FT-ICR-MS combined with fluorescent spectroscopy reveals the driving mechanism of the spatial variation in molecular composition of DOM in 22 plateau lakes.

Dissolved organic matter (DOM) is the largest carbon pool and directly affects the biogeochemistry in lakes. In the current study, fourier transform ion cyclotron mass spectrometry (FT-ICR-MS) combined with fluorescent spectroscopy was used to assess the molecular composition and driving mechanism of DOM in 22 plateau lakes in Mongolia Plateau Lakes Region (MLR), Qinghai Plateau Lakes Region (QLR) and Tibet Plateau Lakes Region (TLR) of China. The limnic dissolved organic carbon (DOC) content ranged from 3.

Molecular characteristics of microalgal extracellular polymeric substances were different among phyla and correlated with the extracellular persistent free radicals.

Extracellular polymeric substance (EPS) plays essential roles in microalgal adaptation to the external environment and aggregate formation. The molecular characteristics of EPS and extracellular persistent free radicals (PFRs) of 15 microalgal species belonging to three phyla were analyzed using Fourier-transform ion cyclotron resonance mass spectrometry (FT-ICR-MS), three-dimensional fluorescence excitation-emission matrices combined with parallel factor analysis (EEM-PARAFAC), and Electron Paramagnetic Resonance Spectrometer (EPR). Lignin accounted for the highest proportion of EPS for Cyanophyta and the proportion of lipids was higher for Bacillariophyta.

Composition of dissolved organic matter (DOM) in wastewater treatment plants influent affects the efficiency of carbon and nitrogen removal.

Wastewater treatment plants (WWTPs) play a critical role in receiving, removing, and discharging dissolved organic matter (DOM) in aquatic systems. To date, understanding the composition and fate of DOM in different WWTPs with various environmental and socioeconomic conditions is limited. This study analyzed DOM components in the influent and effluent samples from 49 WWTPs in China using EEM-PARAFAC and ESI-FT-ICR-MS methods.

Spatial distribution and risk assessment of certain antibiotics in 51 urban wastewater treatment plants in the transition zone between North and South China.

The release of antibiotics from WWTPs into the environment has raised increasing concern worldwide. The monitoring of antibiotics in WWTPs throughout a region is crucial for emerging pollutant management. A large-scale survey of the occurrence, distribution, and ecological risk of seven antibiotics in 51 WWTPs was conducted in Shaanxi Province, China.

Fabrication and characterization of dissolving microneedles for transdermal drug delivery of allopurinol.

Allopurinol (AP) is the first line drug in treating hyperuricemia and gout in clinical by oral drug delivery, which is associated with severe adverse effects and the hepatic first-pass effect. Herein, we first proposed AP encapsulated dissolving microneedles (DMNs) for transdermal drug delivery to realize the sustained drug release and avoid the hepatic first-pass effect, which will help to reduce the adverse effects and improve the bioavailability of AP. DMNs were fabricated by a suspension solution casting method with precisely controlled dose.

Fabrication and Evaluation of Glabridin Tip-loaded Dissolving Microneedles.

Background: The clinical application of glabridin in treating skin diseases has been constrained by the limitations of its poor chemical stability and low skin permeability.

Objective: Here, we describe Tip-loading Dissolving Microneedles (TDMNs) encapsulating drugs only in the tips of needles for glabridin delivery with improved stability and skin permeability.

Methods: The TDMNs fabricated by solvent casting technique had sufficient mechanical strength to penetrate through the excised rat's skin without fracture.

Structure-activity relationships of antityrosinase and antioxidant activities of cinnamic acid and its derivatives.

The related structure-activity relationships of cinnamic acid and its derivates have not been studied in details yet. Herein, antityrosinase and antioxidant activities of 18 compounds were evaluated. The results demonstrated that the substituents on the phenyl ring of cinnamic acid led to the enhancement of the inhibition on monophenolase and the weakening of the inhibition on diphenolase.

Evaluation of antityrosinase activity and mechanism, antioxidation, and UV filter properties of theaflavin.

Tyrosinase is a key metalloenzyme for the biosynthesis of melanin that plays a critical role in the prevention of skin damage caused by ultraviolet (UV) radiation. However, the overproduction of melanin may cause a variety of skin diseases. Due to the toxicity and inefficiency of existing tyrosinase inhibitors, it is urgent to identify safe and potent alternatives from natural sources.