Front Med (Lausanne)
November 2024
Background: Septic shock, the most severe stage of sepsis, causes potential circulatory failure and abnormal cell metabolism which are severe enough to affect prognosis, increase mortality, and impose significant burdens on the medical system. Despite a growing number of studies exploring the pathophysiology, epidemiology, and risk factors, research trends and hotspots in septic shock remain lacking. This study aims to create a visual knowledge map, identify research hotspots, and predict prospective trends based on bibliometric analysis.
View Article and Find Full Text PDFThe failure to remyelinate demyelinated axons poses a significant challenge in the treatment of multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system. Here, we investigated the role of Hedgehog (Hh) signaling in myelin formation during development and under pathological conditions. Using conditional gain-of-function analyses, we found that hyperactivation of Hh signaling in oligodendrocyte precursor cells (OPCs) inhibits oligodendrocyte (OL) differentiation and myelination.
View Article and Find Full Text PDFAs a spatial coordinate sensor, the touch-trigger on-machine probe is a key equipment in manufacturing that ensures machining quality, and it has played an important role in five-axis flank milling. However, in flank milling, the utilization of the deviation as a conventional indicator for quality assessment of the machining performance is incomprehensive without considering the characteristics of the machining method. In this paper, the error mutual moment is introduced as an indicator to assess the capability for dynamic machining performance of the machine tool in flank milling based on the spatial coordinate information of the touch-trigger on-machine probe considering the characteristic of the error distribution of the flank milling.
View Article and Find Full Text PDFThe mitigation of methane (CH) emissions from livestock production is crucial to China's carbon neutrality. Here we established a high-spatiotemporal-resolution dataset of the country's livestock CH emissions from 1990 to 2020 using four large-scale national livestock greenhouse gas inventory surveys. We estimate CH emissions to be 14.
View Article and Find Full Text PDFImmunotherapy has emerged as a revolutionizing therapeutic modality for cancer. However, its efficacy has been largely limited by a weak immune response and an immunosuppressive tumor microenvironment. Herein, we report a metal-organic framework (MOF)-derived titanium oxide nanoparticle (MCT NP) as an immune booster that can greatly improve the immunotherapy efficacy by inducing "immunogenic cell death" (ICD) and remodeling the tumor microenvironment.
View Article and Find Full Text PDFObjective: The lung microbiota of patients with pulmonary diseases is disrupted and impacts the immunity. The microbiological and immune landscape of the lungs in patients with pneumocystis pneumonia (PCP) remains poorly understood.
Methods: Multi-omics analysis and machine learning were performed on bronchoalveolar lavage fluid to explore interaction between the lung microbiota and host immunity in PCP.
Background: Self-efficacy, perceived social support, and resilience in caregivers of first-stroke patients are closely related, while the interaction mechanism remains unclear. This research explores the mediation effect of self-efficacy in the relationship between perceived social support and resilience in caregivers of first-stroke patients in China.
Methods: Convenience sampling was designed and used to recruit participants from the General Hospital of Northern Theater in Shenyang, Liaoning Province, China, from February to October 2022, in which 207 self-reported participants completed the Connor-Davidson Resilience Scale (CD-RISC), Multidimensional Scale of Perceived Social Support (MSPSS) and General Self Efficacy Scale (GSES).
Objective: To analyze recurrent factors in patients with clinical early-stage cervical cancer (ESCC) following hysterectomy and adjuvant radiotherapy.
Methods: We collected data from patients with ESCC, staged according to the 2009 Federation International of Gynecology and Obstetrics (FIGO) staging criteria, who underwent hysterectomy followed by adjuvant radiotherapy between 2012 and 2019. These patients were subsequently restaged using the 2018 FIGO criteria.
Halving nitrogen pollution is crucial for achieving Sustainable Development Goals (SDGs). However, how to reduce nitrogen pollution from multiple sources remains challenging. Here we show that reactive nitrogen (Nr) pollution could be roughly halved by managed urban development in China by 2050, with NH, NO and NO atmospheric emissions declining by 44%, 30% and 33%, respectively, and Nr to water bodies by 53%.
View Article and Find Full Text PDFIn order to enhance the separation performance and reduce the heat loss of transmembrane for membrane distillation, the thermal efficiency and hydrophobicity of the membrane distillation need to be simultaneously enhanced. In this work, a polyvinylidene difluoride/polyethylene glycol terephthalate (PVDF/PET) hydrophobic/hydrophilic membrane has been prepared by non-solvent phase induction method. Nanosized silica aerogel (SiAG) with high porosity has been added to the composite membranes.
View Article and Find Full Text PDFEthnopharmacological Relevance: Condyloma acuminatum (CA) is a common sexually transmitted disease. Previous studies using randomized controlled trials (RCTs) have revealed that Paiteling (PTL), a Chinese patent medicine formula, can effectively relieve CA symptoms. However, the evidence needs to be more cohesive and there is a need for a clear summary of the existing RCTs to assess the overall efficacy and safety profile of PTL.
