Publications by authors named "Sitlali Olguin-Reyes"
Cytochrome P450 2E1 (CYP2E1) has been proposed as a molecular target in oxidative stress-associated metabolic diseases. Rats are chosen as model organisms in most experiments studying CYP2E1-related toxicity; however, the human relevance of these results remains unclear. To describe differences in catalysis and inhibition between human and rat CYP2E1, recombinant human and rat CYP2E1 enzymes were treated with different concentrations of naringenin (NAR, 10 nM - 1 mM), and inhibition parameters were calculated.
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- Hepatocellular cancer, primarily associated with cirrhosis, was studied in an experimental model where time-caloric restriction (limited food access for 2 hours a day) showed promising protective effects against the disease.* -
- The study found that time-caloric restriction reduced liver enlargement, prevented inflammation, and maintained liver function and structure, suggesting it may help maintain a healthier liver environment even in fibrotic areas.* -
- Additionally, the caloric restriction led to changes in circadian rhythm proteins and reduced the progression from liver fibrosis to cirrhosis, implying it may play a significant role in preventing cancer transformation related to liver damage.*
Casiopeína III-Ea (Cas III-Ea(1)) is a copper complex with antiproliferative and antitumor activities, designed to act via alternative mechanisms of action different from Cisplatin. This compound has also been well characterized in preclinical test and pharmacokinetic analysis, being a good candidate for clinical phases. Since very little is known about the processes of biotransformation of therapeutic metal based drugs, this paper report the first approach to the study of the interaction between metal complex Cas III-Ea and cytochromes P450 with the aim to find out possible biotransformation pathways for this complexes and feasible drug-drug interactions.
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