Intratumoral and peritumoral ultrasound-based radiomics for preoperative prediction of HER2-low breast cancer: a multicenter retrospective study.

Objectives: Recent advances in human epidermal growth factor receptor 2 (HER2)-targeted therapies have opened up new therapeutic options for HER2-low cancers. This study aimed to establish an ultrasound-based radiomics model to identify three different HER2 states noninvasively.

Methods: Between May 2018 and December 2023, a total of 1257 invasive breast cancer patients were enrolled from three hospitals.

Effects of different microfracture drilling parameters on bone quality: a finite element analysis.

Background: Microfracture drilling is a surgical technique that involves creating multiple perforations in areas of cartilage defects to recruit stem cells from the bone marrow, thereby promoting cartilage regeneration in the knee joint. Increasing the exposed bone marrow surface area (more holes in the same area) can enhance stem cell outflow. However, when the exposed area is large, it may affect the mechanical strength of the bone at the site of the cartilage defect.

ATLAS-seq: a microfluidic single-cell TCR screen for antigen-reactive TCRs.

Discovering antigen-reactive T cell receptors (TCRs) is central to developing effective engineered T cell immunotherapies. However, the conventional technologies for isolating antigen-reactive TCRs (i.e.

Nicotine-Induced Transient Activation of Monocytes Facilitates Immunosuppressive Macrophage Polarization that Restrains T Helper 17 Cell Expansion.

Macrophages in smoking environment exhibit a distinct immunosuppressive phenotype, but the mechanisms that allow nicotine to "educate" macrophages are incompletely understood. Here, we identified that nicotine transiently activates and subsequently deactivates monocytes, leading to reduced anti-infective capability of macrophages. This deactivation results in a suppression of IL-17-producing cell expansion through decreased IL-1β production.

Reconfigurable unitary transformations of optical beam arrays.

Spatial transformations of light are ubiquitous in optics, with examples ranging from simple imaging with a lens to quantum and classical information processing in waveguide meshes. Multi-plane light converter (MPLC) systems have emerged as a platform that promises completely general spatial transformations, i.e.

A Polymeric Hole Transporter with Dual-Interfacial Interactions Enables 25%-Efficiency Blade-Coated Perovskite Solar Cells.

Self-assembly monolayer (SAM) hole transporters, consisting of anchoring, spacer, and terminal groups, have played a significant role in the development of inverted perovskite solar cells (PSCs). However, the weak interaction between perovskite and hydrophobic terminal group of SAMs limits surface wettability and interface stability. To address this issue, two novel hole transporters (named DBPP and Poly-DBPP) with centrosymmetric biphosphonic acid groups are developed.

Polymeric Charge-Transporting Materials for Inverted Perovskite Solar Cells.

Inverted perovskite solar cells (PSCs) hold exceptional promise as next-generation photovoltaic technology, where both perovskite absorbers and charge-transporting materials (CTMs) play critical roles in cell performance. In recent years, polymeric CTMs have played an important role in developing efficient, stable, and large-area inverted PSCs due to their unique properties of high conductivity, tunable structures, and mechanical flexibility. This review provides a comprehensive overview of polymeric CTMs used in inverted PSCs, encompassing polymeric hole transport materials (HTMs) and electron transport materials (ETMs).

Regulating Intermolecular Interactions and Film Formation Kinetics for Record Efficiency in Difluorobenzothiadizole-Based Organic Solar Cells.

The difluorobenzothiadizole (ffBT) unit is one of the most classic electron-accepting building blocks used to construct D-A copolymers for applications in organic solar cells (OSCs). Historically, ffBT-based polymers have achieved record power conversion efficiencies (PCEs) in fullerene-based OSCs owing to their strong temperature-dependent aggregation (TDA) characteristics. However, their excessive miscibility and rapid aggregation kinetics during film formation have hindered their performance with state-of-the-art non-fullerene acceptors (NFAs).

Cordycepin suppresses steroidogenic acute regulatory protein expression by reducing SP1 in human granulosa-lutein cells.

In Brief: Cordycepin (COR), a compound derived from Cordyceps, is recognized as an adenosine analog with numerous beneficial effects on human health. However, its impact on steroidogenic acute regulatory protein (STAR) expression in ovarian granulosa cells is not well understood. This study demonstrates that COR downregulates STAR expression by reducing the expression of the SP1 transcription factor.

