Quality by Design: Concept to Applications.

Background: Quality by Design (QbD) is associated with a modern, systematic, scientific and novel approach which is concerned with pre-distinct objectives that not only focus on product, process understanding but also lead to process control. It predominantly signifies the design and product improvement and the manufacturing process in order to fulfill the predefined manufactured goods or final products quality characteristics. It is quite essential to identify the desired and required product performance report, such as Target Product Profile, typical Quality Target Product Profile (QTPP) and Critical Quality Attributes (CQA).

Antispasmodic Activity of Aqueous Extract of Flowers of Linn. on Excised Rabbit's Jejunum.

Objective: The present study has been undertaken with the main objective of evaluating the aqueous extract of flowers of for antispasmodic activity on isolated rabbit's jejunum.

Materials And Methods: The study was carried out on isolated rabbit's jejunum preparations. The aqueous extract of flowers of was applied in different doses by cumulative manner without washing the tissue.

Nanoparticles for Cancer Targeting: Current and Future Directions.

The targeting of pharmaceuticals is a rapidly evolving strategy to overcome the difficulties in therapeutic delivery, especially to the tumor site. Unlike traditional drug delivery systems, nanoparticles based compounds attain superior accretion in the tumor site by their active or passive mechanisms. Due to their exclusive properties like small size, large surface-to-volume ratio, tunable surface chemistry, and the ability to encapsulate various drugs, the nano-sized carriers provide longer circulation time; easy penetration into cellular membranes; efficient site-specific targeting.

Liposheres as a Novel Carrier for Lipid Based Drug Delivery: Current and Future Directions.

Researchers are facing challenges to develop robust formulation and to enhance the bioavailability of poorly water-soluble drugs towards clinical applications. The development of new drug molecule alone is not adequate to assure ample pharmacotherapy of various diseases. Considerable results obtained from in vitro studies are not supported by in vivo data due to inadequate plasma drug concentrations.