Publications by authors named "Siyi Tao"

Article Synopsis
  • The ORF9b protein from SARS-CoV and SARS-CoV-2 is important for the virus to evade the immune system, but the specific ways it works are not fully understood.
  • This study shows that ORF9b can be tagged for degradation through a pathway involving ubiquitination and a complex formation with TOM70, HSP90α, and CUL5, where CUL5 helps degrade ORF9b while HSP90α stabilizes it.
  • Treatments that inhibit HSP90, such as GA or 17-AAG, increase the breakdown of ORF9b and reduce SARS-CoV-2 replication, indicating a potential target for new COVID-19 treatments and enhancing understanding of the host-virus
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Humic substances as major components of waste activated sludge are refractory to degrade and have inhibition in traditional anaerobic digestion (AD). This study for the first time investigated the feasibility and mechanism of microbial electrolysis cell assisted anaerobic digestion (MEC-AD) to break the recalcitrance and inhibition of humic substances. The cumulative methane production of AD decreased from 134.

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  • Poor nurse-patient relationships negatively impact patient care outcomes, making it essential to find reliable ways to measure this dynamic.
  • A new Nurse-Patient Relationship Scale (NPRS) was developed and validated with 23 items focused on five key dimensions of the relationship, utilizing feedback from nursing experts and extensive testing with clinical nurses.
  • The NPRS showed high internal consistency and strong construct validity, indicating it is an effective tool for assessing the nurse-patient relationship in a Chinese context.
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Virus-like particle (VLP) vaccine is considered to be the most promising candidate alternative to the traditional inactivated vaccine for foot-and-mouth disease (FMD). To elicit a desired immune response, hollow mesoporous silica nanoparticles (HMSNs) have been synthesized and utilized as a nanocarrier for FMD VLP vaccine delivery. The as-prepared HMSNs displayed a relatively small particle size (∼260 nm), large cavity (∼150 nm), and thin wall (∼55 nm).

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Aim: This study tested the mediating role of the nurse-patient relationship and self-rated health in the effect of emotional labour on turnover intention among nurses in China.

Background: The underlying mechanism behind the effect of emotional labour on turnover intention remains inadequately understood.

Introduction: Nurses with a high level of emotional labour are predisposed to experiencing poor health and tension in their relationships with patients, which may increase turnover intention.

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuously producing new variants, necessitating effective therapeutics. Patients are not only confronted by the immediate symptoms of infection but also by the long-term health issues linked to long COVID-19. Activation of epidermal growth factor receptor (EGFR) signalling during SARS-CoV-2 infection promotes virus propagation, mucus hyperproduction, and pulmonary fibrosis, and suppresses the host's antiviral response.

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As a safe neuromodulation therapy, rTMS is applied to treat a variety of psychiatric and neurological disorders. Additionally, both aripiprazole and sodium valproate are effective in the treatment of rapid cycling bipolar disorder. This case reports a female patient with a 17-year history of bipolar disorder who developed rapid-circulation bipolar disorder 5 years prior to presentation.

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Article Synopsis
  • Three human coronaviruses have emerged over the last two decades—SARS-CoV, MERS-CoV, and SARS-CoV-2—creating significant health and economic challenges that drive research into their characteristics and treatments.
  • MERS-CoV's ORF4b protein can suppress the immune response but is unstable and degraded by the host's ubiquitin proteasome system, specifically regulated by the UBR5 protein.
  • UBR5 diminishes ORF4b’s anti-immunity effects, thereby inhibiting MERS-CoV's ability to evade the immune system, showcasing a new mechanism through which host cells combat this virus.
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  • Emerging evidence indicates that circular RNAs (circRNAs), particularly circMDK, play a significant role in the progression of hepatocellular carcinoma (HCC) and may serve as oncogenic markers.
  • CircMDK, found to be upregulated in HCC, enhances tumor growth and metastasis by sponging specific microRNAs and activating the PI3K/AKT/mTOR signaling pathway.
  • Delivery of circMDK-targeting siRNA using poly (β-amino esters) significantly inhibits HCC tumor progression in various mouse models, suggesting potential for nanotherapeutic applications in cancer treatment.
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Objectives: Patient-centred communication improves patient experiences and patient care outcomes. This study aimed to assess the preference of medical professionals in China towards patient-centred communication under the context of the deteriorating doctor-patient relationship.

Methods: A cross-sectional survey of medical professionals was conducted in January and February 2018 in H City of Heilongjiang province, the northeast of China.

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With the outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), coronaviruses have begun to attract great attention across the world. Of the known human coronaviruses, however, Middle East respiratory syndrome coronavirus (MERS-CoV) is the most lethal. Coronavirus proteins can be divided into three groups: nonstructural proteins, structural proteins, and accessory proteins.

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Objectives: The doctor-patient relationship is usually measured in line with patient needs and demands. This study aimed to develop a scale measuring such a relationship from the perspective of doctors.

Methods: A draft scale was developed and adapted to the hospital context of China based on several existing scales, with an intention to measure how medical doctors view and manage their relationship with patients beyond episodic clinical encounters.

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Article Synopsis
  • In a study of 47 COVID-19 patients compared to 19 healthy controls, researchers found unique microorganisms in the COVID-19 group and significant changes in gut microbiota composition, including decreased butyrate producers and increased probiotic levels.
  • The research identified 15 microbial markers that could help diagnose COVID-19 and noted correlations between certain gut bacteria and clinical features of the disease, suggesting that gut microbiota alterations may impact COVID-19 severity.
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Cyanotoxins are the underlying cause of the threat that globally pervasive Cyanobacteria Harmful algal blooms (CyanoHABs) pose to humans. Major attention has been focused on the cyanobacterial hepatotoxin microcystins (MCs); however, there is a dearth of studies on cyanobacterial neurotoxin anatoxins. In this study, we explored how an anatoxin-producing strain responded to culture with inorganic and organic nitrogen sources in terms of growth and anatoxins production.

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Objectives: Assessing medical students' attitudes toward patient-centred care is essential to bettering medical education. Based on doctor-patient relationships and the medical system in China, it is important to explore the impact of gender differences and other background factors on patient-centred attitudes and to provide references for medical education reform.

Methods: A cross-sectional study was conducted on fourth-year medical undergraduate students from November 2017 to March 2018 in Heilongjiang Province, Northeast China.

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Deoxynivalenol (DON) is a common contaminant of grain worldwide and is often detected in the human diet and animal feed. Selenium is an essential trace element in animals. It has many biological functions.

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