it was used for saving time and efficiently building a biosensor; (ii) a novel cobalt boride nanosheet (CoB NS) nanozyme with abundant groups was used for POCT dual-mode signal transduction and then a portable smartphone/pressure meter to readout; (iii) a user-friendly smartphone app was fabricated for achieving more convenient POCT.

In-situ oxidative polymerization of dopamine triggered by CuO in acidic condition and application in "turn-off" sensing.

Dopamine (DA) is a key neurotransmitter whose concentration affects various neurological disorders. Unlike previous methods that synthesize non-fluorescent polydopamine (NFL-PDA) under alkaline conditions, this study introduces a novel "turn-off" sensing method for DA using NFL-PDA synthesized through a unique reaction pathway. In our approach, CuO nanodots, created via a simple reduction method, catalyze the formation of hydroxyl radicals (•OH) in acidic conditions, triggering the oxidative polymerization of DA into NFL-PDA.

Advanced neuroprosthetic electrode design optimized by electromagnetic finite element simulation: innovations and applications.

Based on electrophysiological activity, neuroprostheses can effectively monitor and control neural activity. Currently, electrophysiological neuroprostheses are widely utilized in treating neurological disorders, particularly in restoring motor, visual, auditory, and somatosensory functions after nervous system injuries. They also help alleviate inflammation, regulate blood pressure, provide analgesia, and treat conditions such as epilepsy and Alzheimer's disease, offering significant research, economic, and social value.

Axial mechanical properties of welded orthogonal trapezoidal aluminum honeycomb as filler material for nuclear equipment impact limiter.

Lightweight porous structural materials have excellent energy absorption performance, and their application are gradually appeared. This paper takes the shock-absorbing material of nuclear equipment transportation casks as the starting point, and manufactures an orthogonal trapezoidal aluminum honeycomb by welding (WOTAH). The mechanical properties with different cell thicknesses and cell size ratios under different impact loads are studied through experimental and simulation methods, and the deformation process and energy absorption performance of the materials are obtained.

Regulatory Mechanism of Protein Crotonylation and Its Relationship with Cancer.

Crotonylation is a recently discovered protein acyl modification that shares many enzymes with acetylation. However, it possesses a distinct regulatory mechanism and biological function due to its unique crotonyl structure. Since the discovery of crotonylation in 2011, numerous crotonylation sites have been identified in both histones and other proteins.

Development of a novel ternary MOF nanozyme-based smartphone-integrated colorimetric and microfluidic paper-based analytical device for trace glyphosate detection.

Given the significant and potential fatal implications of glyphosate (GLY) residues on human health and the integrity of ecosystems, their presence has garnered substantial global concern and scrutiny. Herein, we introduced a pioneering colorimetric sensing platform, the first of its kind, based on ternary metal-organic frameworks (ZnCo-ZIFs@MIL-101(Fe)). This innovative platform enabled ultra-sensitive, affordable, portable and rapid on-site detection of GLY.

No causal relationship serum lipids on age-related hearing loss based on Mendelian randomized evidence.

Objectives: Presbycusis, or age-related hearing loss (ARHL) has been a common disability disease among the elderly population. It is particularly essential to identify the underlying role of related risk factors for ARHL diagnosis and treatment. Observational studies have shown that cardiovascular disease may be a factor in ARHL.

Outcomes of proprioceptive training on recovery after anterior cruciate ligament reconstruction: A systematic review and meta-analysis.

Objective: The study was designed to explore the effect of proprioceptive training in contrast to conventional training among individuals following anterior cruciate ligament reconstruction (ACLR). It includes joint position sense (JPS), subjective functional outcomes (Cincinnati, Knee injury Osteoarthritis Outcome Score, International Knee Documentation Committee knee form), muscle strength, pain, and kinesthesia.

Methods: PubMed, EMBASE, The Cochrane Library, and Web of Science databases were searched.

A Rechargeable Urea-Assisted Zn-Air Battery With High Energy Efficiency and Fast-Charging Enabled by Engineering High-Energy Interfacial Structures.

