Publications by authors named "Siwar Soussi"
Cyclic lipopeptides produced by Bacillus species exhibit interesting therapeutic potential. However, their clinical use remains limited due to their low stability, undesirable interactions with host macromolecules, and their potential toxicity to mammalian cells. The present work aims to develop suitable lipopeptide-loaded chitosan nanoparticles with improved biological properties and reduced toxicity.
View Article and Find Full Text PDFArticle Synopsis
- Researchers isolated a strain of Bacillus amyloliquefaciens, named C5, from olive tree roots, which produces antibacterial biosurfactant lipopeptides.
- They optimized its antibacterial activity using grape seed flour (GSF) at different concentrations, finding 0.2% GSF yielded the best growth and antimicrobial results, with an MIC of 60 μg/ml.
- Thin layer chromatography and MALDI-TOF/MS analyses indicated the production of multiple lipopeptides, including surfactin and bacillomycin D, highlighting GSF as an effective and affordable medium supplement for biosurfactant production.