Publications by authors named "Siu Yin Chan"
Importance: Esophageal squamous cell carcinoma (ESCC) is a deadly disease with frequent recurrence. There are unmet needs for prognostic biomarkers for dynamically monitoring disease progression and detecting minimal residual disease.
Objective: To examine whether circulating tumor DNA is clinically useful as a prognostic biomarker for ESCC recurrence and patient survival.
Background: The standard treatment for locoregionally advanced unresectable esophageal squamous cell carcinoma was radical chemoradiotherapy. However, the prognosis was modest. Emerging evidence showed the concept of induction chemotherapy with a goal of conversion surgery.
View Article and Find Full Text PDFArticle Synopsis
- The study compared the short-term and long-term outcomes of laparoscopic gastrectomy (LG) versus open gastrectomy (OG) for gastric cancer in Hong Kong, analyzing 294 patients from 2008 to 2015.
- Results showed that although LG took longer to perform, it resulted in less blood loss, and there were no significant differences in complications or mortality between the two methods.
- LG demonstrated comparable survival rates and a lower rate of peritoneal recurrences, suggesting it could be increasingly used for gastric cancer treatment, even in advanced cases.
Background: Esophagectomy remains the mainstay treatment for esophageal cancer. Minimally invasive techniques have gained popularity in recent years. Whether minimally invasive methods result in equivalent or superior outcome to open esophagectomy or not is still controversial.
View Article and Find Full Text PDFBackground: Radical surgery is the only curative treatment for carcinoma of gallbladder. This study aimed to evaluate the outcome of patients with carcinoma of gallbladder managed in a single institution over 16 years.
Methods: From April 1988 to November 2003, 86 patients (29 males, 57 females) were diagnosed to have carcinoma of gallbladder.
Surgical resection with a tumor-free margin is the only curative treatment for hilar cholangiocarcinoma (Klatskin tumor). However, over half of the patients present late with unresectable tumors. Radiotherapy using external beam irradiation or intraluminal brachytherapy (ILBT) has been used to treat unresectable hilar cholangiocarcinoma with satisfactory outcome.
View Article and Find Full Text PDF