Publications by authors named "Siu Pui Ying Kelly"
Article Synopsis
- - Mutations in the aquaporin AQP2 lead to resistance against the drugs pentamidine and melarsoprol, with specific amino acid changes influencing drug permeation.
- - The study reveals that TbAQP2 has evolved to allow the passage of pentamidine through its central pore, unlike its counterpart TbAQP3, which requires specific modifications to become permeable.
- - Understanding the structural features that enable pentamidine to pass through TbAQP2 might help improve antitrypanosomal treatments and prevent drug resistance, potentially benefiting the broader aquaporin gene family in pharmacology.