Electrochemical urea oxidation reaction (UOR) offers a promising alternative to the oxygen evolution reaction (OER) in clean energy conversion and storage systems. Nickel-based catalysts are regarded as highly promising electrocatalysts for the UOR. However, their effectiveness is significantly hindered by the unavoidable self-oxidation reaction of nickel species during UOR.

HPV-YAP1 oncogenic alliance drives malignant transformation of fallopian tube epithelial cells.

High grade serous ovarian carcinoma (HGSOC) is the most common and aggressive ovarian malignancy. Accumulating evidence indicates that HGSOC may originate from human fallopian tube epithelial cells (FTECs), although the exact pathogen(s) and/or molecular mechanism underlying the malignant transformation of FTECs is unclear. Here we show that human papillomavirus (HPV), which could reach FTECs via retrograde menstruation or sperm-carrying, interacts with the yes-associated protein 1 (YAP1) to drive the malignant transformation of FTECs.

Distribution of microplastics in Lanzhou section of the Yellow River: Characteristics, ecological risk assessment, and factors analysis.

Microplastic (MP) is an emerging pollutant that has attracted attention in the environmental field, and the research of MPs in freshwater systems needs to be strengthened. To characterize the MPs in surface water and sediments of the western urban river network, water and sediment samples were collected. The results showed that the abundance of MPs in the water body of the river network ranged from 7 to 172 n/L, whereas the abundance of MPs in the sediments ranged from 7 to 144 n/kg, and the average abundance in the dry season was significantly higher than that in the rainy season.

Applications of 2D Nanomaterials in Neural Interface.

Neural interfaces are crucial conduits between neural tissues and external devices, enabling the recording and modulation of neural activity. However, with increasing demand, simple neural interfaces are no longer adequate to meet the requirements for precision, functionality, and safety. There are three main challenges in fabricating advanced neural interfaces: sensitivity, heat management, and biocompatibility.

Management of post-radiation carotid blowout syndrome in patients with head and neck cancer: A systematic review.

Background And Purpose: Carotid blowout syndrome (CBS) is a rare but potentially life-threatening complication that can occur in patients with head and neck cancer (HNC), especially with a history of radiotherapy. This study aimed to review and initially compare managements for post-radiation CBS in patients with HNC.

Materials And Methods: A systematic review of published studies was performed.

MRI and single-cell RNA sequence results reveal the influence of anterior talofibular ligament injury on osteochondral lesions of the talus.

Anterior talofibular ligament injuries and osteochondral lesions of the talus present unique challenges to orthopedic surgeons. This study aimed to investigate the relevant relationship between them by analyzing the Magnetic resonance imaging (MRI) results of clinical patients and single-cell RNA sequence (scRNA seq) results of healthy talus cartilage to discuss the risk factors. Data from 164 patients from 2018 to 2023 was retrospectively analyzed.

Ultrasound-Activatable Vaccine for Enhanced Antigen Self- and Cross-Presentation to Overcome Cancer Immunotherapy Resistance.

Insufficient antigen self-presentation of tumor cells and ineffective antigen cross-presentation by dendritic cells (DCs) contribute to diminished immune recognition and activation, which cause resistance to immunotherapies. Herein, we present an ultrasound-activatable vaccine by utilizing a hybrid nanovesicle composed of a thylakoid (TK)/platelet (PLT) membrane and a liposome encapsulating DNA methyltransferase inhibitor zebularine (Zeb) and sonosensitizer hematoporphyrin monomethyl ether (HMME). Upon local exposure to ultrasound, reactive oxygen species (ROS) are generated and induce the sequential release of the payloads.

Customized Music Therapy Combined With the Counseling and Follow-Up System: Stratified Results for Tinnitus Efficacy.

Objective: Chronic subjective tinnitus is a worldwide intractable problem. In our previous studies, customized music therapy combined with a follow-up system can reduce tinnitus perception and improve anxiety/depression. This study aims to explore which characteristics of tinnitus patients are more likely to benefit from our therapy.

A portable smartphone detection of ctDNA using MnB nanozyme and paper-based analytical device.

