Publications by authors named "Siyan Jin"
Article Synopsis
- The study aimed to identify factors affecting visual acuity in acute retinal necrosis (ARN) patients who were treated without surgery, analyzing clinical data from 2010 to 2023.
- Among 24 patients, the majority were found to have VZV infection, and over half of the eyes showed improvement in vision following antiviral treatment.
- Key factors linked to poor visual outcomes included retinal detachment, certain types of necrotizing retinitis, and a high neutrophil to lymphocyte ratio, indicating that initial viral load and inflammation levels are crucial for prognosis.
Aim: To review and summarize the mechanism hypothesis, influencing factors and possible consequences of macular retinal displacement after idiopathic macular hole (IMH) surgery.
Methods: PubMed and Web of Science database was searched for studies published before April 2023 on "Retinal displacement", "Idiopathic macular holes", and "Macular displacement".
Results: Recently, more academics have begun to focus on retinal displacement following idiopathic macular holes.
Purpose: To investigate whether the clinical characteristics, treatment and prognosis of endogenous infectious endophthalmitis (EIE) have changed over the past 5 years.
Methods: Retrospectively analyze all articles about EIE published in the PubMed, Web of Science, and Embase databases from 2017 to 2021.
Results: A total of 128 patients and 147 eyes (46 left and 60 right) were included in the study.
Article Synopsis
- This study investigated the link between optical coherence tomography (OCT) measurements and three-dimensional visual function (stereopsis) in patients undergoing surgery for unilateral idiopathic epiretinal membrane (IERM).
- Results showed that after surgery, patients experienced significant improvements in visual functions such as stereopsis, visual acuity, and metamorphopsia, with certain OCT parameters changing notably within three months postoperatively.
- Specifically, differences in OCT measurements between the eyes (interocular differences) were found to be important predictors of stereopsis outcomes, emphasizing the role of retinal structure in visual function recovery following the surgery.
Purpose: To describe the choroidal retinal microvascular system in Vogt-Koyanagi-Harada (VKH) subjects and furnish additional proof for the early authentication and treatment of VKH suffers.
Methods: From the beginning to July 2023, a comprehensive search for issued articles on optical coherence tomography angiography (OCTA) among VKH sufferers was implemented in Embase, PubMed, and Web of Science databases. This meta-analysis included 9 eligible studies.
Article Synopsis
- This study analyzed the impact of vitrectomy and internal limiting membrane (ILM) peeling on foveal displacement in 42 eyes with idiopathic macular holes (IMH).
- It measured several preoperative macular hole parameters and found that after surgery, all patients experienced a shift of the fovea towards the optic disc.
- The degree of foveal displacement was significantly related to the preoperative basal diameter of the hole, while other preoperative factors did not correlate with changes in visual acuity or displacement.
Background: It has been reported that the gut microbiome is involved in the pathogenesis of uveitis, but the specific pathogenic microbes and metabolites in different types of uveitis are still unclear.
Methods: Microbiome and metabolites were detected using 16S ribosomal DNA and LC‒MS/MS (liquid chromatography tandem mass spectrometry) in 45 individuals, including 16 patients with Vogt Koyanagi Harada (VKH), 11 patients with acute anterior uveitis (AAU) and 18 healthy controls.
Result: The diversity of intestinal microbes among the VKH, AAU and control groups was not significantly different.
Open-globe injury is a common cause of blindness clinically caused by blunt trauma, sharp injury, or shock waves, characterised by rupture of the cornea or sclera and exposure of eye contents to the environment. It causes catastrophic damage to the globe, resulting in severe visual impairment and psychological trauma to the patient. Depending on the structure of the globe, the biomechanics causing ocular rupture can vary, and trauma to different parts of the globe can cause varying degrees of eye injury.
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- Cataract is a common eye disease caused by cloudiness in the lens, but the exact molecular causes are still not well understood, complicating prevention efforts.
- The study focuses on CELF1, an RNA binding protein that influences alternative splicing (AS) of genes connected to lens development and health, comparing AS patterns between control cells and cells overexpressing CELF1.
- The findings reveal that CELF1 overexpression leads to significant changes in AS, particularly favoring repression of exon skipping events, with many regulated genes related to DNA repair and other pathways relevant to lens function and cataract progression.
Article Synopsis
- The study investigates the role of the RNA binding protein CELF1 in cataracts, showing that it significantly alters gene expression in human lens cells.
- Researchers conducted experiments involving overexpression of CELF1 and found it increased the expression of genes related to extracellular matrix processes, particularly matrix metalloproteinases (MMPs).
- The findings suggest CELF1's regulatory influence is indirect, not involving direct binding to the RNA of these target genes, highlighting its complex role in lens development and cataract formation.
A macular hole (MH), particularly an idiopathic macular hole (IMH), is a common cause of central vision loss. Risk factors for nonidiopathic MH include high myopia, cystoid macular edema, inflammation, and trauma. MH is primarily diagnosed using slit-lamp microscopy and optical coherence tomography (OCT).
View Article and Find Full Text PDFBackground: With the continuous improvement of surgical instruments in vitrectomy, the use of a trocar and cannula not only optimizes the incision process but also facilitates insertion and withdrawal of instruments during the procedure. Nevertheless, incision-related complications have also been reported in the literature. However, cannula fractures during 25G+ minimally invasive vitrectomy have rarely been reported.
View Article and Find Full Text PDFMicrophthalmos is a type of developmental disorder ophthalmopathy, which can occur isolated or combined with other ocular malformations and can occur secondary to a systemic syndrome. Nanophthalmos is one of the clinical phenotypes of microphthalmos. Due to the special and complex structure of nanophthalmic eyes, the disorder is often associated with many complications, including high hyperopia, angle-closure glaucoma, and uveal effusion syndrome.
View Article and Find Full Text PDFBackground: System lupus erythematosus (SLE) is a severe multisystem autoimmune disease.
Objective: To describe the clinical and pathological features, treatment, and renal outcome in children under 18 years with lupus nephritis (LN).
Methods: The study was undertaken by a questionnaire completed in 26 Grade 3A hospitals' paediatric renal units in China.