Filtration of a multi-serotype glycoconjugate vaccine drug product through sterilizing grade 0.2/0.22 µm pore size filters.

Glycoconjugate vaccines containing multiple serotypes of a bacterial capsular polysaccharide can provide strong immune protection against pathogenic infections. Sterile filtration is an important component of the fill and finish operations in the preparation of these vaccines, with the capacity of the sterile filter limited by membrane fouling. The objective of this study was to examine the performance of a range of commercial 0.

VCI-Based Analysis on Spatiotemporal Variations of Spring Drought in China.

The analysis of spatiotemporal variations in drought is important for environmental monitoring and agricultural production. In this study, the spring vegetative drought conditions in China were analyzed by using the vegetation condition index (VCI) as an indicator to reveal the drought characteristics in China from 1981-2015. The results suggest that spring vegetative drought (especially moderate drought) occurs frequently in China, and drought conditions have obvious geographical differences and are highly affected by monsoons.