View Article and Find Full Text PDFBackground: Maintaining homeostasis of Ca stores in the endoplasmic reticulum (ER) is crucial for proper Ca signaling and key cellular functions. Although Ca depletion has been known to cause ER stress which in turn activates the unfolded protein response (UPR), how UPR sensors/transducers respond to excess Ca when ER stores are overloaded remain largely unclear.
Results: Here, we report for the first time that overloading of ER Ca can directly sensitize the IRE1α-XBP1 axis.
Objective: To study the effect of ShenKang Injection (SKI) on the kidneys of DKD rats and its effect on oxidative stress mediated by the Keap1/Nrf2/Ho-1 signaling pathway through network pharmacology and in vivo and in vitro experiments.
Methods: SKI drug targets were screened by TCMSP, DKD targets were screened by GenGards, OMIM, Drugbank, TTD, and Disgenet databases, and the two intersected for PPI network analysis and target prediction was performed by GO and KEGG. A total of 40 SD rats were randomly divided into 10 in the control group and 30 in the model group.
A comprehensive analysis of the molecular mechanism underlying colorectal tumor evaluated the development of colorectal cancer (CRC) and proposed targeting small molecular inhibitors. Nonetheless, the adoptive resistance of these therapies remains a challenge with respect to achieving an effective clinical response. Thus, identifying the molecular mechanisms guiding CRC growth is essential.
View Article and Find Full Text PDFMaintaining food production while reducing agricultural nitrogen pollution is a grand challenge under global climate change. Yet, the response of global agricultural nitrogen uses and losses to climate change on the temporal and spatial scales has not been fully characterized. Here, using historical data for 1961-2018 from over 150 countries, we show that global warming leads to small temporal but substantial spatial impacts on cropland nitrogen use and losses.
View Article and Find Full Text PDFis an omnivorous agricultural pest which is great dangerous for grain output. In order to investigate the effects of potential trehalase inhibitors, ZK-PI-5 and ZK-PI-9, on the growth and development of , and to identify new avenues for control, we measured the content of the trehalose, glucose, glycogen and chitin, enzyme activity, and gene expression levels in trehalose and chitin metabolism of . Besides, their growth and development were also observed.
View Article and Find Full Text PDFCropland is a main source of global nitrogen pollution. Mitigating nitrogen pollution from global croplands is a grand challenge because of the nature of non-point-source pollution from millions of farms and the constraints to implementing pollution-reduction measures, such as lack of financial resources and limited nitrogen-management knowledge of farmers. Here we synthesize 1,521 field observations worldwide and identify 11 key measures that can reduce nitrogen losses from croplands to air and water by 30-70%, while increasing crop yield and nitrogen use efficiency (NUE) by 10-30% and 10-80%, respectively.
View Article and Find Full Text PDFTransmembrane of coiled-coil domains 1 (TMCO1) plays an important role in maintaining homeostasis of calcium (Ca) stores in the endoplasmic reticulum (ER). TMCO1-defect syndrome shares multiple features with human cerebro-facio-thoracic (CFT) dysplasia, including abnormal corpus callosum (CC). Here, we report that TMCO1 is required for the normal development of CC through sustaining Ca homeostasis.
View Article and Find Full Text PDFTumours are among the most lethal diseases that heavily endanger human health globally. Xuefu Zhuyu Decoction (XFZYD) is a prescription used to treat blood-activating stasis. Although XFZYD has been shown to suppress migration and invasion of tumour cells, the active ingredients, potential targets, and underlying mechanism remain largely elusive.
View Article and Find Full Text PDFInt J Environ Res Public Health
July 2022
(1) Background: The nurse manager competency model is widely used in hospitals in the management of nursing human resources. This study aimed to construct a scientific and practical model of nurse manager competency, which can be used as a tool by hospitals to select nurse managers. (2) Methods: The nurses' competency indicators were first collected through a literature review and behavioral event interview, and the preliminary screening of competency elements was based on the Delphi method.
View Article and Find Full Text PDFBackground: It is well known that decision aids can promote patients' participation in decision-making, increase patients' decision preparation and reduce decision conflict. The goal of this study is to explore the effects of a "Shared Decision Making Assistant" smartphone application on the decision-making of informed patients with Primary Liver Cancer (PLC) in China.
Methods: In this quasi-experimental study , 180 PLC patients who knew their real diagnoses in the Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China, from April to December 2020 were randomly assigned to a control group and an intervention group.
Background: This study aimed to determine the level of benefit finding among COVID-19 patients in a hospital in mainland China, and to identify its associated impact and public health factors.
Methods: Using a cross-sectional design, a total of 288 COVID-19 patients were recruited in Huoshenshan Hospital in Wuhan, China to complete a survey on benefit finding. The level of benefit finding evaluated by the Benefit Finding Scale (BFS), mental resilience evaluated by the Connor-Davidson Resilience Scale (CD-RISC), social support evaluated by the Multidimensional Scale of Perceived Social Support (MSPSS), medical coping modes evaluated by the Medical Coping Modes Questionnaire (MCMQ), and general information was collected by self-designed questionnaires.
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