Publications by authors named "Siva Sankara Vara Prasad Sakamuri"
Background & Objectives: Adipose tissue dysfunction in obesity is linked to the development of type 2 diabetes and cardiovascular diseases. We studied the differential gene expression in retroperitoneal adipose tissue of a novel obese rat model, WNIN/Ob, to understand the possible underlying transcriptional changes involved in the development of obesity and associatedcomorbidities in this model.
Methods: Four month old, male WNIN/Ob lean and obese rats were taken, blood was collected and tissues were dissected.
. Increased fructose consumption is linked to the development of metabolic syndrome (MS). Here we investigated the time course of development of MS features in high-fructose-fed Sprague Dawley rats along with circulatory testosterone and homocysteine levels.
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- Atherosclerosis, which leads to heart attacks and strokes, is influenced by inflammation, and TRAF3IP2 might be a key player in plaque formation.
- TRAF3IP2/ApoE double knockout mice showed a decrease in plaque area and necrotic core, along with increased collagen and smooth muscle cell content compared to controls.
- The study found that the absence of TRAF3IP2 reduced inflammatory cytokines and adhesion molecules, indicating it contributes significantly to the development of atherosclerosis.
Background: 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) regulates local glucocorticoid action in tissues by catalysing conversion of inactive glucocorticoids to active glucocorticoids. 11β-HSD1 inhibition ameliorates obesity and associated co-morbidities. Here, we tested the effect of 11β-HSD inhibitor, carbenoxolone (CBX) on obesity and associated comorbidities in obese rats of WNIN/Ob strain, a new animal model for genetic obesity.
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