Publications by authors named "Siwen Chen"

Article Synopsis
  • - Underwater robots enhance knowledge of marine species and habitats but face challenges like sediment disturbance during seabed operations.
  • - While autonomous underwater vehicles and benthic robots have limitations in delicate ecosystems, the proposed maneuverable underwater vehicle minimizes turbulence and resistance to external factors.
  • - This new vehicle allows high-quality observations within 20 cm of the seabed and features real-time path planning to avoid disturbances, demonstrating effectiveness in various marine environments.
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Aiming at the problem that the error of multi-optical axis alignment is difficult to control in the simulation calibration test, a multi-optical axis dynamic compensation alignment method for the space environment simulation system is proposed. The effect of optical axis disturbance on the signal detection link was analyzed to obtain the alignment accuracy requirements, the optical axis alignment error compensation mechanism was established, the target simulation system with long pupil distance was designed, the alignment error transfer model based on topology structure was constructed, and the test prototype was built. The test results show that the static attitude alignment resolution is better than 3" and the position alignment resolution is better than 11µm.

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  • - Ovarian cancer is highly lethal and treatment often involves surgery and chemotherapy, but postoperative chemotherapy is frequently ineffective and has serious side effects, leading to drug resistance.
  • - There is a pressing need for new drug delivery methods to improve treatment effectiveness, and natural polysaccharide polymers have shown promise in enhancing cancer therapies when used alone or alongside traditional treatments.
  • - This paper reviews the latest developments in using natural polysaccharides like hyaluronic acid, chitosan, alginate, and cellulose in ovarian cancer therapies, highlighting their anti-tumor properties and their potential as effective drug delivery systems.
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  • Polysaccharides are gaining attention for use in multifunctional hydrogels, especially for wound healing, due to their biocompatibility, biodegradability, and structural diversity.
  • Natural polysaccharide hydrogels struggle with weak skin adhesion, leading researchers to adopt mussel-inspired catechol modifications to enhance adhesion and add beneficial properties like antioxidant and antibacterial effects.
  • Recent advancements focus on combining various natural polysaccharides (like chitosan and alginate) with mussel-inspired modifications, improving their effectiveness in wound hemostasis and healing applications.
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Skin trauma is a matter of great concern for public health, emphasizing the importance of reconstructing the microenvironment at the trauma site to facilitate tissue regeneration. Therefore, the investigation of innovative wound dressings has significant research and clinical implications. In this study, we prepared a thermosensitive hydrogel based on a hydrophilic-hydrophobic-hydrophilic triblock polycarbonate polymer (PTP), and created a composite hydrogel, PTPH-AZP, by incorporating amorphous zinc phosphate (AZP) nanoclusters.

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Objective: The aim of this study was to analyze the relationship between the characteristics of the intestinal microbiota and cytokine levels in individuals with different degrees of obstructive sleep apnea-hypopnea syndrome (OSAHS) as well as to investigate intestinal microbiota imbalances in patients with OSAHS and the associated mechanisms.

Methods: Based on their sleep apnea hypopnea index (AHI), a total of 37 adults were assigned to a control group, a mild OSAHS group, or a moderate-to-severe OSAHS group. Fecal samples were collected to characterize the intestinal microbiota using metagenomic next-generation sequencing (mNGS), while blood samples were collected to detect levels of interleukin-17a (IL-17a), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) in each group.

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Background: To systematically evaluate the prevalence of scoliosis in adolescents aged 10-18 years in China, and to provide evidence-based evidence for the early identification, prevention, and management of scoliosis in adolescents.

Methods: We searched 7 databases of CNKI, Wanfang, VIP, PubMed, Web of Science, Embase, and Cochrane Library from January 2000 to June 2024, and included related studies on scoliosis among Chinese adolescents aged 10-18. The quality evaluation criteria of cross-sectional studies recommended by the Agency for Healthcare Research and Quality (AHRQ) were used for literature quality evaluation.

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Article Synopsis
  • The study investigates the bioaccumulation of phthalic acid esters (PAEs) in fish within a mangrove ecosystem, focusing on understanding how these chemicals enter the marine environment through plastic manufacturing.
  • Researchers collected samples of fish and their potential food sources from Dongzhai Harbor, analyzing concentrations of nine PAEs and exploring their dietary habits using stable nitrogen and carbon isotope analysis.
  • Findings showed that the median PAE concentration in fish was moderate, with di-n-butyl phthalate (DBP) and diisononyl ortho-phthalate (DINP) being the most prevalent; demersal fish had higher PAE levels due to their diet, highlighting the importance of habitat and food source in PA
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Background: Ankylosing spondylitis (AS) with radiographic damage is more prevalent in men than in women. IL-17, which is mainly secreted from peripheral blood mononuclear cells (PBMCs), plays an important role in the development of AS. Its expression is different between male and female.

