Bioinspired Electrostatic Capture-and-Release System for Precise Microdroplet Manipulation.

The application of physical fields is crucial for droplet generation and manipulation, underpinning technologies like printing, microfluidic biochips, drug delivery, and flexible sensors. Despite advancements, precise micro/nanoscale droplet generation and accurate microfluidic reactions remain challenging. Inspired by the liquid ejection mechanisms in microscopic organisms, an electrostatic manipulator for the precise capture, emission, and transport of microdroplets is proposed.

A wearable triboelectric impedance tomography system for noninvasive and dynamic imaging of biological tissues.

Tissue imaging is usually captured by hospital-based nuclear magnetic resonance. Here, we present a wearable triboelectric impedance tomography (TIT) system for noninvasive imaging of various biological tissues. The imaging mechanism relies on the obtained impedance information from the different soft human tissues.

Triboelectric sensor with ultra-wide linear range based on water-containing elastomer and ion-rich interface.

The incompatibility of the high sensitivity and wide linear range still restricts the further development of active sensors. Here we report a triboelectric pressure sensor based on water-containing triboelectric elastomer with gradient-based microchannels. Tiny amount of liquid is injected into the triboelectric elastomer and the pressure-induced water bridges can modulate the built-in electric field of the sensor, which enhance the signal linearity near the compression limit.

A Triboelectric-Electromagnetic Hybrid Nanogenerator with Magnetic Coupling Assisted Waterproof Encapsulation for Long-Lasting Energy Harvesting.

Ocean energy harvesting based on a triboelectric nanogenerator (TENG) has great application potential, while the encapsulation of triboelectric devices in water poses a critical issue. Herein, a triboelectric-electromagnetic hybrid nanogenerator (TE-HNG) consisting of TENGs and electromagnetic generators (EMGs) is proposed to harvest water flow energy. A magnetic coupling transmission component is applied to replace traditional bearing structures, which can realize the fully enclosed packaging of the TENG devices and achieve long-lasting energy harvesting from water flow.

Acid-Doped Pyridine-Based Polybenzimidazole as a Positive Triboelectric Material with Superior Charge Retention Capability.

The energy conversion efficiency of a triboelectric nanogenerator (TENG) is severely limited by the charge density of triboelectric materials, while drastic and unavoidable charge decay happens during contact due to the insufficient charge retention capacity of positive triboelectric materials. Here, elaborately synthesized acid-ion-doped pyridine-based polybenzimidazole processing with strong charge retention capability is demonstrated to couple with negatively corona-polarized electrets. As illustrated by thermal stimulation and an ion mass spectrometer, the formation of acid-ion chimerism processes high activation energy for stored charges, and the selective anion migration can compensate the escape of polarized charge.

Improved RAkEL's Fault Diagnosis Method for High-Speed Train Traction Transformer.

The traction system is very important to ensure the safe operation of high-speed trains, and the failure of the traction transformer is the most likely fault in the traction system. Fault diagnosis in actual work relies largely on manual experience. This paper proposes an improved RAkEL (Random -Labelsets) algorithm for the fault diagnosis of high-speed train traction transformers.

Applications of graphene-based nanomaterials in drug design: The good, the bad and the ugly.

Introduction: Graphene-based materials (GBMs) have unique physicochemical properties that make them extremely attractive as platforms for the design of new drugs. Indeed, their bidimensional (2D) morphology, high surface area, mechanical and optical properties, associated to different possibilities for functionalization of their surface, provides opportunities for their use as nanomedicines for drug delivery and/or phototherapies.

Areas Covered: This opinion paper provides an overview of the current status of GBMs in drug design, with a focus on their therapeutic applications, potential environmental and health risks, and some controversial results.

In Situ Imaging of Formaldehyde in Live Mice with High Spatiotemporal Resolution Reveals Aldehyde Dehydrogenase-2 as a Potential Target for Alzheimer's Disease Treatment.

Alterations in formaldehyde (FA) homeostasis are associated with the pathology of Alzheimer's disease (AD). In vivo tracking of FA flux is important for understanding the underlying molecular mechanisms, but is challenging due to the lack of sensitive probes favoring a selective, rapid, and reversible response toward FA. In this study, we re-engineered the promiscuous and irreversible phenylhydrazines to make them selective and reversible toward FA by tuning their nucleophilicity.

Conformational restraint as a strategy for navigating towards lysosomes.

Using the conformational restraint strategy, we developed a hydrazonate-derived coumarin into a lysosome targeting probe for imaging native formaldehyde at the subcellular level. Using this probe, we observed the overproduction of formaldehyde in lysosomes when cells were treated with endoplasmic reticulum (ER) stress inducers, suggesting the involvement of formaldehyde in protein misfolding.