The development of point-of-care testing (POCT) for circulating tumor DNA (ctDNA) is meaningful for the non-invasive cancers screening and diagnosis, particularly in resource-limited settings. The microfluidic paper-based analytical device (μPAD) provides an ideal platform, its application in ctDNA assays remains underexplored. In this work, a multifunctional μPAD was manufactured, which can enhance the efficiency and reduce the cost of ctDNA sensing.

Role of polyferric sulfate and ferric chloride on anaerobic fermentation of sludge from novel two-stage process for resource recovery.

Polyferric sulfate (PFS) and ferric chloride (FC) were compared for their efficiencies in capturing organic carbon and phosphorus, and their effects on the anaerobic fermentation process of sludge from a pilot-scale two-stage reactor were studied. Both PFS and FC promoted organic carbon and phosphorus capture. Further study revealed that PFS-based sludge with a dosage of 18 mg Fe/L showed a better volatile fatty acids (VFAs) production performance (202.

Tinnitus pitch does not always fall within the frequency range of hearing loss - a cross-sectional study on the mechanism of tinnitus production.

Background: Clinically, we find that tinnitus patients often have hearing loss. According to the most accepted mechanism of tinnitus, that is, the spontaneous discharge and abnormal synchronization of neurons after afferent reduction, tinnitus frequency is closely related to the frequency of hearing loss.

Objective: The purpose of this study was to investigate the correlation of tinnitus pitch with the frequency of hearing loss.

A sensitive sandwich-type electrochemical aptasensing platform based on TiCT/MoS/MWCNT@rGONR composites for simultaneous detection of kanamycin and chloramphenicol in food samples.

A TiCT/MoS/MWCNT@rGONR nanocomposite was prepared for the first time for building a sensitive electrochemical aptasening platform to simultaneously detect kanamycin (Kana) and chloramphenicol (Cap). Owing to their accordion-like structure, rich surface groups, and high charge mobility, TiCT/MoS/MWCNT@rGONR composites provided a spacious covalent immobilization surface and a better electrochemical aptasensing platform. The aptamers of Kana and Cap used in sensors enhance the selectivity.

Anterior Talofibular Ligament Repair in Combination With Anterior Tibiofibular Ligament Distal Fascicle Transfer for The Treatment of Chronic Lateral Ankle Instability: A Finite Element Analysis.

In recent years, anterior tibiofibular ligament-distal fascicle transfers for anterior talofibular ligament augmentation repair have proposed. However, a comprehensive biomechanical study on the anterior tibiofibular ligament-distal fascicle transfer is still lacking. We are established four distinct groups, namely the normal, the anterior talofibular ligament rupture, the anterior talofibular ligament repair, and the anterior talofibular ligament repair + anterior tibiofibular ligament-distal fascicle transfer.

Label-free fluorescent sensor for sensitive detection of ctDNA based on water stabilized CsPbBr nanosheet.

The detection of circulating tumor DNA (ctDNA), as a practical liquid biopsy technique, was of great significance for the study of cancer diagnosis and prognosis. However, reported methods for detection ctDNA still have some limitations, such as tedious process and high cost. In this study, CsPbBr nanosheet (CsPbBr NS) with high water stability was prepared by etching, and its fluorescence intensity could be stably stored for 1 year.

Comparative Evaluation of Metallic and Biodegradable Suture Anchors in Arthroscopic Repair of Anterior Talofibular Ligament Injury: A Short-term Study on Clinical and Functional Outcomes.

BACKGROUND With the development of arthroscopy and suture anchor, the modified Brostrӧm technique has made remarkable progress. However, it is unclear which material is most suitable for treating anterior talofibular ligament injury (ATFL). This study evaluated the short-term efficacy of 2 suture anchors (metal vs biodegradable materials) in arthroscopic ATFL repair.

A label-free fluorescent sensor for rapid and sensitive detection of ctDNA based on fluorescent PDA nanoparticles.

Technological advances in the detection of circulating tumor DNA (ctDNA) have made new options available for diagnosis, classification, biological studies, and treatment selection. However, effective and practical methods for analyzing this emerging class of biomarkers are still lacking. In this work, a fluorescent biosensor was designed for the label-free detection of ctDNA (EGFR 19 del for non-small cell lung cancer, NSCLC).