Publications by authors named "Sixu Bao"
USP15-Mediated Deubiquitination of FKBP 5 and Activation of the αIIbβ3 Signaling Pathway Regulate Thrombosis in Mice.
Front Biosci (Landmark Ed)
September 2024
Article Synopsis
- After treating human platelets with thrombin, it was found that higher levels of USP15 and FKBP5 were expressed; manipulating USP15 levels affected FKBP5 stability and function.
- In experiments with mice lacking USP15 in their platelets, it was shown that this knockdown led to longer bleeding times and reduced thrombus formation, highlighting USP15's important role in regulating blood clotting.