Publications by authors named "Siyang Bai"
The role of circulating immune cells in coronary atherosclerosis remains unclear. This study aimed to assess the causal effects of various immune cells on coronary atherosclerosis using Mendelian randomization (MR). Circulating immune cell datasets were obtained from genome-wide association studies, and coronary atherosclerosis datasets were obtained from FinnGen.
View Article and Find Full Text PDFHow do immune cells shape type 1 diabetes? Insights from Mendelian randomization.
Front Endocrinol (Lausanne)
January 2025
Objective: The role of immune cells in type 1 diabetes (T1D) is unclear. The aim of this study was to assess the causal effect of different immune cells on T1D using Mendelian randomization (MR).
Methods: A dataset of immune cell phenotypes (numbered from GCST0001391 to GCST0002121) was obtained from the European Bioinformatics Institute, while a T1D dataset (numbered finngen_R10_T1D) was obtained from FinnGen.
Objective: The relationship between gut microbiome and trimethylamine oxide (TMAO) has not been fully elucidated. We aimed to assess the causal effects of different gut microbes on TMAO using Mendelian randomization (MR).
Methods: Gut microbiome and TMAO datasets were acquired from genome-wide association studies and screened for single nucleotide polymorphisms according to the basic assumptions of MR.
Unequal causality between autoimmune thyroiditis and inflammatory bowel disease: a Mendelian randomization study.
Front Endocrinol (Lausanne)
November 2024
Objective: This study aims to analyze the causal relationship between autoimmune thyroiditis (AIT) and inflammatory bowel disease (IBD) using bidirectional Mendelian randomization (MR).
Methods: Single nucleotide polymorphisms were obtained from FinnGen. Exposure-outcome causality was assessed using inverse variance weighted, MR-Egger, and weighted median.
Effect of post-traumatic stress disorder on type 2 diabetes and the mediated effect of obesity: a Mendelian randomization study.
Front Endocrinol (Lausanne)
September 2024
Objective: Whether the role of post-traumatic stress disorder (PTSD) on type 2 diabetes (T2D) is mediated by obesity or other mediating factors is controversial. This study was designed to assess the impact of PTSD on genetic susceptibility to T2D and mediating factors.
Methods: The datasets for PTSD, T2D, obesity, hypertension, hyperlipidemia, smoking status, and alcohol consumption were obtained from genome-wide association studies.
Auricular pressure as an adjuvant treatment for type 2 diabetes: data mining and meta-analysis.
Front Endocrinol (Lausanne)
September 2024
Article Synopsis
- - This study investigated the effectiveness of auricular pressure therapy combined with conventional treatments for managing type 2 diabetes, analyzing data from various databases until November 2023.
- - The results showed that patients receiving combined treatment had significantly lower levels of fasting blood glucose, postprandial blood glucose, HbA1c, cholesterol, and blood pressure compared to those only on conventional treatment, with no significant increase in adverse events.
- - Key acupoints identified for auricular pressure therapy included AH, TF, AT, CO, and CO, suggesting that this approach could be a valuable addition to diabetes care.
A Mendelian randomization study of the effect of mental disorders on cardiovascular disease.
Front Cardiovasc Med
June 2024
Objective: The effect of mental disorders (MD) on cardiovascular disease (CVD) remains controversial, and this study aims to analyze the causal relationship between eight MD and CVD by Mendelian randomization (MR).
Methods: Single nucleotide polymorphisms of attention-deficit/hyperactivity disorder (ADHD), anorexia nervosa (AN), anxiety disorder (ANX), autism spectrum disorder (ASD), bipolar disorder (BD), depression, obsessive-compulsive disorder (OCD), schizophrenia (SCZ), and CVD were obtained from UK Biobank and FinnGen. Exposure-outcome causality was tested using inverse variance weighted (IVW), MR-Egger, and weighted median.
Article Synopsis
- This study investigates the causal link between hepatitis B virus (HBV) and the risk of type 2 diabetes (T2D) using a method called Mendelian randomization.
- Researchers analyzed genetic data on chronic hepatitis B, liver conditions, and T2D from large databases.
- The findings suggest that chronic hepatitis B may reduce the risk of developing T2D, while liver cirrhosis and fibrosis increase that risk, potentially changing the relationship based on the severity of the liver disease.
Article Synopsis
- - This study aims to explore the causal relationship between vitamin D levels and autoimmune thyroid diseases (AITD) using a method called Mendelian randomization (MR), which analyzes genetic data to draw conclusions.
- - The researchers found that higher levels of serum 25-hydroxyvitamin D were linked to a lower risk of autoimmune thyroiditis (AIT), but not significantly related to autoimmune hyperthyroidism (AIH) or Graves disease (GD).
- - The results indicate that increasing vitamin D levels may help reduce the risk of AIT, suggesting potential benefits of vitamin D supplementation for prevention and treatment of this specific autoimmune condition.