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  • The study introduces a new method for simulating optical targets using a liquid crystal display (LCD) to address limitations in achieving both ultraviolet and visible light simulations in one system.
  • It combines an ultraviolet LED and a xenon lamp in a composite light source model, enhancing ultraviolet energy simulation through mixing and homogenization with an integrating sphere.
  • The research also derives key relationships for LCD performance, leading to the design of a wide-ranging transmission projection system that meets specific simulation requirements for accuracy in angular distance and magnitude.
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Radiotherapy-induced immune activation holds great promise for optimizing cancer treatment efficacy. Here, we describe a clinically used radiosensitizer hafnium oxide (HfO) that was core coated with a MnO shell followed by a glucose oxidase (GOx) doping nanoplatform (HfO@MnO@GOx, HMG) to trigger ferroptosis adjuvant effects by glutathione depletion and reactive oxygen species production. This ferroptosis cascade potentiation further sensitized radiotherapy by enhancing DNA damage in 4T1 breast cancer tumor cells.

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NXPH4 promotes cancer proliferation and invasion. However, its specific role and mechanism in cancer remain unclear. Transcriptome and clinical data for pan-cancer were derived from the TCGA database.

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Objective: To investigate the effect of intermittent parathyroid hormone (iPTH) administration on pathological new bone formation during treatment of ankylosing spondylitis-related osteoporosis.

Methods: Animal models with pathological bone formation caused by hypothetical AS pathogenesis received treatment with iPTH. We determined the effects of iPTH on bone loss and the formation of pathological new bone with micro-computed tomography (micro-CT) and histological examination.

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The unequal aperture off-axis optical integrator design method is proposed to improve the irradiation uniformity of solar simulators and solve the problem of limited uniformity of optical integrator due to aberrations and uneven distribution of incident radiation. Firstly, the unequal aperture off-axis optical integrator structure is designed based on the scalar diffraction theory to analyze the factors affecting the optical homogenization ability of the optical integrator. Then, the relationship between sub-eye lens aperture and arrangement is explored in combination with Lagrange invariance principle and semi-definite programming theory.

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Immunotherapy has emerged as an innovative strategy with the potential to improve outcomes in cancer patients. Recent evidence indicates that radiation-induced DNA damage can activate the cyclic-GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway to enhance the antitumor immune response. Even so, only a small fraction of patients currently benefits from radioimmunotherapy due to the radioresistance and the inadequate activation of the cGAS-STING pathway.

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Fractures are frequent and severe musculoskeletal injuries. This study aimed to investigate the function of tenascin-C (TNC) in regulating chondrogenic during fracture healing and elucidate the underlying molecular mechanisms. A well-established femur fracture model in male C57BL/6J mice was used to transect the middle diaphysis of the femur.

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Submerged plants constitute a vital component of shallow lake ecosystems, where water depth and sediment nitrogen‑phosphorus content are two key factors influencing their growth. This study focuses on Vallisneria natans and investigates the morphological and physiological changes of V. natans under the interaction of three water depth gradients and two different sediment nutrient levels.

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Smart elastomers, which possess self-healing and shape memory capabilities, have immense potential in the field of biomedical applications. Polycarbonates and polyesters have gained widespread interest due to their remarkable biocompatibility over the last century. Nevertheless, the lack of functional versatility in conventional polyesters and polycarbonates means that they fall short of meeting the ever-evolving demands of the future.

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Composite elastomers with elasticity, conductivity, and self-healing properties have gained tremendous interest due to the imperative demands in the fields of stretchable electronics and soft robotics. However, the self-healing performance and the amount of filler are contradictory. Herein, a new conductive self-healing composite elastomer is developed by uniformly dispersing EGaIn droplets and Prussian blue nanoparticles (PBNPs) in a bran-new elastomer which cross-linked the linear polymer that obtained by ring-opening polymerization of trimethylene carbonate and 5-methyl-5-carboxytrimethylene carbonate initiated by polyethylene glycol by aluminum chloride.

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Objective: The aim of the study was to investigate the utility of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), evaluate cognitive deficits in systemic lupus erythematosus (SLE) patients and examine the relationship between cognitive and olfactory functions.

Methods: 55 SLE patients and 50 healthy controls were administered by RBANS including five indexes: immediate memory (IMME), visuospatial/constructional (Vis/Con), language (LANG), attention (ATT), and delayed memory (DEME). Olfactory functions were evaluated by computerized testing including three stages of smell: threshold (THR), identification (ID), and memory (ME) of different odors.

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Estuaries are environmental systems with great resource potential and environmental benefits. This study investigates the role of particulate palladium (Pd) in the Nandu River Estuary in the enrichment of estuarine geochemical processes during spring-neap tides. Particulate Pd was found to show different characteristics during spring-neap tides, with the hydrodynamic condition being one of the key factors causing the difference.

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With the application of plastic products, phthalates now widely occur in various environmental media. A large number of ecological risk assessment experiments have only been carried out on a single medium such as water or sediment. There are few reports of ecological risk assessments based on the phase states of phthalic acid esters (PAEs) such as the free dissolved state and the dissolved organic carbon (DOC) adsorption state.

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