Publications by authors named "Sixuan Xia"
Article Synopsis
- Human cancer cell lines are crucial for research, but they must be authentic to serve as reliable models for studying cancer.
- Authentication tests reveal that MGC-803 cells, thought to be from gastric adenocarcinoma, actually contain genetic material from HeLa cells, including DNA from HPV18.
- The study concludes that MGC-803 is a hybrid cell line formed from a fusion of HeLa and another cell line from a donor of Asian descent, indicating a mix of genetic ancestries.
Continuous cell lines are practical models that are widely used in the study of disease mechanisms and particularly cancers. However, the issue of cell line cross-contamination has existed since the 1960s, despite repeated advocation for cell line authentication by many experts. Furthermore, cell line abuse has been underestimated and underreported.
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