DFT Study on the Janus ZrSSe Monolayer for Its Potential Application in NO Gas Sensing.

The growth of industry has resulted in increased global air pollution, necessitating the urgent development of highly sensitive gas detectors. In this work, the adsorption of the Janus ZrSSe monolayer for CO, CO, NH, NO, NO, and O was studied by first-principles calculations. First, the stability of the ZrSSe monolayer is confirmed through calculations of cohesive energy and AIMD simulations.

Efficient and Stable Air-Processed Organic Solar Cells Enabled by an Antioxidant Additive.

Current high-efficiency organic solar cells (OSCs) are generally fabricated in an inert atmosphere that limits their real-world scalable manufacturing, while the efficiencies of air-processed OSCs lag far behind. The impacts of ambient factors on solar cell fabrication remain unclear. In this work, the effects of ambient factors on cell fabrication are systematically investigated, and it is unveiled that the oxidation and doping of organic light absorbers are the dominant reasons causing cell degradation when fabricated in air.

New alkaloids from Stemona tuberosa and structural revision of tuberostemonols P and R.

Three Stemona alkaloids named stemotuberines A-C (1-3) with unique CN frameworks, presumably formed by elimination of the C-11-C-15 lactone ring of the stichoneurine skeleton, were isolated from the roots of Stemona tuberosa. Their structures were elucidated by spectroscopic analysis, X-ray diffraction, and computational methods. Compounds 2 and 3 showed inhibition (IC values of 37.

Intelligent and Bioactive Osseointegration of the Implanted Piezoelectric Bone Cement with the Host Bone Is Realized by Biomechanical Energy.

Poly methyl methacrylate (PMMA) bone cement is widely used in orthopedic surgeries, including total hip/knee arthroplasty and vertebral compression fracture treatment. However, loosening due to bone resorption is a common mid-to-late complication. Therefore, developing bioactive bone cement that promotes bone growth and integration is key to reducing aseptic loosening.

Over 19 % Efficiency Organic Solar Cells Enabled by Manipulating the Intermolecular Interactions through Side Chain Fluorine Functionalization.

Fluorine side chain functionalization of non-fullerene acceptors (NFAs) represents an effective strategy for enhancing the performance of organic solar cells (OSCs). However, a knowledge gap persists regarding the relationship between structural changes induced by fluorine functionalization and the resultant impact on device performance. In this work, varying amounts of fluorine atoms were introduced into the outer side chains of Y-series NFAs to construct two acceptors named BTP-F0 and BTP-F5.

Mo-doping heterojunction: interfacial engineering in an efficient electrocatalyst for superior simulated seawater hydrogen evolution.

Exploring economical, efficient, and stable electrocatalysts for the seawater hydrogen evolution reaction (HER) is highly desirable but is challenging. In this study, a Mo cation doped NiSe/MoSe heterostructural electrocatalyst, Mo-NiSe/MoSe, was successfully prepared by simultaneously doping Mo cations into the NiSe lattice (Mo-NiSe) and growing atomic MoSe nanosheets epitaxially at the edge of the Mo-NiSe. Such an Mo-NiSe/MoSe catalyst requires only 110 mV to drive current densities of 10 mA cm in alkaline simulated seawater, and shows almost no obvious degradation after 80 h at 20 mA cm.

Sonographic and clinicopathologic features of metaplastic breast carcinoma and infiltrating ductal carcinoma: a comparative single-center cohort study.

Background: The rarity of metaplastic breast carcinoma (MBC) has resulted in limited sonographic data. Given the inferior prognosis of MBC compared to invasive ductal carcinoma (IDC), accurate preoperative differentiation between the two is imperative for effective treatment planning and prognostic prediction. The objective of this study was to assess the diagnostic accuracy of MBC and differentiate it from IDC by analyzing sonographic and clinicopathologic features.

Analytic expressions for correlations in coarse-grained simple fluids.

Coarse-graining of fluids is challenging because fluid particles are unbound and diffuse long distances in time. One approach creates coarse-grain variables that group all particles within a region centered on specific points in space and accounts for the movement of particles among such regions. In our previous work, we showed that in many cases, potential interactions for such a scheme adopted a generalized quadratic form, whose parameters depend on means, variances, and correlation coefficients among the coarse-grain variables.

Cu- and Al-Decorated Monolayer TiSe for Enhanced Gas Detection Sensitivity: A DFT Study.

