Single-nucleotide polymorphism of interleukin-10 promoter ( -819C/T) in leprosy patients with and without erythema nodosum leprosum, and healthy household contacts.

Leprosy, caused by is a chronic infectious disease that impacts the skin and peripheral nerves, causing long-term disability. The invasion of into the body triggers immunologic responses and single single-nucleotide polymorphisms in cytokine-encoding genes may influence predisposition and susceptibility, possibly predicting the incidence of leprosy reactions. The aim of this study was to assess the gene polymorphism of interleukin-10 promoter -819C/T in leprosy patients, leprosy patients with erythema nodosum leprosum (ENL) reaction, and household contacts.