The rapid industrial development has contributed to worsening global pollution, necessitating the urgent development of highly sensitive, cost-effective, and portable gas sensors. In this work, the adsorption of CO, CO, HS, NH, NO, NO, O, and SO gas molecules on pristine and Cu- and Al-decorated monolayer TiSe has been investigated based on first-principles calculations. First, the results of the phonon spectrum and ab initio molecular dynamics simulations demonstrated that TiSe is dynamically stable.

Auxiliary sequential deposition enables 19%-efficiency organic solar cells processed from halogen-free solvents.

High-efficiency organic solar cells are often achieved using toxic halogenated solvents and additives that are constrained in organic solar cells industry. Therefore, it is important to develop materials or processing methods that enabled highly efficient organic solar cells processed by halogen free solvents. In this paper, we report an innovative processing method named auxiliary sequential deposition that enables 19%-efficiency organic solar cells processed by halogen free solvents.

Plasma metabolomic profiling of patients with transient ischemic attack reveals positive role of neutrophils in ischemic tolerance.

Background: Transient ischemic attack (TIA) induces ischemic tolerance that can reduce the subsequent ischemic damage and improve prognosis of patients with stroke. However, the underlying mechanisms remain elusive. Recent advances in plasma metabolomics analysis have made it a powerful tool to investigate human pathophysiological phenotypes and mechanisms of diseases.

Impact analysis of renewable portfolio standard on retail power market considering quota heterogeneity.

To promote the development of the renewable energy (RE) industry, China officially implemented renewable portfolio standard (RPS) in 2020, the policy effect of which is closely related to the amount of renewable power offered to users by power-selling enterprises. We use evolutionary game theory to analyze the behavioral strategies of regional governments, regulatory authorities, and power-selling enterprises under RPS, and build a system dynamics (SD) model to determine the influence of the relevant parameters on stakeholders' strategy making considering quota heterogeneity. The results show that: (1) enterprises evolve to being stable earlier in high-quota area than in low-quota area, which infers that RE development has a certain bottleneck in the initial stage and that RPS can play an effective role; (2) a high certificate price can not only help power selling companies evolve to being stable, but also promote the withdrawal of governments subsidies; (3) to increase the proportion of renewable electricity, the net profit of RE power should not be lower than that of conventional energy; and (4) the incentive effect of subsidy income is not stronger than that of resale income, while when compared with penalty, the incentive effect is stronger, and penalty is not more severe and actually better.

A remote monitoring-enabled home exercise prescription for patients with interstitial lung disease at risk for exercise-induced desaturation.

Rationale: Alternatives to center-based pulmonary rehabilitation are needed to improve patient access to this important therapy. A critical challenge to overcome is how to maximize safety of unsupervised exercise for at-risk patients. We investigated if a novel remote monitoring-enabled mobile health (mHealth) program is safe, feasible, and effective for patients who experience exercise-induced hemoglobin desaturation.

Rational design of a CN/CB p-n heterostructure as a promising anode material in Li-ion batteries.

It is urgent to develop high-performance anode materials for lithium-ion batteries. In this work, a CN/CB p-n heterostructure was systematically investigated by first-principles calculations. The bonding strength of Li in CN is relatively low (-0.

Inversion Symmetry and Exotic Interlayer Exciton Behavior in Twisted Trilayer MoS Produced by Vapor Deposition.

Two-dimensional materials (2DMs) that are stacked vertically with a certain twist angle provide new degrees of freedom for designing novel physical properties. Twist-related properties of homogeneous bilayer and heterogeneous bilayer 2DMs, such as excitons and phonons, have been described in many pioneering works. However, twist-related properties of homogeneous trilayer 2DMs have been rarely reported.

Salicylic Acid Enhances Cadmium Tolerance and Reduces Its Shoot Accumulation in Seedlings by Promoting Root Cadmium Retention and Mitigating Oxidative Stress.

Soil cadmium (Cd) contamination seriously reduces the production and product quality of Tartary buckwheat (), and strategies are urgently needed to mitigate these adverse influences. Herein, we investigated the effect of salicylic acid (SA) on Tartary buckwheat seedlings grown in Cd-contaminated soil in terms of Cd tolerance and accumulation. The results showed that 75-100 µmol L SA treatment enhanced the Cd tolerance of Tartary buckwheat, as reflected by the significant increase in plant height and root and shoot biomass, as well as largely mitigated oxidative stress.